Afadin is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''AFDN''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
Afadin is a Ras (see HRAS; MIM 190020) target that regulates cell–cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998).
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Interactions
Afadin has been shown to
interact
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with:
*
BCR gene
The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the ''BCR'' gene. ''BCR'' is one of the two genes in the ''BCR-ABL'' fusion protein, which is associated with the ...
,
*
EPHB3
Ephrin type-B receptor 3 is a protein that in humans is encoded by the ''EPHB3'' gene.
Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their struct ...
,
*
F11 receptor
Junctional adhesion molecule A is a protein that in humans is encoded by the ''F11R'' gene. It has also been designated as CD321 (cluster of differentiation 321).
Function
Tight junctions represent one mode of cell-to-cell adhesion in epithelia ...
,
*
HRAS
GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by the gene. The ''HRAS'' gene is located on the short (p) arm of chromosome 11 at position 15.5, from base pair 522,241 t ...
[ and
* ]LMO2
LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the ''LMO2'' gene.
Function
LMO2 encodes a cysteine- ...
,
* PVRL1
Poliovirus receptor-related 1 (PVRL1), also known as nectin-1 and CD111 (formerly herpesvirus entry mediator C, HVEC) is a human protein of the immunoglobulin superfamily (IgSF), also considered a member of the nectins. It is a membrane protein w ...
,
* PVRL3
Nectin-3, also known as nectin cell adhesion molecule 3, is a protein that in humans is encoded by the ''NECTIN3'' gene.
Nectin-3 belongs to the family of immunoglobulin(Ig)-like cellular adhesion molecules involved in Ca2+-independent cellular ...
,
* Profilin 1
Profilin-1 is a protein that in humans is encoded by the ''PFN1'' gene.
Function
The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in ...
,[
* ]RAP1A
Ras-related protein Rap-1A is a protein that in humans is encoded by the ''RAP1A'' gene.
Function
The product of this gene belongs to the family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the clas ...
,
* RAP1GAP
Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the ''RAP1GAP'' gene.
Interactions
RAP1GAP has been shown to interact with MLLT4
Afadin is a protein that in humans is encoded by the ''AFDN'' gene.
Function
Afad ...
,
* SORBS1
CAP/Ponsin protein, also known as Sorbin and SH3 domain-containing protein 1 is a protein that in humans is encoded by the ''SORBS1'' gene. It is part of a small family of adaptor proteins that regulate cell adhesion, growth factor signaling and ...
,
* SSX2IP,
* Tight junction protein 1
Zonula occludens-1 ZO-1, also known as Tight junction protein-1 is a 220-kD peripheral membrane protein that is encoded by the ''TJP1'' gene in humans. It belongs to the family of ''zonula occludens proteins'' (ZO-1, ZO-2, and ZO-3), which are ti ...
, and
* USP9X.
References
Further reading
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{{PDB Gallery, geneid=4301