Loganic acid is an
iridoid
Iridoids are a type of monoterpenoids in the general form of cyclopentanopyran, found in a wide variety of plants and some animals. They are biosynthetically derived from 8-oxogeranial. Iridoids are typically found in plants as glycosides, mos ...
. Loganic acid is synthesized from
7-deoxyloganic acid
7-Deoxyloganic acid is an iridoid monoterpene. 7-Deoxyloganic acid is produced from 7-deoxyloganetic acid by the enzyme 7-deoxyloganetic acid glucosyltransferase (7-DLGT).Salim, Yu, Altarejos and De Luca (2013) Virus-induced gene silencing iden ...
by the enzyme
7-deoxyloganic acid hydroxylase (7-DLH). It is a substrate for the enzyme
loganate O-methyltransferase
In enzymology, a loganate O-methyltransferase () is an enzyme that catalyzes the chemical reaction
:S-adenosyl-L-methionine + loganic acid \rightleftharpoons S-adenosyl-L-homocysteine + loganin
Thus, the two substrates of this enzyme are S-aden ...
for the production of
loganin
Loganin is one of the best-known of the iridoid glycosides. It is named for the Loganiaceae, having first been isolated from the seeds of a member of that plant family, namely those of ''Strychnos nux-vomica''. It also occurs in ''Alstonia boonei' ...
.
[Dewick (2009) Medicinal Natural Products: A Biosynthetic Approach.]
References
Iridoid glycosides
Glucosides
Carboxylic acids
Cyclopentanes
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