Haplogroup R0 (formerly known as haplogroup pre-HV) is a

human mitochondrial DNA Human mitochondrial genetics is the study of the genetics of human mitochondrial DNA (the DNA contained in human mitochondria). The human mitochondrial genome is the entirety of hereditary information contained in human mitochondria. Mitochondri ...

(mtDNA) haplogroup.

Origin

Haplogroup R0 derives from the macro-haplogroup R. It is an ancestral clade to the R0a subclade and haplogroup HV, and is therefore antecedent to the haplogroups H and V. R0's greater subclade variety in the

Arabian Peninsula The Arabian Peninsula, (; ar, شِبْهُ الْجَزِيرَةِ الْعَرَبِيَّة, , "Arabian Peninsula" or , , "Island of the Arabs") or Arabia, is a peninsula of Western Asia, situated northeast of Africa on the Arabian Plate ...

suggests that the clade originated in and spread from there. R0a is believed to have evolved in

Ice Age An ice age is a long period of reduction in the temperature of Earth's surface and atmosphere, resulting in the presence or expansion of continental and polar ice sheets and alpine glaciers. Earth's climate alternates between ice ages and gree ...

oases in

South Arabia South Arabia () is a historical region that consists of the southern region of the Arabian Peninsula in Western Asia, mainly centered in what is now the Republic of Yemen, yet it has also historically included Najran, Jizan, Al-Bahah, and 'Asi ...

around 22,000 years ago. The subclade would then have spread from there with the onset of the Late Glacial period circa 15,000 ybp.

Distribution

Haplogroup R0 has been found in around 55% of osteological remains belonging to the

Eneolithic The asterisk ( ), from Late Latin , from Ancient Greek , ''asteriskos'', "little star", is a typographical symbol. It is so called because it resembles a conventional image of a heraldic star. Computer scientists and mathematicians often voc ...

Trypillia Trypillia ( ua , Трипiлля) is a selo in Obukhiv Raion (district) of Kyiv Oblast in central Ukraine, with 2,800 inhabitants (as of 1 January 2005). It belongs to Ukrainka urban hromada, one of the hromadas of Ukraine. Trypillia lies abou ...

culture. The R0 clade has also been found among

Iberomaurusian The Iberomaurusian is a backed bladelet lithic industry found near the coasts of Morocco, Algeria, and Tunisia. It is also known from a single major site in Libya, the Haua Fteah, where the industry is locally known as the Eastern Oranian.The " ...

specimens at the

Taforalt Taforalt or Grotte des Pigeons is a cave in the province of Berkane, Aït Iznasen region, Morocco, possibly the oldest cemetery in North Africa (Humphrey ''et al.'' 2012). It contained at least 34 Iberomaurusian adolescent and adult human skele ...

and Afalou prehistoric sites, which date from the

Epipaleolithic In archaeology, the Epipalaeolithic or Epipaleolithic (sometimes Epi-paleolithic etc.) is a period occurring between the Upper Paleolithic and Neolithic during the Stone Age. Mesolithic also falls between these two periods, and the two are someti ...

. Among the Taforalt individuals, around 17% of the observed haplotypes belonged to various R0 subclades, including R0a1a (3/24; 13%) and R0a2c (1/24; 4%). Among the Afalou individuals, one R0a1a haplotype was detected (1/9; 11%). R0 has likewise been observed among mummies excavated at the Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-

Ptolemaic Ptolemaic is the adjective formed from the name Ptolemy, and may refer to: Pertaining to the Ptolemaic dynasty * Ptolemaic dynasty, the Macedonian Greek dynasty that ruled Egypt founded in 305 BC by Ptolemy I Soter * Ptolemaic Kingdom Pertaining ...

/late

New Kingdom New is an adjective referring to something recently made, discovered, or created. New or NEW may refer to: Music * New, singer of K-pop group The Boyz Albums and EPs * ''New'' (album), by Paul McCartney, 2013 * ''New'' (EP), by Regurgitator, ...

, Ptolemaic, and

Roman Roman or Romans most often refers to: *Rome, the capital city of Italy *Ancient Rome, Roman civilization from 8th century BC to 5th century AD *Roman people, the people of ancient Rome *''Epistle to the Romans'', shortened to ''Romans'', a letter ...

periods. The 3rd century AD

Catholic Church The Catholic Church, also known as the Roman Catholic Church, is the largest Christian church, with 1.3 billion baptized Catholics worldwide . It is among the world's oldest and largest international institutions, and has played a ...

Saint, Fortunato of

Serracapriola Serracapriola ('Særræchæprióle' or simply 'a Særre' in the local '' apulo-molisana speech'') is an Italian town of 4.039 inhabitants, located in the province of Foggia, Apulia. It is part of the Gargano National Park, and it is p ...

, was also found to carry the R0a'b subclade. R0 today occurs commonly in the Arabian peninsula, with its highest frequency observed nearby among the Soqotri (40.7%). The Soqotri also have the greatest R0 subclade diversity. The clade is likewise found at high frequencies among the Kalash in

South Asia South Asia is the southern subregion of Asia, which is defined in both geographical and ethno-cultural terms. The region consists of the countries of Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka.;;;;;;;; ...

(23%). Additionally, moderate frequencies of R0 occur in

Northeast Africa Northeast Africa, or ''Northeastern Africa'' or Northern East Africa as it was known in the past, is a geographic regional term used to refer to the countries of Africa situated in and around the Red Sea. The region is intermediate between North ...

Anatolia Anatolia, tr, Anadolu Yarımadası), and the Anatolian plateau, also known as Asia Minor, is a large peninsula in Western Asia and the westernmost protrusion of the Asian continent. It constitutes the major part of modern-day Turkey. The re ...

, the

Iranian Plateau The Iranian plateau or Persian plateau is a geological feature in Western Asia, Central Asia, and South Asia. It comprises part of the Eurasian Plate and is wedged between the Arabian Plate and the Indian Plate; situated between the Zagros ...

and

Dalmatia Dalmatia (; hr, Dalmacija ; it, Dalmazia; see #Name, names in other languages) is one of the four historical region, historical regions of Croatia, alongside Croatia proper, Slavonia, and Istria. Dalmatia is a narrow belt of the east shore of ...

. The haplogroup has been observed among Chad Arabs (19%), Sudanese Copts (13.8%), Tigrais (13.6%),

Somalis The Somalis ( so, Soomaalida 𐒈𐒝𐒑𐒛𐒐𐒘𐒆𐒖, ar, صوماليون) are an ethnic group native to the Horn of Africa who share a common ancestry, culture and history. The Lowland East Cushitic Somali language is the shared ...

(13.3%),

Oromos The Oromo (pron. Oromo: ''Oromoo'') are a Cushitic ethnic group native to the Oromia region of Ethiopia and parts of Northern Kenya, who speak the Oromo language (also called ''Afaan Oromoo'' or ''Oromiffa''), which is part of the Cushitic br ...

(13.3%), Afar (12.5%), Amhara (11.5%),

Gurage The Gurage (, Gurage: ጉራጌ) are a Semitic-speaking ethnic group inhabiting Ethiopia.G. W. E. Huntingford, "William A. Shack: The Gurage: a people of the ensete culture" They inhabit the Gurage Zone, a fertile, semi-mountainous region in ce ...

(10%), Reguibate Sahrawi (9.26%; 0.93% R0a and 8.33% R0a1a),
S5 Table
/ref> Gaalien (9%), Beja (8.3%),

Nubians Nubians () (Nobiin: ''Nobī,'' ) are an ethnic group indigenous to the region which is now northern Sudan and southern Egypt. They originate from the early inhabitants of the central Nile valley, believed to be one of the earliest cradles of c ...

(8%), Arakien (5.9%),

Yemen Yemen (; ar, ٱلْيَمَن, al-Yaman), officially the Republic of Yemen,, ) is a country in Western Asia. It is situated on the southern end of the Arabian Peninsula, and borders Saudi Arabia to the Saudi Arabia–Yemen border, north and ...

is (5.1–27.7%),

Iraqis Iraqis ( ar, العراقيون, ku, گه‌لی عیراق, gelê Iraqê) are people who originate from the country of Iraq. Iraq consists largely of most of ancient Mesopotamia, the native land of the indigenous Sumerian, Akkadian, Assyrian, ...

(4.8%),

Druze The Druze (; ar, دَرْزِيٌّ, ' or ', , ') are an Arabic-speaking esoteric ethnoreligious group from Western Asia who adhere to the Druze faith, an Abrahamic, monotheistic, syncretic, and ethnic religion based on the teachings of ...

(4.3%),

Palestinians Palestinians ( ar, الفلسطينيون, ; he, פָלַסְטִינִים, ) or Palestinian people ( ar, الشعب الفلسطيني, label=none, ), also referred to as Palestinian Arabs ( ar, الفلسطينيين العرب, label=non ...

(4%),

Algeria ) , image_map = Algeria (centered orthographic projection).svg , map_caption = , image_map2 = , capital = Algiers , coordinates = , largest_city = capital , relig ...

ns (1.67%), and

Saudis Saudis ( ar, سعوديون, Suʿūdiyyūn) are people identified with the country of Saudi Arabia. This connection may be residential, legal, historical or cultural. The Saudis are composed mainly of Arabs and primarily speak a regional dialect ...

(0–25%).

Subclades

Tree

Spatial frequency distribution maps of mtDNA haplogroup R0a

This phylogenetic tree of haplogroup R0 subclades is based on the paper by Mannis van Oven and Manfred Kayser ''Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation'' and subsequent published research. *R **R0 (or pre-HV) ***R0a (or (pre-HV)1) ****R0a1 or (pre-HV)1a *****R0a1a ****60.1T *****R0a2 or (pre-HV)1b ******R0a2a ******R0a2b ******R0a2c ******R0a2d ******R0a2e **** HV *****HV0 *****HV1 *****73 *****HV4 *****HV5 ***** H

References

{{Reflist, 2

External links

*General **Ian Logan'
Mitochondrial DNA Site
**Mannis van Oven'
PhyloTree
*Haplogroup R0

from ''

National Geographic ''National Geographic'' (formerly the ''National Geographic Magazine'', sometimes branded as NAT GEO) is a popular American monthly magazine published by National Geographic Partners. Known for its photojournalism, it is one of the most widely ...