Integrated DNA Technologies, Inc. (IDT), headquartered in

Coralville, Iowa Coralville is a city in Johnson County, Iowa, Johnson County, Iowa, United States. It is a suburb of Iowa City, Iowa, Iowa City and part of the Iowa City metropolitan area, Iowa City Metropolitan Statistical Area. The population was 22,318 at the 2 ...

, is a supplier of custom nucleic acids, serving the areas of academic research, biotechnology, clinical diagnostics, and pharmaceutical development. IDT's primary business is the manufacturing of custom DNA and

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

oligonucleotides Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics. Commonly made in the laboratory by solid-phase chemical synthesis, these small bits of nucleic acids c ...

(oligos) for research applications. Joseph A. Walder, M.D., Ph.D. (

Northwestern University Northwestern University is a private research university in Evanston, Illinois. Founded in 1851, Northwestern is the oldest chartered university in Illinois and is ranked among the most prestigious academic institutions in the world. Charte ...

), founded Integrated DNA Technologies, Inc. in 1987 through a partnership with

Baxter Healthcare Baxter International Inc. is an American multinational healthcare company with headquarters in Deerfield, Illinois. The company primarily focuses on products to treat kidney disease, and other chronic and acute medical conditions. The compan ...

Corporation at the

University of Iowa The University of Iowa (UI, U of I, UIowa, or simply Iowa) is a public university, public research university in Iowa City, Iowa, United States. Founded in 1847, it is the oldest and largest university in the state. The University of Iowa is org ...

Technology Innovation Center business incubator. In its first 10 years, IDT grew from a startup with 10 synthesizing machines to a small company with more than 500, shipping an average 75,000 custom oligos per day to more than 82,000 customers worldwide. In March 2018, IDT was acquired by

Danaher Corporation Danaher Corporation is an American globally diversified conglomerate with its headquarters in Washington, D.C. The company designs, manufactures, and markets professional, medical, industrial, and commercial products and services. The company's ...

for a reported $1.9 billion.

Mission

IDT's mission is to enable discovery in biology and medicine. The company strives to achieve this by improving nucleic acid synthesis technology and developing new applications for the use of DNA- and RNA-based compounds. IDT's advanced synthesis group combines expertise in chemistry, molecular biology, and engineering to produce and purify complex nucleic acids of all kinds.

SciTools

Synthetic oligonucleotides are used in various

molecular biology Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

applications, e.g.,

polymerase chain reaction The polymerase chain reaction (PCR) is a method widely used to rapidly make millions to billions of copies (complete or partial) of a specific DNA sample, allowing scientists to take a very small sample of DNA and amplify it (or a part of it) t ...

(PCR), molecular beacons,

microarrays A microarray is a multiplex lab-on-a-chip. Its purpose is to simultaneously detect the expression of thousands of genes from a sample (e.g. from a tissue). It is a two-dimensional array on a solid substrate—usually a glass slide or silicon t ...

, mutagenesis,

RNAi RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression by double-stranded RNA, through translational or transcriptional repression. Historically, RNAi was known by o ...

antisense In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids. Depending on the context, ...

and

gene synthesis Artificial gene synthesis, or simply gene synthesis, refers to a group of methods that are used in synthetic biology to construct and assemble genes from nucleotides '' de novo''. Unlike DNA synthesis in living cells, artificial gene synthesis do ...

. Published

bioinformatics Bioinformatics () is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when the data sets are large and complex. As an interdisciplinary field of science, bioinformatics combi ...

algorithms can predict biophysical properties of oligonucleotides from their sequence and estimate oligonucleotide performance in specific assays, when used singly or together with other sequences. IDT's ''SciTools'' is a free online suite of computational software tools that enable molecular biologists to design, evaluate and make informed decisions about the properties of nucleic acid sequences. Instructions and help to each software tool can be found at the top of web input forms. The code is regularly updated when more accurate models and algorithms are published.

Major product areas

Certifications

IDT earned its

ISO 9001 The ISO 9000 family is a set of five quality management systems (QMS) standards that help organizations ensure they meet customer and other stakeholder needs within statutory and regulatory requirements related to a product or service. ISO 90 ...

:2000 certification at its oligonucleotide production headquarters in 2005. IDT earned its

ISO 13485 ISO 13485 ''Medical devices -- Quality management systems -- Requirements for regulatory purposes'' is a voluntary standard, published by International Organization for Standardization (ISO) for the first time in 1996, and contains a comprehensive ...

:2003 certification for its Quality Management System in 2008.

References

External links

IDT Company Website

IDT SciTools
{{Authority control American companies established in 1987 Biotechnology companies established in 1987 Biotechnology companies of the United States Health care companies based in Iowa