Howard Lincoln Fields (born 1939) is an American neuroscientist and clinical neurologist with expertise in pain and in opioid pharmacology. He is currently professor of neurology and physiology emeritus at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...

(UCSF).

Biography

Born in Chicago, Illinois, in 1939, Fields studied physiology at the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

(BS 1960). In 1965–1966, he received an MD and PhD in

neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, development ...

from Stanford University. He was a graduate student of

Donald Kennedy Donald Kennedy (August 18, 1931 – April 21, 2020) was an American scientist, public administrator, and academic. He served as Commissioner of the U.S. Food and Drug Administration (1977–1979), President of Stanford University (1980– ...

, future President of Stanford University. He also holds the distinction of being the first person ever awarded a Neuroscience PhD from Stanford. He did a medical internship at

Bellevue Hospital Bellevue Hospital (officially NYC Health + Hospitals/Bellevue and formerly known as Bellevue Hospital Center) is a hospital in New York City and the oldest public hospital in the United States. One of the largest hospitals in the United States b ...

in New York, then spent three years (1967-1970) as a research

neurologist Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal c ...

at Walter Reed Army Institute of Research. From 1970-1972, Fields trained at the Harvard neurology program at

Boston City Hospital The Boston City Hospital (1864–1996), in Boston, Massachusetts, was a public hospital, located in the South End. It was "intended for the use and comfort of poor patients, to whom medical care will be provided at the expense of the city, and . ...

, in Massachusetts. He then joined the faculty of the Neurology and Physiology Departments at the University of California San Francisco where he collaborated with other neuroscientists including

Jon Levine The Philosopher Kings are a Canadian band. The band was most commercially successful in the late 1990s and have been nominated for five Juno Awards, winning one in 1996 for "Best New Group". Most of the band members, current and former, have also ...

and Allan Basbaum.

Research

His research on the nervous system has ranged from pain, opioid pharmacology and substance abuse to

endogenous Endogenous substances and processes are those that originate from within a living system such as an organism, tissue, or cell. In contrast, exogenous substances and processes are those that originate from outside of an organism. For example, es ...

opioids in pain relief and reward. Fields was one of the

UCSF The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It condu ...

pain management center founders. With his UCSF colleagues, Fields has made major contributions to understanding the neurobiology of pain, opioid analgesia and opioid reward, and to the mechanistic understanding and treatment of neuropathic pain. His group with Allan Basbaum described a top-down pain modulating circuit that mediates opioid analgesia and exerts bidirectional control of pain. His group was the first to establish the clinical effectiveness of opioids for neuropathic pain. They also discovered that topical

lidocaine Lidocaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia. When used for local anaesthesia or in nerve blocks, lidoca ...

was effective to reduce the pain of post- herpetic

neuralgia Neuralgia (Greek ''neuron'', "nerve" + ''algos'', "pain") is pain in the distribution of one or more nerves, as in intercostal neuralgia, trigeminal neuralgia, and glossopharyngeal neuralgia. Classification Under the general heading of neuralg ...

. In other discoveries, Fields with Jon Levine discovered that placebo analgesia was mediated by endogenous opioids by demonstrating that it is blocked by the opioid antagonist naloxone. Later work by Fields and his colleagues led to the discovery of neural mechanisms in the midbrain and

striatum The striatum, or corpus striatum (also called the striate nucleus), is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain. The striatum is a critical component of the motor and reward systems; receives glutamate ...

that contribute to opioid reward. Fields’ specialties include neurology,

neuropharmacology Neuropharmacology is the study of how drugs affect function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmac ...

and neuroscience.

Awards and honors

* 1997 Elected to

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

* 2000 Cotzias Lecture

American Academy of Neurology The American Academy of Neurology (AAN) is a professional society representing over 38,000 neurologists and neuroscientists. As a medical specialty society it was established in 1948 by A.B. Baker of the University of Minnesota to advance the ar ...

* 2006 Raymond D. Adams Lecture

American Neurological Association The American Neurological Association (ANA) is a professional society of academic neurologists and neuroscientists devoted to advancing the goals of academic neurology; to training and educating neurologists and other physicians in the neurologic ...

* 2010 Elected to

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

* 2012 Mitchell Max Award for Neuropathic Pain Research

Publications

* ''Clinical and neuroscience evidence supports the critical importance of patient expectations and agency in opioid tapering.'' Pain. 2021 Aug 09. Darnall BD, Fields HL. PMID 34382602. * ''Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.'' Nat Neurosci. 2021 Aug 09. Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S. PMID 34373644. * ''Onset hyperalgesia and offset analgesia: Transient increases or decreases of noxious thermal stimulus intensity robustly modulate subsequent perceived pain intensity.'' PLoS One. 2020; 15(12):e0231124. Alter BJ, Aung MS, Strigo IA, Fields HL. PMID 33290407. * ''A Midbrain Circuit that Mediates Headache Aversiveness in Rats.'' Cell Rep. 2019 09 10; 28(11):2739-2747.e4. Waung MW, Margolis EB, Charbit AR, Fields HL. PMID 31509737. * ''How expectations influence pain.'' Pain. 2018 Sep; 159 Suppl 1:S3-S10. Fields HL. PMID 30113941. * ''Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor.'' Neuropharmacology. 2017 Sep 01; 123:420-432. Margolis EB, Fujita W, Devi LA, Fields HL. PMID 28645621. * ''Cortico-Accumbens Regulation of Approach-Avoidance Behavior Is Modified by Experience and Chronic Pain.'' Cell Rep. 2017 05 23; 19(8):1522-1531. Schwartz N, Miller C, Fields HL. PMID 28538173. * ''Mu Opioid Receptor Actions in the Lateral Habenula.'' PLoS One. 2016; 11(7):e0159097. Margolis EB, Fields HL. PMID 27427945. * ''Ventral Pallidum Neurons Encode Incentive Value and Promote Cue-Elicited Instrumental Actions''. Neuron. 2016 06 15; 90(6):1165-1173. Richard JM, Ambroggi F, Janak PH, Fields HL. PMID 27238868. * ''Mu-opioid receptor activation in the medial shell of nucleus accumbens promotes alcohol consumption, self-administration and cue-induced reinstatement.'' Neuropharmacology. 2016 09; 108:14-23. Richard JM, Fields HL. PMID 27089981. * ''Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons''. Pain. 2016 Jan; 157(1):166-173. Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. PMID 26335909. * ''Endogenous opioid activity in the anterior cingulate cortex is required for relief of pain.'' J Neurosci. 2015 May 6; 35(18):7264-71. Navratilova E, Xie JY, Meske D, Qu C, Morimura K, Okun A, Arakawa N, Ossipov M, Fields HL, Porreca F. PMID 25948274. * ''Understanding opioid reward.'' Trends Neurosci. 2015 Apr; 38(4):217-25. Fields HL, Margolis EB. PMID 25637939. * ''Direct bidirectional μ-opioid control of midbrain dopamine neurons.'' J Neurosci. 2014 Oct 29; 34(44):14707-16. Margolis EB, Hjelmstad GO, Fujita W, Fields HL. PMID 25355223. * ''Neuroscience. More pain; less gain.'' Science. 2014 Aug 01; 345(6196):513-4. Fields HL. PMID 25082685. * ''Parceling human accumbens into putative core and shell dissociates encoding of values for reward and pain.'' J Neurosci. 2013 Oct 09; 33(41):16383-93. Baliki MN, Mansour A, Baria AT, Huang L, Berger SE, Fields HL, Apkarian AV. PMID 24107968. * ''Capturing the aversive state of cephalic pain preclinically.'' Ann Neurol. 2013 Aug; 74(2):257-65. De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F. PMID 23686557. * ''Intra-VTA deltorphin, but not DPDPE, induces place preference in ethanol-drinking rats: distinct DOR-1 and DOR-2 mechanisms control ethanol consumption and reward.'' Alcohol Clin Exp Res. 2014 Jan; 38(1):195-203. Mitchell JM, Margolis EB, Coker AR, Allen DC, Fields HL. PMID 24033469. * ''Catechol-O-methyltransferase genotype modulates opioid release in decision circuitry.'' Clin Transl Sci. 2013 Oct; 6(5):400-3. Mitchell JM, O'Neil JP, Jagust WJ, Fields HL. PMID 24127930. * ''Opioid modulation of ventral pallidal afferents to ventral tegmental area neurons.'' J Neurosci. 2013 Apr 10; 33(15):6454-9. Hjelmstad GO, Xia Y, Margolis EB, Fields HL. PMID 23575843.

References

External links

USCF profile

PubMed
{{DEFAULTSORT:Fields, Howard 1939 births Living people Members of the National Academy of Medicine American neuroscientists American neurologists