The hypothalamospinal tract arises mainly from the paraventricular nucleus, lateral and posterior hypothalamic areas. This tract descends through the periaqueductal gray and adjacent reticular formation. The hypothalamospinal tract also connects the hypothalamus to the

ciliospinal center The ciliospinal center (in Latin: ''centrum ciliospinale'') is a structure which receives input from the pretectum, and has output to the superior cervical ganglion. It is located in the intermediolateral cell columns (IMLCC) of the spinal cord ...

of the intermediolateral cell column in the spinal cord (T1 to L2). It is found in the dorsolateral quadrant of the lateral funiculus, in the lateral tegmentum of the medulla, pons and midbrain. Lesions of the hypothalamospinal tract cause ipsilateral

Horner's syndrome Horner's syndrome, also known as oculosympathetic paresis, is a combination of symptoms that arises when a group of nerves known as the sympathetic trunk is damaged. The signs and symptoms occur on the same side (ipsilateral) as it is a lesion o ...

.James D. Fix. High-Yield Neuroanatomy 4th Edition. Wolters Kluwer, Lippincott Williams and Wilkins. pp. 63-64. Lesions of the

posterior inferior cerebellar artery The posterior inferior cerebellar artery (PICA) is the largest branch of the vertebral artery. It is one of the three main arteries that supply blood to the cerebellum, a part of the brain. Blockage of the posterior inferior cerebellar artery can r ...

(PICA) or the vertebral artery can lead to lateral medullary syndrome, with ipsilateral

Horner's Syndrome Horner's syndrome, also known as oculosympathetic paresis, is a combination of symptoms that arises when a group of nerves known as the sympathetic trunk is damaged. The signs and symptoms occur on the same side (ipsilateral) as it is a lesion o ...

as the result of lesioning this nucleus.

References

{{Authority control Hypothalamus Brainstem Central nervous system pathways