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Entheogenic drugs Entheogens are psychoactive substances that induce alterations in perception, mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclopedia of Psychoact ...
have been used by various groups for thousands of years. There are numerous historical reports as well as modern, contemporary reports of indigenous groups using
entheogen Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...
s,
chemical substance A chemical substance is a form of matter having constant chemical composition and characteristic properties. Some references add that chemical substance cannot be separated into its constituent elements by physical separation methods, i.e., wi ...
s used in a
religious Religion is usually defined as a social system, social-cultural system of designated religious behaviour, behaviors and practices, morality, morals, beliefs, worldviews, religious text, texts, sacred site, sanctified places, prophecy, prophecie ...
,
shamanic Shamanism is a religious practice that involves a practitioner (shaman) interacting with what they believe to be a spirit world through altered states of consciousness, such as trance. The goal of this is usually to direct spirits or spiritu ...
, or spiritual context.


Early history

One of the oldest known entheogens is peyote, which has been used for at least 5,700 years by Native Americans in Mexico.


20th century

In 1912
Merck Merck refers primarily to the German Merck family and three companies founded by the family, including: * the Merck Group, a German chemical, pharmaceutical and life sciences company founded in 1668 ** Merck Serono (known as EMD Serono in the Unite ...
laboratories sintetized the drug 3,4-Methylenedioxymethamphetamine (MDMA), currently known as ecstasy, It was used to enhance
psychotherapy Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome pro ...
beginning in the 1970s and became popular as a street drug in the 1980s. In 1928
Heinrich Klüver Heinrich Klüver (; May 25, 1897 – February 8, 1979) was a German-American biological psychologist and philosopher born in Holstein. After having served in the Imperial German Army during World War I, he studied at both the University of Hambur ...
was the first to systematically study its psychological effects in a small book called Mescal and Mechanisms of Hallucinations. The book stated that the drug could be used to research the unconscious mind. He coined the term "cobweb figure" in the 1920s to describe one of the four form constant geometric visual hallucinations experienced in the early stage of a mescaline trip: "Colored threads running together in a revolving center, the whole similar to a cobweb". The other three are the chessboard design, tunnel, and spiral. Klüver wrote that "many 'atypical' visions are upon close inspection nothing but variations of these form-constants." In 1953
Aldous Huxley Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer and philosopher. He wrote nearly 50 books, both novels and non-fiction works, as well as wide-ranging essays, narratives, and poems. Born into the prominent Huxley ...
published ''
The Doors of Perception ''The Doors of Perception'' is an autobiographical book written by Aldous Huxley. Published in 1954, it elaborates on his psychedelic experience under the influence of mescaline in May 1953. Huxley recalls the insights he experienced, rangin ...
'', in it elaborates on his
psychedelic experience A psychedelic experience (known colloquially as a trip) is a temporary altered state of consciousness induced by the consumption of a psychedelic substance (most commonly LSD, mescaline, psilocybin mushrooms, or DMT). For example, an acid tr ...
under the influence of
mescaline Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sou ...
in May 1953. Huxley recalls the insights he experienced, ranging from the "purely aesthetic" to "sacramental vision".


MK Ultra

R. Gordon Wasson had a funded expedition in 1956 by the CIA's
MK-Ultra Project MKUltra (or MK-Ultra) was an illegal human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA), intended to develop procedures and identify drugs that could be used in interrogations to weak ...
subproject 58, as was revealed by documents obtained by John Marks under the
Freedom of Information Act Freedom of Information Act may refer to the following legislations in different jurisdictions which mandate the national government to disclose certain data to the general public upon request: * Freedom of Information Act 1982, the Australian act * ...
. The documents state that Wasson was an 'unwitting' participant in the project. The funding was provided under the cover name of the ''Geschickter Fund for Medical Research'' (credited by Wasson at the end of his subsequent ''
Life Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energ ...
'' piece about the expedition). On May 13, 1957, ''
Life Life is a quality that distinguishes matter that has biological processes, such as signaling and self-sustaining processes, from that which does not, and is defined by the capacity for growth, reaction to stimuli, metabolism, energ ...
'' magazine published an article titled "
Seeking the Magic Mushroom "Seeking the Magic Mushroom" is a 1957 photo essay by amateur mycologist Robert Gordon Wasson describing his experience taking psilocybin mushrooms in 1955 during a Mazatec ritual in Oaxaca, Mexico. Wasson was one of the first Westerners to parti ...
", which introduced
psychoactive A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. Th ...
mushrooms to a wide audience for the first time. Just a few days later a personal account by his wife about their research in Mexico was published in the magazine ''This Week.'', it was written by
R. Gordon Wasson Robert Gordon Wasson (September 22, 1898 – December 23, 1986) was an American author, ethnomycologist, and Vice President for Public Relations at J.P. Morgan & Co. In the course of work funded by the Central Intelligence Agency (CIA), Wasso ...
,
ethnomycologist Ethnomycology is the study of the historical uses and sociological impact of fungi and can be considered a subfield of ethnobotany or ethnobiology. Although in theory the term includes fungi used for such purposes as tinder, medicine (medicinal m ...
, and Vice President for Public Relations at J.P. Morgan & Co. about the use of
psilocybin mushrooms Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocybe'', ''Pan ...
in religious rites of the indigenous
Mazatec people The Mazatec are an indigenous people of Mexico who inhabit the Sierra Mazateca in the state of Oaxaca and some communities in the adjacent states of Puebla and Veracruz. Language family The Mazatecan languages are part of the Popolocan family wh ...
of Mexico. In 1957 Gastón Guzmán Huerta, a Mexican
mycologist Mycology is the branch of biology concerned with the study of fungus, fungi, including their genetics, genetic and biochemistry, biochemical properties, their Taxonomy (biology), taxonomy and ethnomycology, their use to humans, including as a so ...
and
anthropologist An anthropologist is a person engaged in the practice of anthropology. Anthropology is the study of aspects of humans within past and present societies. Social anthropology, cultural anthropology and philosophical anthropology study the norms and ...
, was invited by the
University of Mexico The National Autonomous University of Mexico ( es, Universidad Nacional Autónoma de México, UNAM) is a public research university in Mexico. It is consistently ranked as one of the best universities in Latin America, where it's also the bigges ...
to assist
Rolf Singer Rolf Singer (June 23, 1906 – January 18, 1994) was a Germany, German-born mycologist and one of the most important Taxonomy (biology), taxonomists of gilled mushrooms (agarics) in the 20th century. After receiving his Ph.D. at the University ...
, who would arrive to Mexico in 1958 to study the hallucinogenic mushroom genus ''
Psilocybe ''Psilocybe'' ( ) is a genus of gilled mushrooms, growing worldwide, in the family Hymenogastraceae. Most or nearly all species contain the psychedelic compounds psilocybin and psilocin. Taxonomy Taxonomic history A 2002 study of the mole ...
''. While they were in the
Huautla de Jiménez Huautla de Jimenez is a town and municipality in the Mexican state of Oaxaca. It is part of the Teotitlán District in the north of the Cañada Region. The name Huautla comes from the Náhuatl. The town is called "Tejao" (also Eagle's Nest) in ...
region, in their last day of the expeditions, they met
R. Gordon Wasson Robert Gordon Wasson (September 22, 1898 – December 23, 1986) was an American author, ethnomycologist, and Vice President for Public Relations at J.P. Morgan & Co. In the course of work funded by the Central Intelligence Agency (CIA), Wasso ...
. Guzman became an authority on the genus ''Psilocybe''. In 1958, the French mycologist
Roger Heim Roger Heim (February 12, 1900 – September 17, 1979) was a French botanist specialising in mycology and tropical phytopathology. He was known for his studies describing the anatomy of the mushroom hymenium, the systematics and phylogeny of high ...
brought psilocybin tablets to
Mazatec The Mazatec are an indigenous people of Mexico who inhabit the Sierra Mazateca in the state of Oaxaca and some communities in the adjacent states of Puebla and Veracruz. Language family The Mazatecan languages are part of the Popolocan family wh ...
curandera A ''curandero'' (, healer; f. , also spelled , , f. ) is a traditional native healer or shaman found primarily in Latin America and also in the United States. A curandero is a specialist in traditional medicine whose practice can either contra ...
María Sabina María Sabina Magdalena García (22 July 1894 – 22 November 1985) was a Mazatec ''curandera'', shaman and poet who lived in Huautla de Jiménez, a town in the Sierra Mazateca area of the Mexican state of Oaxaca in southern Mexico."Sabina Rothen ...
, that was the first ''velada'' using the active principle of the mushrooms rather than the raw mushrooms themselves took place. In 1962, R. Gordon Wasson and Albert Hofmann went to Mexico to visit her. They also brought a bottle of psilocybin pills.
Sandoz Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...
was marketing them under the brand name Indocybin—"indo" for both Indian and
indole Indole is an aromatic heterocyclic organic compound with the formula C8 H7 N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environmen ...
(the nucleus of their chemical structures) and "cybin" for the main molecular constituent, psilocybin. Hofmann gave his synthesized
entheogen Entheogens are psychoactive substances that induce alterations in perception, mood (psychology), mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclop ...
to the ''curandera''. "Of course, Wasson recalled, Albert Hofmann is so conservative he always gives too little a dose, and it didn't have any effect." Hofmann had a different interpretation: "activation of the pills, which must dissolve in the stomach, takes place after 30 to 45 minutes. In contrast, the mushrooms when chewed, work faster as the drug is absorbed immediately". To settle her doubts about the pills, more were distributed. María, her daughter, and the shaman, Don Aurelio, ingested up to 30 mg each, a moderately high dose by current standards but not perhaps by the more experienced practitioners. At dawn, their Mazatec interpreter reported that María Sabina felt there was little difference between the pills and the mushrooms. She thanked Hofmann for the bottle of pills, saying that she would now be able to serve people even when no mushrooms were available.


Timothy Leary and Richard Alpert

Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from bold oracle to publicity hound. He was "a her ...
and
Richard Alpert Ram Dass (born Richard Alpert; April 6, 1931 – December 22, 2019), also known as Baba Ram Dass, was an American spiritual teacher, guru of modern yoga, psychologist, and author. His best-selling 1971 book '' Be Here Now'', which has been ...
studied and researched the effects of LSD and hallucinogenic mushrooms in the United States and Mexico.


Harvard psilocybin project

The
Harvard Psilocybin Project The Harvard Psilocybin Project was a series of experiments in psychology conducted by Timothy Leary and Richard Alpert. The founding board of the project consisted of Leary, Aldous Huxley, David McClelland (Leary's and Alpert's superior at Harvard ...
was a series of experiments in psychology conducted by
Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from bold oracle to publicity hound. He was "a her ...
and
Richard Alpert Ram Dass (born Richard Alpert; April 6, 1931 – December 22, 2019), also known as Baba Ram Dass, was an American spiritual teacher, guru of modern yoga, psychologist, and author. His best-selling 1971 book '' Be Here Now'', which has been ...
. The founding board of the project consisted of Leary,
Aldous Huxley Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer and philosopher. He wrote nearly 50 books, both novels and non-fiction works, as well as wide-ranging essays, narratives, and poems. Born into the prominent Huxley ...
,
David McClelland David Clarence McClelland (May 20, 1917 – March 27, 1998) was an American psychologist, noted for his work on motivation Need Theory. He published a number of works between the 1950s and the 1990s and developed new scoring systems for th ...
(Leary's and Alpert's superior at
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
), Frank Barron,
Ralph Metzner Ralph Metzner (May 18, 1936 – March 14, 2019) was a German-born American psychologist, writer and researcher, who participated in psychedelic research at Harvard University in the early 1960s with Timothy Leary and Richard Alpert (later named ...
, and two graduate students who were working on a project with
mescaline Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sou ...
. In 1960,
Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from bold oracle to publicity hound. He was "a her ...
and
Richard Alpert Ram Dass (born Richard Alpert; April 6, 1931 – December 22, 2019), also known as Baba Ram Dass, was an American spiritual teacher, guru of modern yoga, psychologist, and author. His best-selling 1971 book '' Be Here Now'', which has been ...
ordered psilocybin from Swiss-based company
Sandoz Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...
with the intent to test if different administration modes lead to different experiences. To a greater extent, they believed that psilocybin could be the solution for the emotional problems of the Western man.Andrew T. Weil
The Strange Case of the Harvard Drug Scandal
''Psychedelic-library.org'', 5 November 1963


Zihuatanejo Project

The
Zihuatanejo Project The Zihuatanejo Project was a psychedelic training center and intentional community created during the beginning of the counterculture of the 1960s by Timothy Leary and Richard Alpert under the umbrella of their nonprofit group, the International ...
was a psychedelic training center and
intentional community An intentional community is a voluntary residential community which is designed to have a high degree of social cohesion and teamwork from the start. The members of an intentional community typically hold a common social, political, religious, ...
created during the beginning of the
counterculture of the 1960s The counterculture of the 1960s was an anti-establishment cultural phenomenon that developed throughout much of the Western world in the 1960s and has been ongoing to the present day. The aggregate movement gained momentum as the civil rights mo ...
by
Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from bold oracle to publicity hound. He was "a her ...
and
Richard Alpert Ram Dass (born Richard Alpert; April 6, 1931 – December 22, 2019), also known as Baba Ram Dass, was an American spiritual teacher, guru of modern yoga, psychologist, and author. His best-selling 1971 book '' Be Here Now'', which has been ...
under the umbrella of their nonprofit group, the International Federation for Internal Freedom (IFIF). The community was located in
Zihuatanejo Zihuatanejo (), or Ixtapa-Zihuatanejo, is the fourth-largest city in the Mexican state of Guerrero. It was known by 18th century English mariners as Chequetan or Seguataneo. Politically the city belongs to the municipalities of Mexico, municipali ...
,
Guerrero Guerrero is one of the 32 states that comprise the 32 Federal Entities of Mexico. It is divided in 81 municipalities and its capital city is Chilpancingo and its largest city is Acapulcocopied from article, GuerreroAs of 2020, Guerrero the pop ...
,
Mexico Mexico (Spanish: México), officially the United Mexican States, is a country in the southern portion of North America. It is bordered to the north by the United States; to the south and west by the Pacific Ocean; to the southeast by Guatema ...
, and took up residence at the Hotel Catalina in the summers of 1962 and 1963.Leary, Timothy; Richard Alpert; Ralph Metzner. 1964. "Rationale of the Mexican Psychedelic Training Center". In Richard Blum: ''Utopiates: The Use and Users of LSD-25'', 178-186. New York: Atherton Press. Leary and Alpert first discovered the town of Zihuatanejo in 1960. After the
Marsh Chapel Experiment The Marsh Chapel Experiment, also called the "Good Friday Experiment", was a 1962 experiment conducted on Good Friday at Boston University's Marsh Chapel. Walter N. Pahnke, a graduate student in theology at Harvard Divinity School, designed the e ...
in 1962 they decided the area would make a good location for a training center.Conners, Peter. 2010. ''White Hand Society: The Psychedelic Partnership of Timothy Leary & Allen Ginsberg''. City Lights Books. The idea for the community was influenced by
Aldous Huxley Aldous Leonard Huxley (26 July 1894 – 22 November 1963) was an English writer and philosopher. He wrote nearly 50 books, both novels and non-fiction works, as well as wide-ranging essays, narratives, and poems. Born into the prominent Huxley ...
's fictional novel, ''
Island An island (or isle) is an isolated piece of habitat that is surrounded by a dramatically different habitat, such as water. Very small islands such as emergent land features on atolls can be called islets, skerries, cays or keys. An island ...
'' (1962).Lattin, Don. 2011. ''The Harvard Psychedelic Club: How Timothy Leary, Ram Dass, Huston Smith, and Andrew Weil Killed the Fifties and Ushered in a New Age for America''. HarperCollins. . 2011, 99, 112. Thousands of people applied to the IFIF in the hopes of joining the project in Zihuatanejo. Out of this pool of applicants, a small, select group of people were chosen. Amenities cost $200 a month per person, including food and lodging in bungalows near a secluded beach. Fishermen supplied a bounty of fresh fish from the bay. During the first training session in 1962, Leary and 35 guests rented the Catalina Hotel for a month using their own version of the ''
Tibetan Book of the Dead The ''Bardo Thodol'' (, "Liberation Through Hearing During the Intermediate State"), commonly known in the West as ''The Tibetan Book of the Dead'', is a terma text from a larger corpus of teachings, the ''Profound Dharma of Self-Liberation ...
'' as a guide book for
LSD Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, vi ...
sessions;
Ralph Metzner Ralph Metzner (May 18, 1936 – March 14, 2019) was a German-born American psychologist, writer and researcher, who participated in psychedelic research at Harvard University in the early 1960s with Timothy Leary and Richard Alpert (later named ...
and Richard Alpert helped manage the group. Group LSD sessions began in the morning with the consumption of liquid LSD, with a dosage of 100 to 500 micrograms ingested by participating individuals; the experience would usually last until late afternoon.


Concord Prison Experiment

The
Concord Prison Experiment The Concord Prison Experiment, conducted from 1961 to 1963, was designed to evaluate whether the experiences produced by the psychoactive drug psilocybin, derived from psilocybin mushrooms, combined with psychotherapy, could inspire prisoners to l ...
was designed to evaluate whether the experiences produced by the psychoactive drug
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
, derived from
psilocybin mushrooms Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocybe'', ''Pan ...
, combined with
psychotherapy Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly when based on regular personal interaction, to help a person change behavior, increase happiness, and overcome pro ...
, could inspire prisoners to leave their
antisocial Antisocial may refer to: Sociology, psychiatry and psychology *Anti-social behaviour *Antisocial personality disorder *Psychopathy *Conduct disorder Law *Anti-social Behaviour Act 2003 *Anti-Social Behaviour Order *Crime and Disorder Act 1998 * ...
lifestyles behind once they were released. How well it worked was to be judged by comparing the
recidivism Recidivism (; from ''recidive'' and ''ism'', from Latin ''recidīvus'' "recurring", from ''re-'' "back" and ''cadō'' "I fall") is the act of a person repeating an undesirable behavior after they have experienced negative consequences of th ...
rate of subjects who received psilocybin with the average for other Concord inmates. The experiment was conducted between February 1961 and January 1963 in Concord State Prison, a
maximum-security prison Maximum security prisons and supermax prisons are grades of high security level used by prison systems in various countries, which pose a higher level of security to prevent prisoners from escaping and/or doing harm to other inmates or security guar ...
for young offenders, in
Concord, Massachusetts Concord () is a town in Middlesex County, Massachusetts, in the United States. At the 2020 census, the town population was 18,491. The United States Census Bureau considers Concord part of Greater Boston. The town center is near where the conflu ...
by a team of
Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
researchers. The team were under the direction of
Timothy Leary Timothy Francis Leary (October 22, 1920 – May 31, 1996) was an American psychologist and author known for his strong advocacy of psychedelic drugs. Evaluations of Leary are polarized, ranging from bold oracle to publicity hound. He was "a her ...
and included
Michael Hollingshead Michael Hollingshead (?–1984?) was a British researcher who studied psychedelic drugs, including psilocybin and LSD, at Harvard University in the mid-20th century. He was the father of comedian Vanessa Hollingshead. He evangelized the use of LS ...
, Allan Cohen, Alfred Alschuder, George Litwin,
Ralph Metzner Ralph Metzner (May 18, 1936 – March 14, 2019) was a German-born American psychologist, writer and researcher, who participated in psychedelic research at Harvard University in the early 1960s with Timothy Leary and Richard Alpert (later named ...
, Gunther Weil, and Ralph Schwitzgebel, with Madison Presnell as the medical and psychiatric adviser. The original study involved the administration of
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
manufactured by
Sandoz Pharmaceuticals Novartis AG is a Swiss-American multinational pharmaceutical corporation based in Basel, Switzerland and Cambridge, Massachusetts, United States (global research).name="novartis.com">https://www.novartis.com/research-development/research-loc ...
to assist
group psychotherapy Group psychotherapy or group therapy is a form of psychotherapy in which one or more therapists treat a small group of clients together as a group. The term can legitimately refer to any form of psychotherapy when delivered in a group format, ...
for 32 prisoners in an effort to reduce
recidivism Recidivism (; from ''recidive'' and ''ism'', from Latin ''recidīvus'' "recurring", from ''re-'' "back" and ''cadō'' "I fall") is the act of a person repeating an undesirable behavior after they have experienced negative consequences of th ...
rates. The researchers would administer psilocybin to themselves along with the prisoners, on the grounds of " reatinga sense of equality and shared experience, and to dispel the fear that often accompanies relationships between xperimentersand ubjects.


Alexander Shulgin

Alexander Shulgin obtained a DEA Schedule I license for an analytical laboratory, which allowed him to synthesize and possess any otherwise ilcit drug, in order to work with scheduled psychoactive chemicals and set up a
chemical synthesis As a topic of chemistry, chemical synthesis (or combination) is the artificial execution of chemical reactions to obtain one or several products. This occurs by physical and chemical manipulations usually involving one or more reactions. In moder ...
laboratory in a small building behind his house, which gave him a great deal of career autonomy. Shulgin used this freedom to synthesize and test the effects of potentially
psychoactive drug A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. ...
s. In 1970s developed new methods of synthesis of
MDMA 3,4-Methylenedioxymethamphetamine (MDMA), commonly seen in Tablet (pharmacy), tablet form (ecstasy) and crystal form (molly or mandy), is a potent empathogen–entactogen with stimulant properties primarily used for Recreational dru ...
, a drug commonly associated with dance parties,
rave A rave (from the verb: '' to rave'') is a dance party at a warehouse, club, or other public or private venue, typically featuring performances by DJs playing electronic dance music. The style is most associated with the early 1990s dance mus ...
s, and electronic dance music. It may be mixed with other substances such as
ephedrine Ephedrine is a central nervous system (CNS) stimulant that is often used to prevent low blood pressure during anesthesia. It has also been used for asthma, narcolepsy, and obesity but is not the preferred treatment. It is of unclear benefit in ...
,
amphetamine Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...
, and
methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamph ...
. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population). This was broadly similar to the percentage of people who use
cocaine Cocaine (from , from , ultimately from Quechuan languages, Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly recreational drug use, used recreationally for its euphoria, euphoric effects. It is primarily obtained from t ...
or
amphetamine Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...
s, but lower than for
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: ''Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternatively ...
or
opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid us ...
s. In the United States, as of 2017, about 7% of people have used MDMA at some point in their lives and 0.9% have used it in the last year.


Terence McKenna

Terence McKenna, along with his brother Dennis, developed a technique for
cultivating Tillage is the agricultural preparation of soil by mechanical agitation of various types, such as digging, stirring, and overturning. Examples of human-powered tilling methods using hand tools include shoveling, picking, mattock work, hoeing ...
psilocybin mushrooms Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocybe'', ''Pan ...
using
spores In biology, a spore is a unit of sexual or asexual reproduction that may be adapted for dispersal and for survival, often for extended periods of time, in unfavourable conditions. Spores form part of the life cycles of many plants, algae, f ...
they brought to America from the
Amazon Amazon most often refers to: * Amazons, a tribe of female warriors in Greek mythology * Amazon rainforest, a rainforest covering most of the Amazon basin * Amazon River, in South America * Amazon (company), an American multinational technology c ...
. In 1976, the brothers published what they had learned in the book ''Psilocybin: Magic Mushroom Grower's Guide'', under the pseudonyms "O.T. Oss" and "O.N. Oeric". McKenna and his brother were the first to come up with a reliable method for cultivating
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
mushrooms at home. As
ethnobiologist ] Ethnobiology is the scientific study of the way living things are treated or used by different human cultures. It studies the dynamic relationships between people, biota, and environments, from the distant past to the immediate present.culture ...
Jonathan Ott Jonathan Ott (born 1949 in Hartford, Connecticut) is an ethnobotanist, writer, translator, publisher, natural products chemist and botanical researcher in the area of entheogens and their cultural and historical uses, and helped coin the term "'' ...
explains, " heauthors adapted San Antonio's technique (for producing
edible mushrooms Edible mushrooms are the fleshy and edible fruit bodies of several species of macrofungi (fungi which bear fruiting structures that are large enough to be seen with the naked eye). They can appear either below ground ( hypogeous) or above grou ...
by casing
mycelial Mycelium (plural mycelia) is a root-like structure of a fungus consisting of a mass of branching, thread-like hyphae. Fungal colonies composed of mycelium are found in and on soil and many other substrate (biology), substrates. A typical single ...
cultures on a rye grain substrate; San Antonio 1971) to the production of ''Psilocybe trophariacubensis''. The new technique involved the use of ordinary kitchen implements, and for the first time the layperson was able to produce a potent entheogen in his
r her R, or r, is the eighteenth letter of the Latin alphabet, used in the modern English alphabet, the alphabets of other western European languages and others worldwide. Its name in English is ''ar'' (pronounced ), plural ''ars'', or in Irela ...
own home, without access to sophisticated technology, equipment, or chemical supplies." When the 1986 revised edition was published, the ''Magic Mushroom Grower's Guide'' had sold over 100,000 copies.


Heffter Research Institute

In 1993 by
David E. Nichols David Earl Nichols (born December 23, 1944, Covington, Kentucky) is an Americans, American pharmacologist and medicinal chemist. Previously the Robert C. and Charlotte P. Anderson Distinguished Chair in Pharmacology at Purdue University, Nichol ...
, Mark Geyer, George Greer, Charles Grob, and
Dennis McKenna Dennis Jon McKenna (born December 17, 1950 in Paonia, Colorado) is an American ethnopharmacologist, research pharmacognosist, lecturer and author. He is the brother of well-known psychedelics proponent Terence McKenna and is a founding board ...
founded the Heffter Research Institute, a
501(c)(3) A 501(c)(3) organization is a United States corporation, trust, unincorporated association or other type of organization exempt from federal income tax under section 501(c)(3) of Title 26 of the United States Code. It is one of the 29 types of 50 ...
nonprofit organization A nonprofit organization (NPO) or non-profit organisation, also known as a non-business entity, not-for-profit organization, or nonprofit institution, is a legal entity organized and operated for a collective, public or social benefit, in co ...
that promotes research with classic
hallucinogen Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized ...
s and
psychedelics Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of ...
, predominantly
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
, to contribute to a greater understanding of the mind and to alleviate suffering. Founded in 1993 as a virtual institute, Heffter primarily funds academic and clinical scientists and made more than $3.1 million in grants between 2011 and 2014. Heffter's recent
clinical studies Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...
have focused on psilocybin-assisted treatment for end-of-life
anxiety Anxiety is an emotion which is characterized by an unpleasant state of inner turmoil and includes feelings of dread over anticipated events. Anxiety is different than fear in that the former is defined as the anticipation of a future threat wh ...
and depression in
cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...
patients, as well as alcohol and nicotine
addiction Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use o ...
. Several Heffter-supported studies on Spiritual experiences and practices involving
ayahuasca AyahuascaPronounced as in the UK and in the US. Also occasionally known in English as ''ayaguasca'' (Spanish-derived), ''aioasca'' (Brazilian Portuguese-derived), or as ''yagé'', pronounced or . Etymologically, all forms but ''yagé'' descen ...
and
psilocybin Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P.&nbs ...
have been published.


Influence on artistic movements

Some of the figures are were-eagle, bat-like features, and were-jaguars, most common, however, is the jaguar transformation figurine which show a wide variety of styles, ranging from human-like figurines to those that are almost completely jaguar, and several where the subject appears to be in a stage of transformation.


Influence on religion

The
Maya Maya may refer to: Civilizations * Maya peoples, of southern Mexico and northern Central America ** Maya civilization, the historical civilization of the Maya peoples ** Maya language, the languages of the Maya peoples * Maya (Ethiopia), a populat ...
displayed characteristic Mesoamerican mythology, with a strong emphasis on an individual being a communicator between the physical world and the spiritual world. Mushroom stone effigies, dated to 1000 BCE, give evidence that mushrooms were at least revered in a religious way.Tedlock 1992:46–53


See also

*
Psilocybin therapy Psilocybin therapy is the use of psilocybin (the psychoactive ingredient in psilocybin mushrooms) in treating a range of mental health conditions, such as depression, anxiety, addictions, obsessive compulsive disorder, and psychosis. It is one of s ...
*
List of substances used in rituals This page lists substances used in ritualistic context. Psychoactive use Entheogens This is a list of species and genera that are used as entheogens or are used in an entheogenic concoction (such as ayahuasca). For ritualistic use they may be cl ...
* Ancient use of cannabis *
Psychopharmacology Psychopharmacology (from Greek grc, ψῡχή, psȳkhē, breath, life, soul, label=none; grc, φάρμακον, pharmakon, drug, label=none; and grc, -λογία, -logia, label=none) is the scientific study of the effects drugs have on m ...
*
List of psychoactive plants, fungi, and animals This is a list of psychoactive plants, fungi, and animals. Plants Psychoactive plants include, but are not limited to, the following examples: * ''Cannabis'': cannabinoids * Tobacco: nicotine and beta-carboline alkaloids * Coca: cocaine * O ...
*
Psilocybin mushrooms Psilocybin mushrooms, commonly known as magic mushrooms, are a polyphyletic informal group of fungi that contain psilocybin which turns into psilocin upon ingestion. Biological genera containing psilocybin mushrooms include ''Psilocybe'', ''Pan ...
*
Psychoactive cacti Many Cactus, cacti are known to be psychoactive drug, psychoactive, containing substituted phenethylamine, phenethylamine alkaloids such as mescaline. However, the two main ritualistic (folkloric) genera are ''Echinopsis'', of which the most psycho ...
* History of LSD *
Entheogenic drugs and the archaeological record Entheogenic drugs have been used by various groups for thousands of years. There are numerous historical reports as well as modern, contemporary reports of indigenous groups using entheogens, chemical substances used in a religious, shamanic, or s ...


References

{{Reflist


External links

Psychedelic Timeline
by Tom Frame. Psychedelic Times. Religious practices Shamanism Spirituality Drug classes defined by psychological effects Drugs with non-standard legal status Drug culture Spiritual practice