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Mescaline
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic effects comparable to those of LSD and psilocybin. Biological sources It occurs naturally in several species of cacti. It is also found in small amounts in certain members of the bean family, Fabaceae, including ''Acacia berlandieri''. However those claims concerning ''Acacia'' species have been challenged and have been unsupported in any additional analysis. History and use Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico. Europeans noted use of peyote in Native American religious ceremonies upon early contact, notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador. While religious and ceremonial peyote use was widespread in the Aztec empire and northern M ...
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Psychedelic Drug
Psychedelics are a subclass of hallucinogenic drugs whose primary effect is to trigger non-ordinary states of consciousness (known as psychedelic experiences or "trips").Pollan, Michael (2018). ''How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence'' Sometimes, they are called classic hallucinogens, serotonergic hallucinogens, or serotonergic psychedelics, and the term ''psychedelics'' is used more broadly to include all hallucinogens; this article uses the narrower definition of ''psychedelics''. Psychedelics cause specific psychological, visual, and auditory changes, and often a substantially altered state of consciousness.Leary, Timothy; Metzner, Ralph (1964). ''The Psychedelic Experience: A Manual Based on The Tibetan Book of the Dead'' Psychedelic states are often compared to meditative, psychodynamic or transcendental types of alterations of mind. The "classical" psychedelics, the psy ...
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Peyote
The peyote (; ''Lophophora williamsii'' ) is a small, spineless cactus which contains psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar cocoon", from a root , "to glisten". p. 246. See peyotl in Wiktionary. Peyote is native to Mexico and southwestern Texas. It is found primarily in the Sierra Madre Occidental, the Chihuahuan Desert and in the states of Nayarit, Coahuila, Nuevo León, Tamaulipas, and San Luis Potosí among scrub. It flowers from March to May, and sometimes as late as September. The flowers are pink, with thigmotactic anthers (like ''Opuntia''). Known for its psychoactive properties when ingested, peyote has at least 5,500 years of entheogenic and traditional medicine, medicinal use by Indigenous people of the Americas, indigenous North Americans. Description The various species of the genus ''Lophophora'' grow low to the ground and they often form groups with numerous, crowded sho ...
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Hallucinogen
Hallucinogens are a large, diverse class of psychoactive drugs that can produce altered states of consciousness characterized by major alterations in thought, mood, and perception as well as other changes. Most hallucinogens can be categorized as either being psychedelics, dissociatives, or deliriants. However, certain hallucinogens such as Fly agaric as well as other gabaergic hallucinogenics are more often considered to technically be hypnotics, therefore indicating another separate subcategory of drugs which can substantially alter visual perception. Etymology The word ''hallucinogen'' is derived from the word ''hallucination''. The term ''hallucinate'' dates back to around 1595–1605, and is derived from the Latin ''hallūcinātus'', the past participle of ''(h)allūcināri'', meaning "to wander in the mind." Characteristics Leo Hollister gave five criteria for classifying a drug as hallucinogenic.Glennon RA. Classical drugs: an introductory overview. In Lin GC and Gle ...
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Lysergic Acid Diethylamide
Lysergic acid diethylamide (LSD), also known colloquially as acid, is a potent psychedelic drug. Effects typically include intensified thoughts, emotions, and sensory perception. At sufficiently high dosages LSD manifests primarily mental, visual, as well as auditory, hallucinations. Dilated pupils, increased blood pressure, and increased body temperature are typical. Effects typically begin within half an hour and can last for up to 20 hours. LSD is also capable of causing mystical experiences and ego dissolution. It is used mainly as a recreational drug or for spiritual reasons. LSD is both the prototypical psychedelic and one of the "classical" psychedelics, being the psychedelics with the greatest scientific and cultural significance. LSD is typically either swallowed or held under the tongue. It is most often sold on blotter paper and less commonly as tablets, in a watery solution or in gelatin squares called panes. LSD is considered to be non-addictive with low potent ...
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Peyote
The peyote (; ''Lophophora williamsii'' ) is a small, spineless cactus which contains psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar cocoon", from a root , "to glisten". p. 246. See peyotl in Wiktionary. Peyote is native to Mexico and southwestern Texas. It is found primarily in the Sierra Madre Occidental, the Chihuahuan Desert and in the states of Nayarit, Coahuila, Nuevo León, Tamaulipas, and San Luis Potosí among scrub. It flowers from March to May, and sometimes as late as September. The flowers are pink, with thigmotactic anthers (like ''Opuntia''). Known for its psychoactive properties when ingested, peyote has at least 5,500 years of entheogenic and traditional medicine, medicinal use by Indigenous people of the Americas, indigenous North Americans. Description The various species of the genus ''Lophophora'' grow low to the ground and they often form groups with numerous, crowded sho ...
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Echinopsis Peruviana
''Echinopsis peruviana'' (syn. ''Trichocereus peruvianus''), the Peruvian torch cactus, is a fast-growing columnar cactus native to the western slope of the Andes in Peru, between about above sea level. Description The plant is bluish-green in color, with frosted stems, and 6-9 broadly rounded ribs; it has large, white flowers. It can grow up to tall, with stems up to in diameter; it is fully erect to begin with, but later possibly arching over, or even becoming prostrate. Groups of 6-8 honey-colored to brown rigid spines, up to in length, with most about , are located at the nodes, which are evenly spaced along the ribs, up to approximately apart. Taxonomy Subspecies ''Echinopsis peruviana'' ssp. ''puquiensis'' (Rauh & Backeb.) Ostolaza Varieties Some varieties, with scientifically invalid names, of ''Echinopsis peruviana'' are: * var. ''ancash'' (KK1688), San Marcos, Ancash, northwest Peru. * var. ''ayacuchensis'' (KK2151), southwestern Peru. * var. ''cuzcoensis'' (KK ...
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Psychoactive Cactus
Many cacti are known to be psychoactive, containing phenethylamine alkaloids such as mescaline. However, the two main ritualistic (folkloric) genera are ''Echinopsis'', of which the most psychoactive species is the San Pedro cactus (''Echinopsis pachanoi'', syn. ''Trichocereus pachanoi''), and ''Lophophora'', with peyote (''Lophophora williamsii'') being the most psychoactive species. Several other species pertaining to other genera are also psychoactive, though not always used with a ritualistic intent. Species Globular cacti *''Lophophora williamsii'' (peyote) Other "peyotes" *''Ariocarpus fissuratus'' *''Coryphantha compacta'' (syn. ''C. palmeri'') *''Pelecyphora aselliformis'' *''Pelecyphora strobiliformis'' *''Lophophora diffusa'' *''Ariocarpus retusus'' *''Ariocarpus agavoides''; '' kotschoubeyanus''; and other species *''Astrophytum asterias''; '' capricorne''; '' myriostigma''; and other species *''Aztekium ritteri''; and other species *''Coryphantha elephantidens''; ...
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Echinopsis Pachanoi
''Echinopsis pachanoi'' (syn. ''Trichocereus pachanoi'')—known as San Pedro cactus—is a fast-growing columnar cactus native to the Andes Mountains at in altitude. It is found in Argentina, Bolivia, Colombia, Chile, Ecuador and Peru, and it is cultivated in other parts of the world. Uses for it include traditional medicine and traditional veterinary medicine, and it is widely grown as an ornamental cactus. It has been used for healing and religious divination in the Andes Mountains region for over 3,000 years. It is sometimes confused with its close relative ''Echinopsis peruviana'' (Peruvian torch cactus). Taxonomy Echinopsis pachanoi is known by many names throughout South America such as ''achuma,'' ''huachuma,'' ''wachuma,'' ''aguacolla,'' ''hahuacollay,'' ''San Pedro'' or ''giganton''. Description ''Echinopsis pachanoi'' is native to Ecuador and Peru. Its stems are light to dark green, sometimes glaucous, with a diameter of and usually 6–8 ribs. The whitish areoles m ...
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Humphry Osmond
Humphry Fortescue Osmond (1 July 1917 – 6 February 2004) was an English psychiatrist who expatriated to Canada, then moved to work in the United States. He is known for inventing the word '' psychedelic'' and for his research into interesting and useful applications for psychedelic drugs. Osmond also explored aspects of the psychology of social environments, in particular how they influenced welfare or recovery in mental institutions. Biography Osmond was born in Surrey, England, and educated at Haileybury. As a young man, he worked for an architect and attended Guy's Hospital Medical School at King's College London. While active as a surgeon-lieutenant in the Navy during World War II, Osmond trained to become a psychiatrist. Work with psychedelics After the war, Osmond joined the psychiatric unit at St George's Hospital, London, where he rose to become senior registrar. His time at the hospital proved pivotal in three respects: it was where he met his wife Amy "Jane" Rof ...
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Echinopsis Lageniformis
''Echinopsis lageniformis'' (syn. ''Trichocereus bridgesii''), the Bolivian torch cactus, is a fast-growing columnar cactus from the high deserts of Bolivia. Among the indigenous populations of Bolivia, it is sometimes called ''achuma'' or ''wachuma'', although these names are also applied to related species such as ''Echinopsis pachanoi'' which are also used for their psychedelic effects. Description The plant has a greenish to bluish color and usually has four to eight ribs. It can grow tall with stems of up to in diameter. Spines can range in coloration from honey-coloured to brown, and are located on the nodes in groups of up to four. These spines can grow up to 6–7 cm in length and in fully grown plants are spaced evenly on the ribs, 2.5 to 3 cm apart. Cultivars Several varieties of this species are highly prized by ornamental cactus collectors. These include a cristate variety, two variants of monstrose growth, and a more recently developed clone that e ...
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Alkaloid
Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar structure may also be termed alkaloids. In addition to carbon, hydrogen and nitrogen, alkaloids may also contain oxygen, sulfur and, more rarely, other elements such as chlorine, bromine, and phosphorus.Chemical Encyclopedia: alkaloids
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Alkaloids are produced by a large variety of organisms including , , Medicinal plant, plants, an ...
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Psilocybin
Psilocybin ( , ) is a naturally occurring psychedelic prodrug compound produced by more than 200 species of fungi. The most potent are members of the genus ''Psilocybe'', such as '' P. azurescens'', '' P. semilanceata'', and '' P. cyanescens'', but psilocybin has also been isolated from about a dozen other genera. Psilocybin is itself biologically inactive but is quickly converted by the body to psilocin, which has mind-altering effects similar, in some aspects, to those of LSD, mescaline, and DMT. In general, the effects include euphoria, visual and mental hallucinations, changes in perception, a distorted sense of time, and perceived spiritual experiences. It can also cause adverse reactions such as nausea and panic attacks. Imagery found on prehistoric murals and rock paintings of modern-day Spain and Algeria suggests that human usage of psilocybin mushrooms predates recorded history. In Mesoamerica, the mushrooms had long been consumed in spiritual and div ...
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