Kenneth Blackfan
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Kenneth Blackfan (September 9, 1883 – November 29, 1941) was an American
pediatrician Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the ...
. He took particular interest in nutrition and
hematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...
. A childhood blood disorder,
Diamond–Blackfan anemia Diamond–Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. DBA causes low red blood cell counts (anemia), without substantially affecting the other blood components (the platelets and the white blood cel ...
, is partly named after him. Early in his career, Blackfan did work that identified the origin of
cerebrospinal fluid Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the bra ...
.


Biography

Blackfan was born on September 9, 1883 in Cambridge, New York. He began his medical studies at the Albany Medical School of Union University, New York, graduating at the age of only 22. Initially, he returned home to join his father in general practice. He became bored with this, however, and four years later in 1909 he returned to Albany seeking fresh challenges. Encouraged by
Richard Pearse Richard William Pearse (3 December 187729 July 1953) was a New Zealand farmer and inventor who performed pioneering aviation experiments. Witnesses interviewed many years afterward describe observing Pearse flying and landing a powered heavie ...
, he decided to do some pediatric training in the Founding Hospital in Philadelphia. He did a residency under
John Howland John Howland (February 23, 1673) accompanied the English Separatists and other passengers when they left England on the to settle in Plymouth Colony. He was an indentured servant and in later years an executive assistant and personal secretary ...
starting in 1911 at
Washington University in St. Louis Washington University in St. Louis (WashU or WUSTL) is a private research university with its main campus in St. Louis County, and Clayton, Missouri. Founded in 1853, the university is named after George Washington. Washington University is r ...
, and in 1913 Blackfan followed Howland to
Johns Hopkins Hospital The Johns Hopkins Hospital (JHH) is the teaching hospital and biomedical research facility of the Johns Hopkins School of Medicine, located in Baltimore, Maryland, U.S. It was founded in 1889 using money from a bequest of over $7 million (1873 mo ...
in Baltimore. Here he worked with
Walter Dandy Walter Edward Dandy (April 6, 1886 – April 19, 1946) was an American neurosurgeon and scientist. He is considered one of the founding fathers of neurosurgery, along with Victor Horsley (1857–1916) and Harvey Cushing (1869–1939). Dandy is ...
(described of the Dandy–Walker syndrome) on internal
hydrocephalus Hydrocephalus is a condition in which an accumulation of cerebrospinal fluid (CSF) occurs within the brain. This typically causes increased intracranial pressure, pressure inside the skull. Older people may have headaches, double vision, poor ...
. Walker and Blackfan discovered where
cerebrospinal fluid Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates. CSF is produced by specialised ependymal cells in the choroid plexus of the ventricles of the bra ...
originated by tracking dye injected into the cerebral ventricle of a dog. Blackfan eventually became an associate professor of pediatrics at Johns Hopkins Hospital in 1918, then moved to
Cincinnati Children's Hospital Medical Center Cincinnati Children's Hospital Medical Center (CCHMC) is an academic pediatric acute care children's hospital located in the Pill Hill neighborhood of Cincinnati, Ohio. The hospital has 652 pediatric beds and is affiliated with the University of ...
and finally to
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
where he became director of clinical services at
Children's Hospital A children's hospital is a hospital that offers its services exclusively to infants, children, adolescents, and young adults. In certain special cases, they may also treat adults. The number of children's hospitals proliferated in the 20th ...
and professor of pediatrics. He occupied this position until his death in 1941. At Harvard, his main interests were
nutrition Nutrition is the biochemical and physiological process by which an organism uses food to support its life. It provides organisms with nutrients, which can be metabolized to create energy and chemical structures. Failure to obtain sufficient n ...
and
hematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...
. He was Louis K. Diamond’s mentor, and together they wrote the first collection of photographs of microscopic appearances of the Blood in Childhood disease. In 1938, they described Diamond–Blackfan syndrome. He also mentored
Sidney Farber Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other c ...
, the father of modern cancer chemotherapy, after whom is named the
Dana–Farber Cancer Institute Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated b ...
in Boston. Blackfan died of lung cancer in 1941 at the height of his career. Boston Children's Hospital is in front o
Blackfan Circle
which is named after Blackfan.


References

* "Inherited bone marrow failure: the men behind the empty space". Owen P. Smith & John Cox, ''British Journal of Haematology'', Volume 107 Page 242 - November 1999 {{DEFAULTSORT:Blackfan, Kenneth 1883 births 1941 deaths American pediatricians Johns Hopkins Hospital physicians Harvard Medical School faculty Albany Medical College alumni People from Cambridge, New York Physicians from Albany, New York Deaths from lung cancer in Kentucky