Leslie Clarence Dunn (November 2, 1893 in
Buffalo, New York – March 19, 1974) was a
developmental geneticist
Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction, metamorphosis, and the growth and differentiation of stem ce ...
at
Columbia University. His early work with the mouse
T-locus
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans by the ''TBXT'' gene. Brachyury functions as a transcription factor within the T-box, T-box family of genes. Brachyury Sequence homology, homologs have been f ...
and established ideas of
gene interaction
Epistasis is a phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other words, the effect of the mutation is dep ...
,
fertility factors, and
allelic distribution
An allele (, ; ; modern formation from Greek ἄλλος ''állos'', "other") is a variation of the same sequence of nucleotides at the same place on a long DNA molecule, as described in leading textbooks on genetics and evolution.
::"The chro ...
.
[ American Philosophical Society (2000)]
"L. C. Dunn Biography"
Later work with other
model organism
A model organism (often shortened to model) is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the model organism will provide insight into the workin ...
s continued to contribute to developmental genetics.
Dunn was also an activist, helping fellow scientists seek asylum during World War II, and a critic of
eugenics movements.
[Melinda Gormley]
"Geneticist L.C. Dunn: Politics, Activism, and Community"
(2006 dissertation, Oregon State University).
Biography
Dunn was born in
Buffalo, New York, in 1893, to Clarence Leslie Dunn and Mary Eliza Booth Dunn.
[Theodosius Dobzhansky]
''Leslie Clarence Dunn, 1893-1974: A Biographical Memoir''
(National Academy of Sciences 1978) He earned a bachelor's degree from
Dartmouth College in 1915.
Dunn served in the
Harvard Regiment
The 20th Massachusetts Volunteer Infantry, also known as the "Harvard Regiment," was a regiment of infantry in the American Civil War. The regiment was so nicknamed because the officers of the 20th were young Harvard graduates. In addition, some, ...
in France during
World War I, and after the war, returned to
Harvard University to complete his degree in 1920.
After the war, he identified as a pacifist.
He worked from 1920 to 1928 as a poultry geneticist at the
Storrs Agricultural Experiment Station in
Connecticut, publishing almost fifty papers during this time.
Dunn, along with colleague
E. W. Sinnott
Edmund Ware Sinnott (February 5, 1888–January 6, 1968) was an American botanist and educator. Sinnott is best known for his work in Plant anatomy, plant morphology.
Career
Sinnott received his Bachelor of Arts (1908), Master of Arts (1910), ...
, was the author of one of the foremost early genetics texts, ''Principles of Genetics'' (first published in 1925).
In 1928 Dunn was invited to join
Columbia University as a full professor in the Zoology Department.
While there, he was renowned for his teaching, expanded his work somewhat into ''
Drosophila'' (discovering mutations including ''
Minute
The minute is a unit of time usually equal to (the first sexagesimal fraction) of an hour, or 60 seconds. In the UTC time standard, a minute on rare occasions has 61 seconds, a consequence of leap seconds (there is a provision to insert a nega ...
'' and ''
Bar
Bar or BAR may refer to:
Food and drink
* Bar (establishment), selling alcoholic beverages
* Candy bar
* Chocolate bar
Science and technology
* Bar (river morphology), a deposit of sediment
* Bar (tropical cyclone), a layer of cloud
* Bar (u ...
''),
and influenced numerous students, included "outstanding" developmental biologists
Salome Gluecksohn-Waelsch
Salome Gluecksohn-Waelsch (October 6, 1907 – November 7, 2007) was a German-born U.S. geneticist and co-founder of the field of developmental genetics, which investigates the genetic mechanisms of development.Scott Gilbert"Salome Gluecksohn ...
and
Dorothea Bennett,
and worked with
Ann Chester Chandley
Ann Chester Chandley DSc, F.I.Biol., FRSE (died 19 February 2020) was an international cytogeneticist with the Medical Research Council unit which became the Human Genetics Unit at the University of Edinburgh. She became a Fellow of the Insti ...
.
Dunn was married to Louise Porter, a
Smith College
Smith College is a Private university, private Liberal arts colleges in the United States, liberal arts Women's colleges in the United States, women's college in Northampton, Massachusetts. It was chartered in 1871 by Sophia Smith (Smith College ...
graduate, and the couple had two children, Robert Leslie Dunn (b. 1921) and Stephen Porter Dunn (b. 1928).
Dunn and his family loved literature and poetry, as did Dunn's mother,
and established a press (Coalbin Press) to publish occasional volumes of poetry.
The younger son,
Stephen, was a
social anthropologist and writer, publishing books such as ''The Peasants of Central Russia'' (1967) and ''Introduction to Soviet Ethnography'' (1974) (with his wife Ethel Deikman Dunn), ''Cultural Processes in the Baltic Area Under Soviet Rule'' (1966), and edited, translated, and taught.
He died on March 19, 1974, at
Phelps Memorial Hospital
Phelps Hospital, part of the Northwell Health system, is a general hospital located in Sleepy Hollow, New York
Sleepy Hollow is a village in the town of Mount Pleasant, in Westchester County, New York, United States. The village is located ...
in
North Tarrytown, New York
Sleepy Hollow is a village in the town of Mount Pleasant, in Westchester County, New York, United States. The village is located on the east bank of the Hudson River, about north of New York City, and is served by the Philipse Manor stop on ...
.
Significant papers and contributions
* Dunn, L.C. 1920. "Independent Genes in Mice", ''Genetics'', v.5, pp. 344–361.
* Dunn, L.C. 1920. "Linkage in mice and rats", ''Genetics'', v.5, pp. 325–343. (Dunn's dissertation at Harvard)
* Dunn, L.C. 1957. "Evidence of evolutionary forces leading to the spread of lethal genes in wild populations of house mice", ''Proc. Natl. Acad. Sci. USA'' v.43, pp. 158–163.
* Dunn, L. C. 1959. "Heredity and Evolution in Human Populations", v.75, pp. 117–192.
* Dunn, L.C. 1964. "Abnormalities associated with a chromosome region in the mouse", ''Science'', v.144, pp. 260–263.
* Dunn, L.C. and W.C. Morgan. 1952. "A mutable locus in wild populations of house mice", ''Am. Nat.'' v.86, pp. 321–323.
* Dunn, L.C., H. Gruneberg, and G.D. Snell. 1940. "Report of the Committee on Mouse Genetics Nomenclature", ''J. Hered.'' v.31, pp. 505–506.
* Dunn, L.C. 1951. ''Race and Biology: The Race Question in Modern Science'' (
UNESCO, 1951; 3rd edition 1970)
* ''Heredity, Race, and Society'' (1946; fourth edition 1972)
* ''A Short History of Genetics'' (1965)
* Organizer, with
Milislav Demerec
Milislav Demerec (January 11, 1895 – April 12, 1966) was a Croatian-American geneticist, and the director of the Department of Genetics, Carnegie Institution of Washington IW now Cold Spring Harbor Laboratory (CSHL) from 1941 to 1960, re ...
, The
Cold Spring Harbor Symposia
Cold is the presence of low temperature, especially in the atmosphere. In common usage, cold is often a subjective perception. A lower bound to temperature is absolute zero, defined as 0.00K on the Kelvin scale, an absolute thermodynamic ...
, 1940s-1950s
Awards and honors
*
U.S. National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...
(elected 1943)
*
American Philosophical Society (1943)
*
American Academy of Arts and Sciences (1950)
*
Norwegian Academy of Sciences
*
Italian Academia Pataviana
Italian(s) may refer to:
* Anything of, from, or related to the people of Italy over the centuries
** Italians, an ethnic group or simply a citizen of the Italian Republic or Italian Kingdom
** Italian language, a Romance language
*** Regional ...
* Founding member,
Genetics Society of America
The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the
American Soc ...
* President,
Genetics Society of America
The Genetics Society of America (GSA) is a scholarly membership society of more than 5,500 genetics researchers and educators, established in 1931. The Society was formed from the reorganization of the Joint Genetics Sections of the
American Soc ...
, 1932
* President,
American Society of Naturalists, 1960
* President,
American Society of Human Genetics, 1961
Notes
Further research
*
American Philosophical SocietyL. C. Dunn Biography* William deJong-Lambert, ''The Cold War Politics of Genetic Research: An Introduction to the Lysenko Affair'', Chapter 1, Sections 1.4: "Julian Huxley and Leslie Clarence Dunn" and 1.5 "
J. B. S. Haldane, and Dunn's Visit to the Soviet Union".
*
Theodosius Dobzhansky''Leslie Clarence Dunn, 1893-1974: A Biographical Memoir''(National Academy of Sciences 1978)
* Melinda Gormley
"Geneticist L.C. Dunn: Politics, Activism, and Community"(Oregon State University PhD Thesis 2007)
*
Michael Gordin
Michael Dan Gordin (born November 3, 1974) is an American science historian and Slavist.
Born in New Jersey, Gordin studied at Harvard University with a bachelor's degree in 1996 and a doctorate in 2001. From 2003 he was at Princeton University, ...
''How Lysenkoism Became Pseudoscience: Dobzhansky to Velikovsky'', Journal of the History of Biology (2012) 45:443-468.
* M. Gormley
"Scientific Discrimination and the Activist Scientist" ''J. Hist. Biol.'', v.42, n.1, pp. 33–72 (Spring 2009).
*
Mary F. Lyon
Mary Frances Lyon (15 May 1925 – 25 December 2014) was an English geneticist best known for her discovery of X-chromosome inactivation, an important biological phenomenon.
Early life and education
Mary Lyon was born on 15 May 1925 in Norwic ...
"L. C. Dunn and Mouse Genetic Mapping" ''Genetics'' (1990). "Perspectives: Anecdotal, Historical and Critical Commentaries on Genetics", edited by James F. Crow and William F. Dove.
A Guide to the Genetics Collections at the
American Philosophical Society: Major Collections. See als
L. C. Dunn Papers - Table of Contents
{{DEFAULTSORT:Dunn, L. C.
American geneticists
Columbia University