DNA replication licensing factor MCM3 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''MCM3''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the
pre-replication complex
A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of ...
(pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.
Interactions
MCM3 has been shown to
interact
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with:
*
CDC45-related protein,
[
* ]CDC6
Cell division control protein 6 homolog is a protein that in humans is encoded by the ''CDC6'' gene.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. ...
,DBF4
Protein DBF4 homolog A is a protein that is encoded by the ''DBF4'' gene in humans.
Interactions
DBF4 has been shown to interact with:
* Cell division cycle 7-related protein kinase,
* MCM3,
* MCM7,
* ORC2L, and
* ORC6L
Origin recogni ...
,[
* ]MCM2
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the ''MCM2'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the ini ...
[
* ]MCM3AP
80 kDa MCM3-associated protein is a protein that in humans is encoded by the ''MCM3AP'' gene.
Function
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein enco ...
,MCM5
DNA replication licensing factor MCM5 is a protein that in humans is encoded by the ''MCM5'' gene.
Function
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiat ...
,MCM7
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
,ORC4L
Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
,ORC5L
Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
.[
]
See also
*Mini Chromosome Maintenance
The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. As a critical protein for cell division, MCM is also t ...
References
Further reading
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