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Dana–Farber Cancer Institute
Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by the National Cancer Institute, and one of the 15 clinical affiliates and research institutes of Harvard Medical School. As of 2021, Dana–Farber is ranked the #3 cancer hospital in the world. Two Nobel laureates in Physiology or Medicine are among its past and present faculty. Dana–Farber's research discoveries include the development of the highly successful Gleevec to treat chronic myeloid leukemia. Overview Dana–Farber employs more than 4,855 full-time and part-time people, 529 faculty, and has annual gross revenues of about $1,733,386,000. All faculty and postdoctoral research fellows at Dana–Farber hold the equivalent academic positions concurrently at Harvard University. There are more than 523,425 adult and pediatric patie ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston
Boston (), officially the City of Boston, is the state capital and most populous city of the Commonwealth of Massachusetts, as well as the cultural and financial center of the New England region of the United States. It is the 24th- most populous city in the country. The city boundaries encompass an area of about and a population of 675,647 as of 2020. It is the seat of Suffolk County (although the county government was disbanded on July 1, 1999). The city is the economic and cultural anchor of a substantially larger metropolitan area known as Greater Boston, a metropolitan statistical area (MSA) home to a census-estimated 4.8 million people in 2016 and ranking as the tenth-largest MSA in the country. A broader combined statistical area (CSA), generally corresponding to the commuting area and including Providence, Rhode Island, is home to approximately 8.2 million people, making it the sixth most populous in the United States. Boston is one of the oldest ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Massachusetts General Hospital
Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United States and has a capacity of 999 beds. With Brigham and Women's Hospital, it is one of the two founding members of Mass General Brigham (formerly known as Partners HealthCare), the largest healthcare provider in Massachusetts. Massachusetts General Hospital houses the largest hospital-based research program in the world, the Mass General Research Institute, with an annual research budget of more than $1 billion in 2019. It is currently ranked as the #8 best hospital in the United States by '' U.S. News & World Report''. In , ''The Boston Globe'' ranked MGH the fifth best place to work out of Massachusetts companies with over 1,000 employees. History Founded in 1811, the original hospital was designed by the famous American architect Char ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aminopterin
Aminopterin (or 4-aminopteroic acid), the 4-amino derivative of folic acid, is an antineoplastic drug with immunosuppressive properties often used in chemotherapy. Aminopterin is a synthetic derivative of pterin. Aminopterin works as an enzyme inhibitor by competing for the folate binding site of the enzyme dihydrofolate reductase. Its binding affinity for dihydrofolate reductase effectively blocks tetrahydrofolate synthesis. This results in the depletion of nucleotide precursors and inhibition of DNA, RNA, and protein synthesis. It is classified as an extremely hazardous substance in the United States as defined in Section 302 of the U.S. Emergency Planning and Community Right-to-Know Act (42 U.S.C. 11002), and is subject to strict reporting requirements by facilities which produce, store, or use it in significant quantities. Uses Discovered by Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with leukemia. Aminopter ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Acute Lymphocytic Leukemia
Acute lymphoblastic leukemia (ALL) is a cancer of the lymphoid line of blood cells characterized by the development of large numbers of immature lymphocytes. Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain. As an acute leukemia, ALL progresses rapidly and is typically fatal within weeks or months if left untreated. In most cases, the cause is unknown. Genetic risk factors may include Down syndrome, Li-Fraumeni syndrome, or neurofibromatosis type 1. Environmental risk factors may include significant radiation exposure or prior chemotherapy. Evidence regarding electromagnetic fields or pesticides is unclear. Some hypothesize that an abnormal immune response to a common infection may be a trigger. The underlying mechanism involves multiple genetic mutations that results in rapid cell division. The excessive immature lymphocytes in the bone marrow interfere with the production of new red blood cells, whi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MPS Capital Services
MPS Capital Services Banca per le Imprese S.p.A. known as MPSCS in short, is an Italian corporate and investment bank based in Florence, Tuscany. The bank is a subsidiary of Banca Monte dei Paschi di Siena (Banca MPS). The subsidiary was known as MPS Banca per l'Impresa until 2007. On 28 March 2012 the bank was one of the banks that were selected to manage Fondo di Garanzia per le Piccole e Medie Imprese (a guarantee fund for SMEs) of the Ministry of Economic Development in a 9-year contract. (other banks were Mediocredito Italiano, Artigiancassa, Istituto Centrale delle Banche Popolari Italiane and Banca del Mezzogiorno – MedioCredito Centrale) History MPS Banca per l'Impresa was a merger of the two subsidiaries of Banca Monte dei Paschi di Siena: MPS Merchant and MPS Banca Verde (ex-Istituto Federale di Credito Agrario per la Toscana or Istituto Nazionale di Credito Agrario S.p.A. (INCA)) in 2004. The history of MPS Merchant – Banca per Piccole e Medie Imprese (found 200 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Boston Business Journal
The ''Boston Business Journal'' is a weekly, business-oriented newspaper published in Boston, Massachusetts. It is published by the American City Business Journals. The newspaper was founded by Robert Bergenheim and launched its first issue on March 2, 1981. The newspaper was originally named "P&L The Boston Business Journal" ("P&L" stood for profit and loss). However, "P&L" was later dropped from the name. Bergenheim was a former publisher of the Boston Herald. Before that, he was an editor at ''The Christian Science Monitor''. See also *List of newspapers in Massachusetts This is a list of newspapers in Massachusetts, including print and online. Daily newspapers :''This is a list of daily newspapers currently published in Massachusetts. For weekly newspapers, see List of newspapers in Massachusetts.'' No ... References Business newspapers published in the United States Newspapers published in Boston 1981 establishments in Massachusetts Newspapers estab ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Spanish Language
Spanish ( or , Castilian) is a Romance languages, Romance language of the Indo-European language family that evolved from colloquial Latin spoken on the Iberian peninsula. Today, it is a world language, global language with more than 500 million native speakers, mainly in the Americas and Spain. Spanish is the official language of List of countries where Spanish is an official language, 20 countries. It is the world's list of languages by number of native speakers, second-most spoken native language after Mandarin Chinese; the world's list of languages by total number of speakers, fourth-most spoken language overall after English language, English, Mandarin Chinese, and Hindustani language, Hindustani (Hindi-Urdu); and the world's most widely spoken Romance languages, Romance language. The largest population of native speakers is in Mexico. Spanish is part of the Iberian Romance languages, Ibero-Romance group of languages, which evolved from several dialects of Vulgar Latin in I ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chinese Language
Chinese (, especially when referring to written Chinese) is a group of languages spoken natively by the ethnic Han Chinese majority and many minority ethnic groups in Greater China. About 1.3 billion people (or approximately 16% of the world's population) speak a variety of Chinese as their first language. Chinese languages form the Sinitic branch of the Sino-Tibetan languages family. The spoken varieties of Chinese are usually considered by native speakers to be variants of a single language. However, their lack of mutual intelligibility means they are sometimes considered separate languages in a family. Investigation of the historical relationships among the varieties of Chinese is ongoing. Currently, most classifications posit 7 to 13 main regional groups based on phonetic developments from Middle Chinese, of which the most spoken by far is Mandarin (with about 800 million speakers, or 66%), followed by Min (75 million, e.g. Southern Min), Wu (74 million, e.g. Shangh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles A
Charles is a masculine given name predominantly found in English and French speaking countries. It is from the French form ''Charles'' of the Proto-Germanic name (in runic alphabet) or ''*karilaz'' (in Latin alphabet), whose meaning was "free man". The Old English descendant of this word was '' Ċearl'' or ''Ċeorl'', as the name of King Cearl of Mercia, that disappeared after the Norman conquest of England. The name was notably borne by Charlemagne (Charles the Great), and was at the time Latinized as ''Karolus'' (as in ''Vita Karoli Magni''), later also as '' Carolus''. Some Germanic languages, for example Dutch and German, have retained the word in two separate senses. In the particular case of Dutch, ''Karel'' refers to the given name, whereas the noun ''kerel'' means "a bloke, fellow, man". Etymology The name's etymology is a Common Germanic noun ''*karilaz'' meaning "free man", which survives in English as churl (< Old English ''ċeorl''), which developed its depr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sidney Farber
Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other chemotherapeutic agents against other malignancies. Farber was also active in cancer research advocacy and fundraising, most notably through his establishment of the Jimmy Fund, a foundation dedicated to pediatric research in childhood cancers. The Dana–Farber Cancer Institute is named after him. Early life He was born in Buffalo, New York, to Jewish parents Simon and Matilda (Goldstein) Farber. He was the third of 14 children. He was the younger brother of the noted philosopher and University of Buffalo professor Marvin Farber (1901–1980). Farber graduated from University at Buffalo, The State University of New York, or SUNY Buffalo, in 1923. Farber Hall, built in 1953 on the South Campus of SUNY Buffalo, is named for him. In the m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Forbes
''Forbes'' () is an American business magazine owned by Integrated Whale Media Investments and the Forbes family. Published eight times a year, it features articles on finance, industry, investing, and marketing topics. ''Forbes'' also reports on related subjects such as technology, communications, science, politics, and law. It is based in Jersey City, New Jersey. Competitors in the national business magazine category include ''Fortune'' and ''Bloomberg Businessweek''. ''Forbes'' has an international edition in Asia as well as editions produced under license in 27 countries and regions worldwide. The magazine is well known for its lists and rankings, including of the richest Americans (the Forbes 400), of the America's Wealthiest Celebrities, of the world's top companies (the Forbes Global 2000), Forbes list of the World's Most Powerful People, and The World's Billionaires. The motto of ''Forbes'' magazine is "Change the World". Its chair and editor-in-chief is Steve Fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laurie Glimcher
Laurie Hollis Glimcher (born 1951) is an American physician-scientist who was appointed president and CEO of Dana–Farber Cancer Institute in October 2016. She was elected a Member of the American Philosophical Society in 2019. Education Glimcher graduated from the Winsor School, an all-girls private school in Boston, Massachusetts, in 1968. In 1972, she graduated magna cum laude from Radcliffe College of Harvard University, and graduated cum laude from Harvard Medical School in 1976. Work She joined the board of directors of Bristol-Myers Squibb in 1997 and retired from the board in 2017. Her research laboratory received funding from Merck & Co for a project focused on developing new therapies for the treatment of osteoporosis in 2008. From 1991 to 2011, Glimcher was the Irene Heinz Given Professor of Immunology at the Harvard School of Public Health, a professor of medicine at Harvard Medical School. Clinically, she is a specialist in osteoporosis. From 2012 to 2016 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
