James Lorrain Smith FRS FRSE

FRCPE The Royal College of Physicians of Edinburgh (RCPE) is a medical royal college in Scotland. It is one of three organisations that sets the specialty training standards for physicians in the United Kingdom. It was established by Royal charter ...

(21 August 1862 – 18 April 1931) was a Scottish

pathologist Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in t ...

known for his works in human

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

, especially his research on respiration in collaboration with

John Scott Haldane John Scott Haldane (; 2 May 1860 – 14/15 March 1936) was a British physician and physiologist famous for intrepid self-experimentation which led to many important discoveries about the human body and the nature of gases. He also experimen ...

Life

He was born in the manse at Half Morton in rural

Dumfriesshire Dumfriesshire or the County of Dumfries or Shire of Dumfries (''Siorrachd Dhùn Phris'' in Gaelic) is a historic county and registration county in southern Scotland. The Dumfries lieutenancy area covers a similar area to the historic county. I ...

the fourth son of Rev Walter Smith who was a Free Church of Scotland minister in the parish. He had several talented siblings, including the mycologist,

Annie Lorrain Smith Annie Lorrain Smith (23 October 1854 – 7 September 1937) was a British lichenologist whose ''Lichens'' (1921) was an essential textbook for several decades. She was also a mycologist and founder member of the British Mycological Society, wh ...

who worked informally at the British Museum. His brother Walter Smith became a professor of philosophy at

Lake Forest College Lake Forest College is a private liberal arts college in Lake Forest, Illinois. Founded in 1857 as Lind University by a group of Presbyterian ministers, the college has been coeducational since 1876 and an undergraduate-focused liberal arts i ...

Illinois Illinois ( ) is a state in the Midwestern United States. Its largest metropolitan areas include the Chicago metropolitan area, and the Metro East section, of Greater St. Louis. Other smaller metropolitan areas include, Peoria and Rockf ...

whilst another brother, William George Smith, became a lecturer in psychology. Lorrain Smith was educated locally then at

George Watson's College George Watson's College is a co-educational independent day school in Scotland, situated on Colinton Road, in the Merchiston area of Edinburgh. It was first established as a hospital school in 1741, became a day school in 1871, and was merg ...

Edinburgh Edinburgh ( ; gd, Dùn Èideann ) is the capital city of Scotland and one of its 32 council areas. Historically part of the county of Midlothian (interchangeably Edinburghshire before 1921), it is located in Lothian on the southern shore of t ...

. He studied for a general Arts, graduating with an MA in 1893 and allowing him to then study medicine at the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 15 ...

where he graduated with an

MB ChB Bachelor of Medicine, Bachelor of Surgery ( la, Medicinae Baccalaureus, Baccalaureus Chirurgiae; abbreviated most commonly MBBS), is the primary medical degree awarded by medical schools in countries that follow the tradition of the United King ...

in 1889. He then studied

pathology Pathology is the study of the causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in ...

as a postgraduate under Prof John Lucas Walker at the

University of Cambridge The University of Cambridge is a public collegiate research university in Cambridge, England. Founded in 1209 and granted a royal charter by Henry III in 1231, Cambridge is the world's third oldest surviving university and one of its most pr ...

. He became a Demonstrator under Professor Charles Smart Roy who recommended that he follow his studies at the universities of Strasbourg under

Friedrich Daniel von Recklinghausen Friedrich Daniel von Recklinghausen (; December 2, 1833 – August 26, 1910) was a German pathologist born in Gütersloh, Westphalia. He was the father of physiologist Heinrich von Recklinghausen (1867–1942). Early life Recklinghausen was bo ...

. He spent some time at

Copenhagen Copenhagen ( or .; da, København ) is the capital and most populous city of Denmark, with a proper population of around 815.000 in the last quarter of 2022; and some 1.370,000 in the urban area; and the wider Copenhagen metropolitan ar ...

where he studied techniques for analysing gases in blood in

Christian Bohr Christian Harald Lauritz Peter Emil Bohr (1855–1911) was a Danish physician, father of the physicist and Nobel laureate Niels Bohr, as well as the mathematician and football player Harald Bohr and grandfather of another physicist and Nobel lau ...

's laboratory before moving to teach at the

Queen's College, Belfast , mottoeng = For so much, what shall we give back? , top_free_label = , top_free = , top_free_label1 = , top_free1 = , top_free_label2 = , top_free2 = , established = , closed = , type = Public research university , parent = ...

, becoming a professor in 1901. In 1904 he was elected President of the Ulster Medical Association. In 1904 he became Professor of Pathology at the

University of Manchester , mottoeng = Knowledge, Wisdom, Humanity , established = 2004 – University of Manchester Predecessor institutions: 1956 – UMIST (as university college; university 1994) 1904 – Victoria University of Manchester 1880 – Victoria Univ ...

and in 1912 moved to the

to replace Prof William Smith Greenfield. During the

First World War World War I (28 July 1914 11 November 1918), often abbreviated as WWI, was one of the deadliest global conflicts in history. Belligerents included much of Europe, the Russian Empire, the United States, and the Ottoman Empire, with fightin ...

he helped to introduce the antiseptic " Eusol" (Edinburgh University Solution) and suggested the idea of using charcoal in gas masks. Lorrain Smith worked with

respiration Respiration may refer to: Biology * Cellular respiration, the process in which nutrients are converted into useful energy in a cell ** Anaerobic respiration, cellular respiration without oxygen ** Maintenance respiration, the amount of cellul ...

particularly the transport of

oxygen Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as ...

by the

blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the cir ...

. The pulmonary condition of intoxication due to excess oxygen or

oxygen toxicity Oxygen toxicity is a condition resulting from the harmful effects of breathing molecular oxygen () at increased partial pressures. Severe cases can result in cell damage and death, with effects most often seen in the central nervous system, lu ...

is sometimes called " Lorrain Smith effect". He was elected a Fellow of the

Royal Society of London The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...

on 6 May 1909. In 1919 he was elected a Fellow of the Royal Society of Edinburgh. His proposers were

Sir William Turner Sir William Turner (7 January 1832, in Lancaster, Lancashire, Lancaster – 15 February 1916, in Edinburgh) was an English anatomist and was the Principal of the University of Edinburgh from 1903 to 1916. Life Turner was born in Lancaster ...

Cargill Gilston Knott Cargill Gilston Knott FRS, FRSE LLD (30 June 1856 – 26 October 1922) was a Scottish physicist and mathematician who was a pioneer in seismological research. He spent his early career in Japan. He later became a Fellow of the Royal Society, ...

, Sir Edmund Taylor Whittaker and Arthur Robinson. He died on 18 April 1931. A memorial ceremony was held at the University of Edinburgh read by Principal David Cairns. He was cremated at

Warriston Crematorium Warriston ( ) is a suburb of Edinburgh, the capital of Scotland. It lies east of the Royal Botanic Garden in Inverleith. The name derives from Warriston House, a local mansion house demolished in 1966. In July 1600 John Kincaid, the Laird of ...

Family

In 1895 he married Isabella Edmond.

Publications

References

{{DEFAULTSORT:Smith, James Lorrain 1862 births 1931 deaths People from Dumfries and Galloway Alumni of the University of Edinburgh University of Strasbourg alumni University of Copenhagen alumni Academics of Queen's University Belfast Scottish pathologists Fellows of the Royal Society People educated at George Watson's College Fellows of the Royal Society of Edinburgh