Itsik Pe'er is a computational biologist and a Full Professor in the Department of Computer Science at

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

Research and career

Pe'er has created computational tools for the analysis of high-throughput DNA sequence data. In particular, he has developed an approach to map

copy number variation Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals. Copy number variation is a type of structural variation: specifically, it is a type of d ...

from

whole exome sequencing Exome sequencing, also known as whole exome sequencing (WES), is a genomic technique for sequencing all of the protein-coding regions of genes in a genome (known as the exome). It consists of two steps: the first step is to select only the subset ...

data. He has published approaches to quantify hidden relatedness and infer population structure using DNA data. He has conducted studies on the genetics of complex traits in

Ashkenazi Jews Ashkenazi Jews ( ; he, יְהוּדֵי אַשְׁכְּנַז, translit=Yehudei Ashkenaz, ; yi, אַשכּנזישע ייִדן, Ashkenazishe Yidn), also known as Ashkenazic Jews or ''Ashkenazim'',, Ashkenazi Hebrew pronunciation: , singu ...

, historically a relatively isolated population enabling identification of genetic risk factors for common disorders in all populations. He is generating a comprehensive resource of genetic variants in the population for precision public health.

Selected publications

* Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. I Pe'er, R Yelensky, D Altshuler, MJ Daly ''Genetic Epidemiology''. 32(4):381-5. doi:10.1002/gepi.20303 * Evaluating and improving power in whole-genome association studies using fixed marker sets. I Pe'er, PIW de Bakker, J Maller, R Yelensky, D Altshuler, MJ Daly ''Nature Genetics''. 38(6):663-667. doi:10.1038/ng1816 * Sequencing an Ashkenazi reference panel supports population-targeted personal genomics and illuminates Jewish and European origins. Shai Carmi, Ken Y Hui, Ethan Kochav, Xinmin Liu, James Xue, Fillan Grady, Saurav Guha, Kinnari Upadhyay, Dan Ben-Avraham, Semanti Mukherjee, B Monica Bowen, Tinu Thomas, Joseph Vijai, Marc Cruts, Guy Froyen, Diether Lambrechts, Stéphane Plaisance, Christine Van Broeckhoven, Philip Van Damme, Herwig Van Marck, Nir Barzilai, Ariel Darvasi, Kenneth Offit, Susan Bressman, Laurie J Ozelius, Inga Peter, Judy H Cho, Harry Ostrer, Gil Atzmon, Lorraine N Clark, Todd Lencz, Itsik Pe’er. ''Nature Communications''. doi:10.1038/ncomms5835

Personal life

Itsik Pe'er is married to

Dana Pe'er Dana Pe'er (born 1971), Chair and Professor in Computational and Systems Biology Program at Sloan Kettering Institute is a researcher in computational systems biology. A Howard Hughes Medical Institute (HHMI) Investigator since 2021, she was prev ...

, a computational biologist at Sloan Kettering Institute.

References

External links

*
Faculty page, The Fu Foundation School of Engineering and Applied Science, Columbia University
{{DEFAULTSORT:Pe'er, Itsik Statistical_geneticists Year of birth missing (living people) Living people Columbia University faculty Tel Aviv University alumni American bioinformaticians