E3 ubiquitin-protein ligase MARCH2 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''MARCH2''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
It is a member of the MARCH family of E3 ligases, and plays an important role in the
turnover of
membrane proteins
Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane ...
.
MARCH2 has been shown to negatively regulate
NF-κB essential modulator function upon viral and bacterial
infections
An infection is the invasion of tissue (biology), tissues by pathogens, their multiplication, and the reaction of host (biology), host tissues to the infectious agent and the toxins they produce. An infectious disease, also known as a transmiss ...
.
Gene name error in Excel
Like the other MARCH and
septin
Septins are a group of guanosine triphosphate, GTP-molecular binding, binding proteins gene expression, expressed in all eukaryote, eukaryotic cells except plants. Different septins form protein complexes with each other. These complexes can furt ...
genes, care must be exercised when analyzing genetic data containing the MARCH2 gene in
Microsoft Excel
Microsoft Excel is a spreadsheet developed by Microsoft for Microsoft Windows, Windows, macOS, Android (operating system), Android and iOS. It features calculation or computation capabilities, graphing tools, pivot tables, and a macro (comp ...
.
This is due to Excel's autocorrect feature treating the MARCH gene as a date and converting it to a standard date format. The original text cannot be recovered as a result of the conversion. A 2016 study found up to 19.6% of all papers in selected journals to be affected by the gene name error.
The issue can be prevented by using an alias name such as MARCHF2, prepending with an apostrophe ('), or preformatting the cell as text.
References
Further reading
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