Ipatasertib (RG7440) is an experimental cancer drug in development by
Roche
F. Hoffmann-La Roche AG, commonly known as Roche, is a Swiss multinational healthcare company that operates worldwide under two divisions: Pharmaceuticals and Diagnostics. Its holding company, Roche Holding AG, has shares listed on the SIX S ...
. It is a small molecule inhibitor of
AKT
Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transc ...
, which is a key component of the
PI3K/AKT pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle. Therefore, it is directly related to cellular quiescence, proliferation, cancer, and longevity. PI3K activation phosphorylates and activates A ...
. Ipatasertib was discovered by
Genentech
Genentech, Inc., is an American biotechnology corporation headquartered in South San Francisco, California. It became an independent subsidiary of Roche in 2009. Genentech Research and Early Development operates as an independent center within R ...
in collaboration with
Array Biopharma
Array BioPharma is an American clinical stage, pharmaceutical company that focuses on oncology medication headquartered in Boulder, Colorado. The company is a subsidiary of Pfizer.
History
In 1998, the company was founded by Drs. Tony Piscopio, K ...
and is currently in phase II trials for treatment of
breast cancer
Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...
.
In vitro, ipatasertib showed activity against all three isoforms of Akt.
References
{{reflist
Experimental cancer drugs
Drugs not assigned an ATC code
Protein kinase inhibitors
Chloroarenes
Piperazines
Isopropylamino compounds
Secondary alcohols