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Lymphocystis is a common viral
disease A disease is a particular abnormal condition that negatively affects the structure or function of all or part of an organism, and that is not immediately due to any external injury. Diseases are often known to be medical conditions that a ...
of
freshwater Fresh water or freshwater is any naturally occurring liquid or frozen water containing low concentrations of dissolved salts and other total dissolved solids. Although the term specifically excludes seawater and brackish water, it does include ...
and
saltwater Saline water (more commonly known as salt water) is water that contains a high concentration of dissolved salts (mainly sodium chloride). On the United States Geological Survey (USGS) salinity scale, saline water is saltier than brackish water, ...
fish Fish are aquatic, craniate, gill-bearing animals that lack limbs with digits. Included in this definition are the living hagfish, lampreys, and cartilaginous and bony fish as well as various extinct related groups. Approximately 95% of li ...
. The virus that causes this disease belongs to the genus ''
Lymphocystivirus ''Lymphocystivirus'' is a genus of viruses, in the family ''Iridoviridae''. Fish serve as natural hosts. There are four species in this genus. Diseases associated with this genus include: tumor-like growths on the skin. Hosts ''Lymphocystivirus ...
'' of the family
Iridoviridae ''Iridoviridae'' is a family of viruses with double-stranded DNA genomes. Amphibians, fish, and invertebrates such as arthropods serve as natural hosts. There are currently 22 species in this family, divided among two subfamilies and seven gener ...
.
Aquarist An aquarist is a person who manages aquariums, either professionally or as a hobby. They typically care for aquatic animals, including fish and marine invertebrates. Some may care for aquatic mammals. Aquarists often work at public aquariums. They ...
s often come across this virus when their fish are stressed such as when put into a new environment and the virus is able to grow. The fish start growing small white pin-prick like growths on their
fin A fin is a thin component or appendage attached to a larger body or structure. Fins typically function as foils that produce lift or thrust, or provide the ability to steer or stabilize motion while traveling in water, air, or other fluids. Fin ...
s or skin and this is often mistaken for infection by ''
Ichthyophthirius multifiliis ''Ichthyophthirius multifiliis'', often termed "Ich", is a parasitic ciliate described by the French parasitologist Fouquet in 1876. Only one species is found in the genus which also gave name to the family. The name literally translates as "the ...
'' in the early stages. It soon clumps together to form a cauliflower-like growth on the skin, mouth, fins, and occasionally the
gill A gill () is a respiratory organ that many aquatic organisms use to extract dissolved oxygen from water and to excrete carbon dioxide. The gills of some species, such as hermit crabs, have adapted to allow respiration on land provided they are ...
s. This virus appears to present itself as lesions at differing locations depending on the species of fish being attacked, often complicating initial diagnosis. Lesions at the base of the dorsal fin are common among freshwater species of Central American origin, most notably ''
Herichthys carpintis ''Herichthys carpintis'', the lowland cichlid, pearlscale cichlid, is a species of cichlid. It is endemic to eastern Mexico where it occurs in the Pánuco River drainage, and the Soto La Marina River in northeastern Mexico, its type locality ...
''; inside the mouth of ''
Herichthys cyanoguttatus The Texas cichlid (''Herichthys cyanoguttatus'', formerly ''Cichlasoma cyanoguttatum'') is a freshwater fish of the cichlid family. This is the only cichlid species that is native to the United States. The fish, also known as Rio Grande cichl ...
'' and ''
Geophagus steindachneri The redhump eartheater ('Geophagus steindachneri') is a species of eartheater cichlid from freshwater habitats in northwestern South America.Geophagus steindachneri'. FishBase. Agustin, L., Kullander, S., & Torres, A. (2001-2008). Distribution ...
''; on the tail fin of koi, carp, and US native sunfish (''
Lepomis ''Lepomis'' or true sunfish is a genus of North American freshwater fish from the family Centrarchidae in the order Perciformes (perch-like fish). The generic name ''Lepomis'' derives from the Greek ("scale") and ("cover", "plug", " operculu ...
'' spp.); on the side flanks of walleye, sauger and flounder; on head or tail areas of common goldfish, and oranda variants. Lymphocystis does show some host-specificity, i.e., each strain (or species) of lymphocystis can infect only its primary host fish, or some additional closely related, fish. There is no known cure for this virus, though a privately owned fish research and breeding facility near
Gainesville, Florida Gainesville is the county seat of Alachua County, Florida, Alachua County, Florida, and the largest city in North Central Florida, with a population of 141,085 in 2020. It is the principal city of the Gainesville metropolitan area, Florida, Gaine ...
has reportedly been able to suppress the virus into remission using the human anti-
DNA virus A DNA virus is a virus that has a genome made of deoxyribonucleic acid (DNA) that is replicated by a DNA polymerase. They can be divided between those that have two strands of DNA in their genome, called double-stranded DNA (dsDNA) viruses, and ...
drug
acyclovir Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following tran ...
at the rate of 200 mg per 10 US gallons for 2 days. Otherwise, some aquarists recommend surgery to remove the affected area if it is very serious, followed by an antibiotic bath treatment to prevent a secondary bacterial infection of the open wounds. Eventually the growths inhibit the fish's ability to swim, breathe or eat, and secondary
bacteria Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...
l infections usually kill the fish. Usually the best cure is to simply give the fish a stress-free life, a weekly bacteria treatment and the virus will slowly subside and the fins will repair themselves. This can take many months. Like most viral infections, even in humans, the first outbreaks are the most serious, whilst the immune system "learns" how to suppress it, the outbreaks become less severe over time assuming the organism survives the initial outbreaks.


External links


Histopathology of Marine and Freshwater Fish Lymphocystis (PDF)


Fish viral diseases Fishkeeping {{veterinary-med-stub