Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''ITK''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
ITK is a member of the
TEC family of
kinases and is highly expressed in
T cell
A T cell is a type of lymphocyte. T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response. T cells can be distinguished from other lymphocytes by the presence of a T-cell r ...
s.
Function
This gene encodes an intracellular
tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to the tyrosine residues of specific proteins inside a cell. It functions as an "on" or "off" switch in many cellular functions.
Tyrosine kinases belong to a larger cla ...
expressed in T-cells. The protein is thought to play a role in T-cell
proliferation and
differentiation.
ITK is functionally important for the development and effector function of
Th2 and
Th17 cells.
Mice lacking ITK were shown to not be susceptible to asthma.
Structure
This protein contains the following
domains, which are often found in intracellular kinases:
*
N-terminus –
PH (pleckstrin homology domain)
* TH – Tec family homology domain (including
Bruton's tyrosine kinase Cys-rich motif and Proline rich region)
*
SH3 – (Src homology 3)
*
SH2 – (Src homology 2)
*
C-terminus – tyrosine kinase, catalytic domain
Interactions
ITK (gene) has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
FYN
Funen ( da, Fyn, ), with an area of , is the third-largest island of Denmark, after Zealand and Vendsyssel-Thy. It is the 165th-largest island in the world. It is located in the central part of the country and has a population of 469,947 as ...
,
*
Grb2[ and
* ]KHDRBS1
KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the ''KHDRBS1'' gene.
This gene encodes a member of the K homology domain-containing, RNA-binding, signal transduction-associate ...
,KPNA2
Importin subunit alpha-1 is a protein that in humans is encoded by the ''KPNA2'' gene.
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear ...
,LAT
Lat or LAT may refer to:
Places
* Lat, Fuman, village in Gilan Province, Iran
* Lat, Rasht, village in Gilan Province, Iran
* Lat, Mazandaran, village in Iran
* Lat-e Disar, village in Mazandaran Province, Iran
* Lat, Qazvin, village in I ...
,PLCG1
Phospholipase C, gamma 1, also known as PLCG1,is a protein that in humans involved in cell growth, migration, apoptosis, and proliferation. It is encoded by the ''PLCG1'' gene and is part of the PLC superfamily.
Function
PLCγ1 is a cell grow ...
,PPIA
Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the ''PPIA'' gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein ca ...
,WAS
Was or WAS may refer to:
* ''Was'', a past-tense form of the English copular verb ''to be''
People
* David Was (born c. 1952), the stage name of multi-instrumentalist and songwriter David Weiss
* Don Was (born 1952), the stage name of bass guita ...
.
References
Further reading
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Tyrosine kinases