Interleukin 36 receptor antagonist (IL-36RA) is a member of the
interleukin-36 family of
cytokines
Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are peptides and cannot cross the lipid bilayer of cells to enter the cytoplasm. Cytokines have been shown to be involved in autocrin ...
. It was previously named Interleukin-1 family member 5 (IL1F5).
The protein is known to inhibit the effects of Interleukin-36 cytokines (
IL-36α,
IL-36β
Interleukin-36 beta also known as interleukin-1 family member 8 (IL1F8) is a protein that in humans is encoded by the ''IL36B'' gene.
Function
The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure ...
and
IL-36γ
Interleukin-36 gamma previously known as interleukin-1 family member 9 (IL1F9) is a protein that in humans is encoded by the ''IL36G'' gene.
Expression
''IL36G'' is well-expressed in the epithelium of the skin, gut, and lung. In the skin ''IL36G ...
) via competing with their receptor
IL-36R/IL1RL2 and thereby inhibiting their proinflammatory effects.
Roles in disease
Mutations in the IL-36RN gene resulting in a decrease or production of defective IL-36RA protein have been shown to cause inflammatory skin diseases including
generalised pustular psoriasis,
acrodermatitis continua suppurativa Hallopeau (ACH) and
acute generalized exanthematous pustulosis
Acute generalized exanthematous pustulosis (AGEP) (also known as pustular drug eruption and toxic pustuloderma) is a rare skin reaction that in 90% of cases is related to medication administration.
AGEP is characterized by sudden skin eruptions th ...
(AGEP).
References
Further reading
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
*
{{Interleukin receptor modulators
Cytokine receptors