IUCLID (; International Uniform Chemical Information Database) is a
software
Software is a set of computer programs and associated documentation and data. This is in contrast to hardware, from which the system is built and which actually performs the work.
At the lowest programming level, executable code consists ...
application to capture, store, maintain and exchange data on intrinsic and hazard properties of
chemical substance
A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., wi ...
s. Distributed free of charge, the software is especially useful to chemical industry companies and to government authorities. It is the key tool for chemical industry to fulfill data submission obligations under
REACH, the most important
European Union
The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe. The union has a total area of and an estimated total population of about 447million. The EU has often been des ...
legal document covering the production and use of chemical substances. The software is maintained by the
European Chemicals Agency
The European Chemicals Agency (ECHA; ) is an agency of the European Union which manages the technical and administrative aspects of the implementation of the European Union regulation called Registration, Evaluation, Authorisation and Restricti ...
, ECHA. The latest version, version 6, was made available on 29 April 2016.
History
IUCLID versions 1 to 4
1993: First version of IUCLID for the European Existing Substances Regulation 793/93/EEC.
1999: IUCLID becomes the recommended tool for the OECD HPV Programme.
2000: IUCLID is the software prescribed in the EU Biocides legislation to notify existing active substances (Art. 4 of Commission Regulation (EC) No 1896/2000).
IUCLID 4 was used worldwide by about 500 organizations. These included chemical industry companies,
EU Member State Competent Authorities, the
OECD
The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organisation with 38 member countries, founded in 1961 to stimulate e ...
Secretariat, the
US EPA
The Environmental Protection Agency (EPA) is an independent executive agency of the United States federal government tasked with environmental protection matters. President Richard Nixon proposed the establishment of EPA on July 9, 1970; it be ...
, the Japan
METI, and third party service providers.
IUCLID 5
In 2003, when it became clear that the REACH proposal would be adopted by the
European Union
The European Union (EU) is a supranational political and economic union of member states that are located primarily in Europe. The union has a total area of and an estimated total population of about 447million. The EU has often been des ...
, the
European Commission
The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
decided to completely overhaul IUCLID 4 and to create a new version, IUCLID 5, which would be used by chemical industry companies to fulfill their data submission obligations under
REACH. Migration of data in the IUCLID 4 format was supported by IUCLID 5.1. IUCLID 5.1 became available on 13 June 2007.
IUCLID is also mentioned in article 111 of the REACH of the REACH legislation as the format to be used for data collection and submission dossier preparation.
The following IUCLID 5 major versions have been released:
* IUCLID 5.0: 12 June 2007
* IUCLID 5.1: 16 January 2009
* IUCLID 5.2: 15 February 2010
* IUCLID 5.3: 24 February 2011
* IUCLID 5.4: 5 June 2012
* IUCLID 5.5: 2 April 2013
* IUCLID 5.6: 16 April 2014
IUCLID 5
Data Format and Exchange
Data that can be stored and maintained with IUCLID encompass information about:
* The party running IUCLID (production sites, contact persons etc.)
* The chemical substances managed by the company, namely their
** identity, composition, and supporting analytical data
** reference information like
CAS number and other identifiers,
**
classification and labelling
** physical/chemical properties,
**
toxicological
Toxicology is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating expos ...
properties,
**
eco-toxicological properties.
OECD
The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organisation with 38 member countries, founded in 1961 to stimulate e ...
and the European Commission have agreed on a standard
XML
Extensible Markup Language (XML) is a markup language and file format for storing, transmitting, and reconstructing arbitrary data. It defines a set of rules for encoding documents in a format that is both human-readable and machine-readable. T ...
format
OECD Harmonized Templates in which these data are stored for easy data sharing. IUCLID 5 will be the first application fully implementing this international reporting standard, which has been accepted by many national and international regulatory authorities.
Numerous parties were involved in the creation and the review of the OECD Harmonized Templates, among them th
Business and Industry Advisory Committee(BIAC) to the
OECD
The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organisation with 38 member countries, founded in 1961 to stimulate e ...
, the
European Chemical Industry Council
The European Chemical Industry Council or Cefic (from its former French name ''Conseil Européen des Fédérations de l'Industrie Chimique'') is the main European trade association for the chemical industry. It was founded in 1972. Its headquart ...
(CEFIC) and other bodies and authorities.
IUCLID5 can be used to enter
robust study summaries summarising toxicologically-relevant endpoints. A
Klimisch score The Klimisch score is a method of assessing the reliability of toxicological studies, mainly for regulatory purposes, that was proposed by H.J. Klimisch, M. Andreae and U. Tillmann of the chemical company BASF in 1997 in a paper entitled ''A Systema ...
is assigned within robust study summary as one field.
Possible IUCLID 5 uses
Anyone can use a local IUCLID 5 installation to collect, store, maintain and exchange relevant data on chemical substances.
In addition to dossier creation for REACH, IUCLID 5 data can be (re-)used for a large number of other purposes, due to the compatibility of IUCLID 5 data with th
OECD Harmonized Templates The
European Commission
The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
IUCLID project team and international authorities are currently in deliberation in order to further promote acceptance of IUCLID5 data in non-
REACH jurisdictions. Legislations and programmes under which IUCLID 5 data are certainly accepted are:
OECD Chemical Assessment ProgrammeUS HPV Challenge ProgrammeJapan HPV Challenge Programme(provided OECD guidance fo
dossiers is followed there).
The IUCLID 5 data model also features
Biocide
A biocide is defined in the European legislation as a chemical substance or microorganism intended to destroy, deter, render harmless, or exert a controlling effect on any harmful organism. The US Environmental Protection Agency (EPA) uses a slig ...
s/
Pesticide
Pesticides are substances that are meant to control pests. This includes herbicide, insecticide, nematicide, molluscicide, piscicide, avicide, rodenticide, bactericide, insect repellent, animal repellent, microbicide, fungicide, and lampri ...
s elements. A dataset prepared for a substance under
REACH can therefore be quickly complemented with data about possible biocidal or pesticidal properties and be re-used for data reporting obligations under the EU Biocides regulation.
The data are available and can be searched through th
OECD eChemPortal
Technology
IUCLID development and deployment
IUCLID 5 is a
Java
Java (; id, Jawa, ; jv, ꦗꦮ; su, ) is one of the Greater Sunda Islands in Indonesia. It is bordered by the Indian Ocean to the south and the Java Sea to the north. With a population of 151.6 million people, Java is the world's List ...
-based application, using the
Hibernate
Hibernation is a state of minimal activity and metabolic depression undergone by some animal species. Hibernation is a seasonal heterothermy characterized by low body-temperature, slow breathing and heart-rate, and low metabolic rate. It most ...
framework for
persistence. It features a
Java Swing graphical user interface (GUI) and can be deployed on both single workstation and distributed environments.
IUCLID 5 offers the possibility to be deployed in:
* either a 100%
open source
Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use the source code, design documents, or content of the product. The open-source model is a decentralized sof ...
system environment, using
Tomcat
Tomcat may refer to:
Animals
* A sexually mature male cat
* Paederus, known as in Indonesia
Science and technology
* Apache Tomcat, an implementation of Java web-server technologies
* Beretta 3032 Tomcat, a pistol
* Grumman F-14 Tomcat, a f ...
as
web container
A web container (also known as a servlet container;
and compare "webcontainer"
) is the component of a web server that interacts with Jakarta Servlets. A web container is responsible for managing the lifecycle of servlets, mapping a URL to a par ...
and
PostgreSQL
PostgreSQL (, ), also known as Postgres, is a free and open-source relational database management system (RDBMS) emphasizing extensibility and SQL compliance. It was originally named POSTGRES, referring to its origins as a successor to the In ...
as
Database Management System (DBMS),
* or a commercial system environment, using the
Oracle WebLogic Server
Oracle WebLogic Server is a Java EE application server currently developed by Oracle Corporation. Oracle acquired WebLogic Server when it purchased BEA Systems in 2008.
Application Server versions
* WebLogic Server 14c (14.1.1) - March 30, 20 ...
from
Oracle Corporation
Oracle Corporation is an American multinational computer technology corporation headquartered in Austin, Texas. In 2020, Oracle was the third-largest software company in the world by revenue and market capitalization. The company sells da ...
as
application server
An application server is a server that hosts applications or software that delivers a business application through a communication protocol.
An application server framework is a service layer model. It includes software components available to a ...
and/or
Oracle
An oracle is a person or agency considered to provide wise and insightful counsel or prophetic predictions, most notably including precognition of the future, inspired by deities. As such, it is a form of divination.
Description
The word '' ...
as
Database Management System (DBMS).
.i5z files
IUCLID 5 exports and imports files in the I5Z format. Files may be swapped between different IUCLID 5 installations and dossiers may be uploaded to
ECHA
The European Chemicals Agency (ECHA; ) is an agency of the European Union which manages the technical and administrative aspects of the implementation of the European Union regulation called Registration, Evaluation, Authorisation and Restrict ...
via
REACH-IT. I5Z stands for "IUCLID 5 Zip", as the file uses
Zip file
ZIP is an archive file format that supports lossless data compression. A ZIP file may contain one or more files or directories that may have been compressed. The ZIP file format permits a number of compression algorithms, though DEFLATE is th ...
compression.
IUCLID 5 system requirements
IUCLID can be deployed on any current PC. For optimal performance,
RAM
Ram, ram, or RAM may refer to:
Animals
* A male sheep
* Ram cichlid, a freshwater tropical fish
People
* Ram (given name)
* Ram (surname)
* Ram (director) (Ramsubramaniam), an Indian Tamil film director
* RAM (musician) (born 1974), Dutch
* ...
should not be less than 1 GB.
IUCLID 6
IUCLID 6 was made available on 24 June 2015 as a beta version so that large companies and other organisations could begin preparing their IT systems for the full release of IUCLID 6 in 2016. However, individual users and SMEs could also download the beta version to get a preview, and to become familiar with the user-interface.
The first official version of IUCLID 6 was published on 29 April 2016.
See also
*
European Chemicals Agency
The European Chemicals Agency (ECHA; ) is an agency of the European Union which manages the technical and administrative aspects of the implementation of the European Union regulation called Registration, Evaluation, Authorisation and Restricti ...
*
OECD
The Organisation for Economic Co-operation and Development (OECD; french: Organisation de coopération et de développement économiques, ''OCDE'') is an intergovernmental organisation with 38 member countries, founded in 1961 to stimulate e ...
*
European Commission
The European Commission (EC) is the executive of the European Union (EU). It operates as a cabinet government, with 27 members of the Commission (informally known as "Commissioners") headed by a President. It includes an administrative body o ...
*
REACH
*
Institute for Health and Consumer Protection
The Institute for Health and Consumer Protection or IHCP, located in Ispra, Italy, is one of the seven institutes of the Joint Research Centre (JRC), a Directorate-General of the European Commission (EC).
The Institute for Health and Consumer Prot ...
*
Joint Research Centre
The Joint Research Centre (JRC) is the European Commission's science and knowledge service which employs scientists to carry out research in order to provide independent scientific advice and support to European Union (EU) policy. The JRC is ...
References
External links
IUCLID 5 websiteIUCLID 6 websiteEuropean Chemicals AgencyInstitute for Health and Consumer Protection On-LineJoint Research Centre On-Line{{Webarchive, url=https://web.archive.org/web/20070119194131/http://www.jrc.ec.europa.eu/ , date=2007-01-19
REACH Legislation Full textThe REACH CD-ROM, a practical guide for REACHREACH Services Overview & Official REACH Texts eChemPortal a global portal to information on Chemical Substances
Data entry accelerator for IUCLID
Cheminformatics
Government databases of the European Union
Java platform software
Regulation of chemicals in the European Union