HrrF RNA (''Haemophilus'' regulatory RNA responsive to iron Fe) is a small

non-coding RNA A non-coding RNA (ncRNA) is a functional RNA molecule that is not translated into a protein. The DNA sequence from which a functional non-coding RNA is transcribed is often called an RNA gene. Abundant and functionally important types of non-c ...

involved in iron homeostasis in ''

Haemophilus ''Haemophilus'' is a genus of Gram-negative, pleomorphic, coccobacilli bacteria belonging to the family Pasteurellaceae. While ''Haemophilus'' bacteria are typically small coccobacilli, they are categorized as pleomorphic bacteria because of ...

'' species. Orthologues exist only among other '' Pasteurellacae.'' Iron- regulated sRNAs JA01- JA04 were identified in related ''Aggregatibacte''r. It is an analog to PrrF and

RyhB RyhB RNA is a 90 nucleotide RNA that down-regulates a set of iron-storage and iron-using proteins when iron is limiting; it is itself negatively regulated by the ferric uptake repressor protein, Fur ( Ferric uptake regulator). Discovery The gene ...

RNAs. HrrF is maximally expressed when iron levels are low. Ferric uptake regulator (Fur) binds upstream of the ''hrrF'' promoter. HrrF stability is not dependent on the RNA chaperone

Hfq The Hfq protein (also known as HF-I protein) encoded by the ''hfq'' gene was discovered in 1968 as an ''Escherichia coli'' host factor that was essential for replication of the bacteriophage Qβ. It is now clear that Hfq is an abundant bacterial RN ...

. RNA-seq has shown that HrrF targets are mRNAs of genes whose products are involved in

molybdate In chemistry a molybdate is a compound containing an oxoanion with molybdenum in its highest oxidation state of 6. Molybdenum can form a very large range of such oxoanions which can be discrete structures or polymeric extended structures, althou ...

uptake, deoxyribonucleotide synthesis, and amino acid synthesis.

References

Non-coding RNA {{molecular-cell-biology-stub

See also

References