The Mandelin reagent is used as a simple spot-test to presumptively identify
alkaloids
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar st ...
as well as other compounds. It is composed of a mixture of
ammonium metavanadate and concentrated
sulfuric acid
Sulfuric acid (American spelling and the preferred IUPAC name) or sulphuric acid ( Commonwealth spelling), known in antiquity as oil of vitriol, is a mineral acid composed of the elements sulfur, oxygen and hydrogen, with the molecular formu ...
. Its primary use is for the detection of
ketamine
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ne ...
and
PMA Unlike the most common reagent test chemicals, it has a deep red colour that changes to yellow if there is no alkaloid, which occurs within about 48 hours of mixing.
The
United States Department of Justice
The United States Department of Justice (DOJ), also known as the Justice Department, is a federal executive department of the United States government tasked with the enforcement of federal law and administration of justice in the United State ...
method for producing the reagent is the addition of 100 mL of concentrated (95–98%) sulfuric acid to 0.5
-1 g of
Ammonium metavanadate.
This reagent was invented by the German pharmacologist, Karl Friedrich Mandelin (1854–1906) at the
University of Dorpat
The University of Tartu (UT; et, Tartu Ülikool; la, Universitas Tartuensis) is a university in the city of Tartu in Estonia. It is the national university of Estonia. It is the only classical university in the country, and also its biggest ...
.
See also
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Drug checking Drug checking or pill testing is a way to reduce the harm from drug consumption by allowing users to find out the content and purity of substances that they intend to consume. This empowers users to make safer choices: to avoid more dangerous substa ...
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Dille–Koppanyi reagent The Dille–Koppanyi reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.1 g of cobalt(II) acetate dihydrate dissolved in 100 ml of methanol mixed with 0.2 ml of g ...
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Folin's reagent
Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used as a derivatizing agent to measure levels of amines and amino acids. The reagent reacts with them in alkaline solution to produce a fluorescent material that can ...
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Froehde reagent The Froehde reagent is used as a simple spot-test to presumptively identify alkaloids, especially opioids, as well as other compounds. It is composed of a mixture of molybdic acid or a molybdate salt dissolved in hot, concentrated sulfuric acid, wh ...
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Liebermann reagent The Liebermann reagent named after Hungarian chemist Leo Liebermann (1852-1926) is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of potassium nitrite and concentrated sulfuric ...
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Marquis reagent Marquis reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of formaldehyde and concentrated sulfuric acid, which is dripped onto the substance being tested. The United St ...
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Mecke reagent
The Mecke reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of selenous acid and concentrated sulfuric acid, which is dripped onto the substance being tested.
The Unit ...
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Simon's reagent
Simon's reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It reacts with secondary amines like MDMA and methamphetamine to give a blue solution.
Uses
The primary use of this reagent is for dete ...
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Zwikker reagent The Zwikker reagent is used as a simple spot-test to presumptively identify barbiturates. It is composed of a mixture of two solutions. Part A is 0.5 g of copper (II) sulfate in 100 ml of distilled water. Part B consists of 5% pyridine (v/v) in ch ...
References
Chemical tests
Analytical reagents
Drug testing reagents
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