Integrin alpha-3 is a
protein that in humans is encoded by the ''ITGA3''
gene.
ITGA3 is an
integrin alpha subunit. Together with
beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and
corticogenesis
Corticogenesis is the process during which the cerebral cortex of the brain is formed as part of the development of the nervous system of mammals including development of the nervous system in humans, its development in humans. The cortex is the ou ...
, acted upon by such factors as
netrin-1
Netrin-1 is a protein that in humans is encoded by the ''NTN1'' gene.
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon gui ...
and
reelin
Reelin, encoded by the ''RELN'' gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this import ...
.
ITGA3 encodes the
integrin alpha 3 chain. Integrins are hetero
dimer
Dimer may refer to:
* Dimer (chemistry), a chemical structure formed from two similar sub-units
** Protein dimer, a protein quaternary structure
** d-dimer
* Dimer model, an item in statistical mechanics, based on ''domino tiling''
* Julius Dimer ( ...
ic integral membrane
proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield
disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many
extracellular matrix proteins.
Alternative names
The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').
Interactions
CD49c has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CD9
*
FHL2,
*
LGALS8,
and
*
TSPAN4.
References
Further reading
*
*
External links
*
ITGA3Info with links in th
Cell Migration Gateway
*
Integrins
Clusters of differentiation
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