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Jean Golding , FMedSci, (born Jean Bond 22 September 1939, also known as Jean Fedrick between 1962 and 1977) is a British
epidemiologist Epidemiology is the study and analysis of the distribution (who, when, and where), patterns and determinants of health and disease conditions in a defined population. It is a cornerstone of public health, and shapes policy decisions and evidenc ...
, and founder of the
Avon Longitudinal Study of Parents and Children The Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s and formerly the Avon Longitudinal Study of Pregnancy and Childhood, is a cohort study of children born in the former county of Avon, England during 1 ...
(ALSPAC), also known as "Children of the Nineties". She is Emeritus Professor of Paediatric and Perinatal Epidemiology at the University of Bristol.


Early life and education

Born in Hayle, Cornwall in 1939, Golding struggled with illness throughout her childhood. Her regular stays in hospital led to a delay in the beginning of her education, eventually starting school when she was six years old. Her family moved to Chester, after a period living in Plymouth, and within a few weeks she contracted
polio Poliomyelitis, commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 70% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe s ...
, causing her to miss another year of school and causing a disability that would remain with her permanently. Despite these interruptions to her schooling, she won a place studying mathematics at St Anne's College, Oxford in 1958, from where she was awarded an honours BA, and subsequently MA.


Career and research

In 1966 she joined a team in London, headed by Neville Butler and Eva Alberman, analysing data collected in the 1958 Perinatal Mortality Survey (later the 1958 birth cohort)
British birth cohort studies Birth cohort studies in Britain include four long-term medical and social studies, carried out over the lives of a group of participants, from birth. Two of these studies have continued for over 50 years. Principal cohort studies * National Surve ...
. She then obtained a research fellowship in the Galton Laboratory of Human Genetics and Biometry, University College London
Galton Laboratory The Galton Laboratory was a laboratory for research into eugenics and then into human genetics based at University College London in London, England. It was originally established in 1904, and became part of UCL's biology department in 1996. The a ...
to study the aetiology of neural tube defects. Subsequent research at the
University of Oxford , mottoeng = The Lord is my light , established = , endowment = £6.1 billion (including colleges) (2019) , budget = £2.145 billion (2019–20) , chancellor ...
, involved working with large data sets including the Oxford Record Linkage Study. In 1980 she moved to the
University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...
, where she was involved in analysing data from the national 1970 birth cohort
British birth cohort studies Birth cohort studies in Britain include four long-term medical and social studies, carried out over the lives of a group of participants, from birth. Two of these studies have continued for over 50 years. Principal cohort studies * National Surve ...
. During the 1980s she was responsible for assisting in designing and augmenting a major perinatal survey in Jamaica 1985-6, and developed, and was the initial Director of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC). This led to the founding of ALSPAC (
Avon Longitudinal Study of Parents and Children The Avon Longitudinal Study of Parents and Children (ALSPAC), also known as Children of the 90s and formerly the Avon Longitudinal Study of Pregnancy and Childhood, is a cohort study of children born in the former county of Avon, England during 1 ...
), also known as Children of the 90s, a birth
cohort study A cohort study is a particular form of longitudinal study that samples a cohort (a group of people who share a defining characteristic, typically those who experienced a common event in a selected period, such as birth or graduation), performing ...
, the overall aim of which is to determine the ways in which different aspects of the environment influence child health and development, and how these may be influenced by genetics. The study has resulted in a highly detailed dataset of children born in the Avon area in 1991 and 1992, their parents and, as time has gone on, their own children. It continues to record biological, psychological, social and medical information of these groups throughout their childhoods and into their adult lives ALSPAC. The dataset is used by researchers across the world, and it includes interviews, questionnaires, biological samples, hands-on testing and linkage to educational and other records. Data collection has continued since the children were born. Golding's decision on what data was useful to collect has led to it being used for genetic and
Epigenetics In biology, epigenetics is the study of stable phenotypic changes (known as ''marks'') that do not involve alterations in the DNA sequence. The Greek prefix '' epi-'' ( "over, outside of, around") in ''epigenetics'' implies features that are ...
research worldwide, and, by 2019, around 2000 peer-reviewed papers based on this resource have been published (see ALSPAC website: www.bristol.ac.uk/alspac/). In 1987 she was the founding editor of the international journal: Paediatric and Perinatal Epidemiology and continued as editor-in-chief until 2012. Golding has continued to carry out research on the ALSPAC resource long into retirement, and has concentrated in particular with the psychologist, Professor Stephen Nowicki, at
Emory University Emory University is a private research university in Atlanta, Georgia. Founded in 1836 as "Emory College" by the Methodist Episcopal Church and named in honor of Methodist bishop John Emory, Emory is the second-oldest private institution of ...
, on the
Locus of control Locus of control is the degree to which people believe that they, as opposed to external forces (beyond their influence), have control over the outcome of events in their lives. The concept was developed by Julian B. Rotter in 1954, and has sinc ...
of the parents and children and how that appears to influence behaviours, and with Professor Marcus Pembrey on various trans- and inter-generational
Transgenerational epigenetic inheritance Transgenerational epigenetic inheritance is the transmission of epigenetic markers from one organism to the next (i.e., from parent to child) that affects the traits of offspring without altering the primary structure of DNA (i.e. the sequence of ...
influences on outcomes of various sorts.


Awards and honours

In 2012 she was made an Officer of the Order of the British Empire for services to medical science. In 2013, she received an honorary Doctor of Laws degree from the
University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...
, acclaimed as an "exemplar of the qualities and values the institution promotes". In 2016, the
University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...
created the Jean Golding Institute, a multidisciplinary data science and data-intensive research hub, in honour of her work as a mathematician, epidemiologist and founder of the Children of the 90s cohort study. In 2017, she received an honorary Doctor of Science from
University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...
for her pioneering work on longitudinal population studies. In 2018, as a celebration of the 70 years since the start of the NHS, she was made one of seven "NHS Research Legends". In 2018, the
University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...
honoured its pioneering women in suffrage centenary portraits, which were unveiled as part of the 'Women and equality: the next 100 years' event. Kate Robson Brown, the Director of th
Jean Golding Institute
holding a portrait of Jean Golding OBE. Again in 2018, in response to a national call by
English Heritage English Heritage (officially the English Heritage Trust) is a charity that manages over 400 historic monuments, buildings and places. These include prehistoric sites, medieval castles, Roman forts and country houses. The charity states that i ...
Put her Forward campaign (in response to the realisation of the paucity of statues of women in Britain), Golding was nominated, and among 25 women to have a 3-D printed statuette. This is currently displayed in the Royal Fort House at the University of Bristol. On 18 November 2022, she was the guest of an episode of ''
Desert Island Discs ''Desert Island Discs'' is a radio programme broadcast on BBC Radio 4. It was first broadcast on the BBC Forces Programme on 29 January 1942. Each week a guest, called a "castaway" during the programme, is asked to choose eight recordings (usua ...
''.


References


External links

* {{DEFAULTSORT:Golding, Jean Living people 1939 births People from Hayle Alumni of St Anne's College, Oxford British epidemiologists Officers of the Order of the British Empire Academic journal editors