Human Brain Development Timeline
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Conception

Studies report that three primary structures are formed in the sixth gestational week. These are the
forebrain In the anatomy of the brain of vertebrates, the forebrain or prosencephalon is the Anatomical terms of location#Directional terms, rostral (forward-most) portion of the brain. The forebrain (prosencephalon), the midbrain (mesencephalon), and hin ...
, the
midbrain The midbrain or mesencephalon is the forward-most portion of the brainstem and is associated with vision, hearing, motor control, sleep and wakefulness, arousal (alertness), and temperature regulation. The name comes from the Greek ''mesos'', " ...
, and the
hindbrain The hindbrain or rhombencephalon or lower brain is a developmental categorization of portions of the central nervous system in vertebrates. It includes the medulla, pons, and cerebellum. Together they support vital bodily processes. Metencephalo ...
, also known as the prosencephalon, mesencephalon, and the rhombencephalon respectively. Five secondary structures originate from these in the seventh gestational week. These are the
telencephalon The cerebrum, telencephalon or endbrain is the largest part of the brain containing the cerebral cortex (of the two cerebral hemispheres), as well as several subcortical structures, including the hippocampus, basal ganglia, and olfactory bulb. In ...
,
diencephalon The diencephalon (or interbrain) is a division of the forebrain (embryonic ''prosencephalon''). It is situated between the telencephalon and the midbrain (embryonic ''mesencephalon''). The diencephalon has also been known as the 'tweenbrain in ol ...
,
mesencephalon The midbrain or mesencephalon is the forward-most portion of the brainstem and is associated with vision, hearing, motor control, sleep and wakefulness, arousal (alertness), and temperature regulation. The name comes from the Greek ''mesos'', "m ...
,
metencephalon The metencephalon is the embryonic part of the hindbrain that differentiates into the pons and the cerebellum. It contains a portion of the fourth ventricle and the trigeminal nerve (CN V), abducens nerve (CN VI), facial nerve (CN VII), and a port ...
, and
myelencephalon The myelencephalon or afterbrain is the most posterior region of the embryonic hindbrain, from which the medulla oblongata develops. Development Neural tube to myelencephalon During fetal development, divisions of the neural tube that give ...
; the
lateral ventricles The lateral ventricles are the two largest ventricles of the brain and contain cerebrospinal fluid (CSF). Each cerebral hemisphere contains a lateral ventricle, known as the left or right ventricle, respectively. Each lateral ventricle resemble ...
,
third ventricles The third ventricle is one of the four connected ventricles of the ventricular system within the mammalian brain. It is a slit-like cavity formed in the diencephalon between the two thalami, in the midline between the right and left lateral ve ...
,
cerebral aqueduct The cerebral aqueduct (aqueductus mesencephali, mesencephalic duct, sylvian aqueduct or aqueduct of Sylvius) is a conduit for cerebrospinal fluid (CSF) that connects the third ventricle to the fourth ventricle of the ventricular system of the brai ...
, and upper and lower parts of the
fourth ventricle The fourth ventricle is one of the four connected fluid-filled cavities within the human brain. These cavities, known collectively as the ventricular system, consist of the left and right lateral ventricles, the third ventricle, and the fourth ve ...
in adulthood originated from these structures. The appearance of cortical folds first takes place during 24 and 32 weeks of
gestation Gestation is the period of development during the carrying of an embryo, and later fetus, inside viviparous animals (the embryo develops within the parent). It is typical for mammals, but also occurs for some non-mammals. Mammals during pregna ...
.


Childhood and adolescence

Cortical
white matter White matter refers to areas of the central nervous system (CNS) that are mainly made up of myelinated axons, also called tracts. Long thought to be passive tissue, white matter affects learning and brain functions, modulating the distribution ...
increases from childhood (~9 years) to adolescence (~14 years), most notably in the frontal and parietal cortices. Cortical
grey matter Grey matter is a major component of the central nervous system, consisting of neuronal cell bodies, neuropil (dendrites and unmyelinated axons), glial cells (astrocytes and oligodendrocytes), synapses, and capillaries. Grey matter is distingui ...
development peaks at ~12 years of age in the frontal and parietal cortices, and 14–16 years in the temporal lobes (with the superior temporal cortex being last to mature), peaking at about roughly the same age in both sexes according to reliable data. In terms of grey matter loss, the sensory and motor regions mature first, followed by other cortical regions. Human brain maturation continues to around 20 to 25 and even up to 30 years of age and beyond. Although it is worth noting that there is no actual evidence suggesting that impulse control only finishes developing in humans in the twenties. It is a common misconception that the brain only fully develops by 25, as the number comes from two particular studies, one on psychosocial maturity, where greater than 50% of people being tested only reached a plateau in impulse control by the age of 25. However, some people were recorded to have reached adult-levels by mid-teens, and some had not reached it even after 30. It is worth noting that the majority of countries showed that people's impulse control linearly improved with age, suggested that most cutoffs are somewhat arbitrary. It is also believed to have originated from a study by Jay Giedd based on MRI data, scanning the brains of people aged up to 21 or 25 years and no participants that were older. Years of research and testing seem to indicate that the brain is functioning in full adult capacity by the time youths reach high school, or roughly the age range of 14-16. Though it is a controversial psychometric, adult IQ also begins to be tested around this age range, with the Raven Progressive Metrices test beginning at age 14 and Wechsler Adult IQ test beginning at age 16 (though scores between 14 and 16 on the Weschler test have differences so small that they are considered unreliable). This may bring into question the effectiveness of brain development studies in treating and successfully rehabilitating criminal youth.


See also

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Brain development timelines These are timelines of brain development events in different animal species. *Mouse brain development timeline * Macaque brain development timeline *Human brain development timeline See also * Encephalization quotient * Evolution of the brain * N ...
*
Development of the nervous system in humans The development of the nervous system in humans, or neural development or neurodevelopment involves the studies of embryology, developmental biology, and neuroscience to describe the cellular and molecular mechanisms by which the complex nervous ...
*
Evolution of the brain There is much to be discovered about the evolution of the brain and the principles that govern it. While much has been discovered, not everything currently known is well understood. The evolution of the brain has appeared to exhibit diverging ada ...
*
Practopoiesis An adaptive system is a set of interacting or interdependent entities, real or abstract, forming an integrated whole that together are able to respond to environmental changes or changes in the interacting parts, in a way analogous to either conti ...


References

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External links


Translating Time
— a website providing translation of brain developmental times among different species Embryology of nervous system Developmental neuroscience