Interstate 70S may refer to:
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Interstate 70S (Maryland)
Interstate 270 (I-270) is a auxiliary Interstate Highway in the U.S. state of Maryland that travels from I-495 (Capital Beltway) just north of Bethesda in Montgomery County north to I-70 in the city of Frederick in Frederick County. ...
, a former Interstate highway in Maryland, now numbered as Interstate 270
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Interstate 70S (Pennsylvania), a former Interstate highway in Pennsylvania
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