The Hepatitis C virus (HCV) cis-acting replication element (CRE) is an
RNA element which is found in the coding region of the
RNA-dependent RNA polymerase
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
NS5B
Nonstructural protein 5B (NS5B) is a viral protein found in the hepatitis C virus (HCV). It is an RNA-dependent RNA polymerase, having the key function of replicating HCV's viral RNA by using the viral positive RNA strand as a template to catalyze ...
. Mutations in this family have been found to cause a blockage in
RNA replication
RNA-dependent RNA polymerase (RdRp) or RNA replicase is an enzyme that catalyzes the replication of RNA from an RNA template. Specifically, it catalyzes synthesis of the RNA strand complementary to a given RNA template. This is in contrast to t ...
and it is thought that both the primary sequence and the structure of this element are crucial for HCV RNA replication.
See also
*
Hepatitis C alternative reading frame stem-loop
Hepatitis C alternative reading frame stem-loop is a conserved secondary structure motif identified in the RNA genome of the Hepatitis C virus (HCV) which is proposed to have an important role in regulating Translation (biology), translation and r ...
*
Hepatitis C virus 3'X element
The hepatitis C virus 3′X element is an RNA element which contains three stem-loop structures that are essential for replication.
See also
* Hepatitis C alternative reading frame stem-loop
* Hepatitis C stem-loop IV
* Hepatitis C virus ste ...
*
Hepatitis C virus stem-loop VII
Hepatitis C virus stem-loop VII is a Cis-regulatory element, regulatory element found in the coding region of the RNA-dependent RNA polymerase gene, NS5B. Similarly to Hepatitis C stem-loop IV, stem-loop IV, the stem-loop structure is important (b ...
*
Hepatitis C stem-loop IV
The Hepatitis C stem-loop IV is part of a putative cis-regulatory element, RNA element found in the NS5B coding region. This element along with Hepatitis C virus stem-loop VII, stem-loop VII, is important (but not essential) for colony formation, ...
*
Hepatitis C
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver; it is a type of viral hepatitis. During the initial infection people often have mild or no symptoms. Occasionally a fever, dark urine, a ...
References
External links
*
Cis-regulatory RNA elements
Hepatitis C virus
{{molecular-cell-biology-stub