Mediator of RNA polymerase II transcription subunit 14 is an
enzyme that in humans is encoded by the ''MED14''
gene.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
Interactions
MED14 has been shown to
interact with
PPARGC1A,
,
STAT2
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the ''STAT2'' gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs). STAT2 se ...
,
,
and
Hepatocyte nuclear factor 4 alpha.
References
Further reading
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