Irving M. London (July 24, 1918 – May 23, 2018) was a
hematologist
Hematology (American and British English spelling differences#ae and oe, always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to ...
and
geneticist. He was an associate professor of medicine at
Columbia University College of Physicians and Surgeons when he was selected to be the founding chair of the department of medicine at the
Albert Einstein College of Medicine in 1955. He was recruited to become the founding director of the
Harvard-MIT Program in Health Sciences and Technology in 1970. Dr. London was the first professor to hold dual roles at both Harvard and MIT.
London graduated from
Harvard College and
Harvard Medical School. London died on May 23, 2018, two months before his 100th birthday.
Family and early life
London was born in
Malden, Massachusetts
Malden is a city in Middlesex County, Massachusetts, United States. At the time of the 2020 U.S. Census, the population was 66,263 people.
History
Malden, a hilly woodland area north of the Mystic River, was settled by Puritans in 1640 on la ...
on 24 July 1918. His parents identified as Russian Jewish.
His mother may have been named Rose London (1892-1944), and a sister named Marion.
In his childhood years, London had
polio. He completed his primary and secondary education at
Malden Public Schools
Malden Public Schools is a school district headquartered in Malden, Massachusetts in Greater Boston.
Dana Brown, the principal of Malden High School, stated that one reason why the schools of Malden Public Schools often have test scores higher ...
in
Massachusetts.
While in college, London worked at a library on a salary funded by the
National Youth Administration as part of the
New Deal
The New Deal was a series of programs, public work projects, financial reforms, and regulations enacted by President Franklin D. Roosevelt in the United States between 1933 and 1939. Major federal programs agencies included the Civilian Cons ...
during the
Great Depression
The Great Depression (19291939) was an economic shock that impacted most countries across the world. It was a period of economic depression that became evident after a major fall in stock prices in the United States. The economic contagio ...
era.
London married Huguette Piedzicki. They met in Paris and maintained a long-distance relationship until marriage. They had two Children, Robb and David, and many extended family members.
Career
London graduated from
Harvard College in 1939 ''summa cum laude''. He was on a student committee at Harvard that gave 14 refugee students the opportunity to leave
Nazi-occupied Europe to study in Boston.
London also earned a second undergraduate degree from
Hebrew College in
Roxbury Roxbury may refer to:
Places
;Canada
* Roxbury, Nova Scotia
* Roxbury, Prince Edward Island
;United States
* Roxbury, Connecticut
* Roxbury, Kansas
* Roxbury, Maine
* Roxbury, Boston, a municipality that was later integrated into the city of Bosto ...
at the same time.
London delivered the graduating address at Harvard, the content of which was inspired by his thesis "The Jeffersonian Tradition in American Nationalism".
London gave serious though to attending law school after graduation, but ultimately chose to enroll in medical school.
After completing an MD from HMS in 1943, Dr. London accepted an intership at
Columbia-Presbyterian Medical Center in New York. During
World War II he served as a US Army captain in the Medical Corps were he conducted research on the use of
chloroquine as an
antimalarial medication. After the war, he was assigned to
Bikini Atoll in the
Marshall Islands of the South
Pacific Ocean to serve a physician at the
atomic bomb testing.
London returned to New York City after the war to continue residency training. Upon completion, he joined the department of biochemistry at
Columbia University College of Physicians & Surgeons
Columbia University Vagelos College of Physicians and Surgeons (VP&S) is the graduate medical school of Columbia University, located at the Columbia University Irving Medical Center in the Washington Heights neighborhood of Manhattan. Founded i ...
and was promoted to faculty, teaching and tenure. His research focused on the lifespan of
red blood cells in normal and pathological conditions.
In 1954, he was selected to be the founding chair of the department of medicine at the
Albert Einstein College of Medicine, and was director of medical services at
Bronx Municipal Hospital
Jacobi Medical Center (NYC Health + Hospitals/Jacobi) is a municipal hospital operated by NYC Health + Hospitals in affiliation with the Albert Einstein College of Medicine. The facility is located in the Morris Park neighborhood of the Bronx, Ne ...
until 1970.
In 1968, London was invited as a consultant to planning for the
Massachusetts Institute of Technology and
Harvard Medical School joint program. In 1970 he accepted a position a director of the new
Harvard-MIT Program in Health Sciences and Technology, and around 1972 he was also a physician at
Peter Bent Brigham Hospital. London served as director of the program until 1985 while simultaneously a professor of medicine at HMS and a professor of biology at MIT.
Awards and achievements
London is best known for groundbreaking explanation for the molecular regulation (gene transcription and translation) of
hemoglobin synthesis.
London and colleagues demonstrated that hemoglobin is the endogenous source of
bilirubin
Bilirubin (BR) (Latin for "red bile") is a red-orange compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates. This catabolism is a necessary process in the body's clearance of waste products that arise from the ...
, an important event in the fields of
jaundice
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and sclera due to high bilirubin levels. Jaundice in adults is typically a sign indicating the presence of underlying diseases involving abnormal heme meta ...
and
heme oxygenase research.
* Welch Fellowship in Internal Medicine of the National Academy of Sciences 1949-1952
* Theobald Smith Award in Medical Sciences of the American Association for the Advancement of Science 1953
* Commonwealth Fund Fellowship at Institut Pasteur 1962-1963
* election to American Academy of Arts and Sciences 1963
* charter member in the Institute of Medicine of the National Academy of Sciences in 1970
* elected member National Academy of Science 1971
* board of directors for Biosciences Advisory Committee for
Johnson & Johnson
Johnson & Johnson (J&J) is an American multinational corporation founded in 1886 that develops medical devices, pharmaceuticals, and consumer packaged goods. Its common stock is a component of the Dow Jones Industrial Average and the company i ...
1982-2003
* establishment of The Irving M. London Society (HST) at Harvard Medical School
* The Dr. Irving M. London Teaching Award, initiated in 1986
References
{{DEFAULTSORT:London, Irving
1918 births
2018 deaths
Albert Einstein College of Medicine faculty
American hematologists
American geneticists
American people of Russian-Jewish descent
Columbia University faculty
Harvard Medical School alumni
Harvard University alumni
People from Malden, Massachusetts
Members of the National Academy of Medicine