MRK-016 is a selective α
5 subunit-containing
GABAA negative allosteric modulator,
that has
nootropic properties. It has been found to produce rapid,
ketamine
Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ne ...
-like
antidepressant
Antidepressants are a class of medication used to treat major depressive disorder, anxiety disorders, chronic pain conditions, and to help manage addictions. Common side-effects of antidepressants include dry mouth, weight gain, dizziness, hea ...
effects in
animal models of
depression.
See also
*
GABAA receptor negative allosteric modulator
*
GABAA receptor § Ligands
References
Antidepressants
GABAA receptor negative allosteric modulators
Isoxazoles
Nootropics
Triazoles
Tert-butyl compounds
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