Haplogroup I is a
human mitochondrial DNA
Human mitochondrial genetics is the study of the genetics of human mitochondrial DNA (the DNA contained in human mitochondria). The human mitochondrial genome is the entirety of hereditary information contained in human mitochondria. Mitochondri ...
(mtDNA) haplogroup. It is believed to have originated about 21,000 years ago, during the
Last Glacial Maximum
The Last Glacial Maximum (LGM), also referred to as the Late Glacial Maximum, was the most recent time during the Last Glacial Period that ice sheets were at their greatest extent.
Ice sheets covered much of Northern North America, Northern Eur ...
(LGM) period in
West Asia
Western Asia, West Asia, or Southwest Asia, is the westernmost subregion of the larger geographical region of Asia, as defined by some academics, UN bodies and other institutions. It is almost entirely a part of the Middle East, and includes Ana ...
(; ; ). The haplogroup is unusual in that it is now widely distributed geographically, but is common in only a few small areas of
East Africa
East Africa, Eastern Africa, or East of Africa, is the eastern subregion of the African continent. In the United Nations Statistics Division scheme of geographic regions, 10-11-(16*) territories make up Eastern Africa:
Due to the historical ...
, West Asia and
Europe
Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...
. It is especially common among the
El Molo
The El Molo, also known as Elmolo, Dehes, Fura-Pawa and Ldes, are an ethnic group mainly inhabiting the northern Eastern Province of Kenya. They historically spoke the El Molo language as a mother tongue, an Afro-Asiatic language of the Cushitic ...
and
Rendille peoples of Kenya, various regions of
Iran
Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...
, the
Lemko people
Lemkos ( rue, Лeмкы, translit= Lemkŷ; pl, Łemkowie; uk, Лемки, translit=Lemky) are an ethnic group inhabiting the Lemko Region ( rue, Лемковина, translit=Lemkovyna; uk, Лемківщина, translit=Lemkivshchyna) of Ca ...
of Slovakia, Poland and Ukraine, the island of
Krk
Krk (; it, Veglia; ruo, Krk; dlm, label= Vegliot Dalmatian, Vikla; la, Curicta; grc-gre, Κύρικον, Kyrikon) is a Croatian island in the northern Adriatic Sea, located near Rijeka in the Bay of Kvarner and part of Primorje-Gorski Kot ...
in Croatia, the department of
Finistère
Finistère (, ; br, Penn-ar-Bed ) is a department of France in the extreme west of Brittany. In 2019, it had a population of 915,090. in France and some parts of
Scotland
Scotland (, ) is a country that is part of the United Kingdom. Covering the northern third of the island of Great Britain, mainland Scotland has a border with England to the southeast and is otherwise surrounded by the Atlantic Ocean to the ...
and
Ireland
Ireland ( ; ga, Éire ; Ulster Scots dialect, Ulster-Scots: ) is an island in the Atlantic Ocean, North Atlantic Ocean, in Northwestern Europe, north-western Europe. It is separated from Great Britain to its east by the North Channel (Grea ...
.
Origin
Haplogroup I is a descendant (
subclade
In genetics, a subclade is a subgroup of a haplogroup.
Naming convention
Although human mitochondrial DNA (mtDNA) and Y chromosome DNA (Y-DNA) haplogroups and subclades are named in a similar manner, their names belong to completely separate sy ...
) of haplogroup N1a1b and sibling of haplogroup N1a1b1 . It is believed to have arisen somewhere in West Asia between 17,263 and 24,451 years
before present
Before Present (BP) years, or "years before present", is a time scale used mainly in archaeology, geology and other scientific disciplines to specify when events occurred relative to the origin of practical radiocarbon dating in the 1950s. Becaus ...
(BP) , with coalescence age of 20.1 thousand years ago . It has been suggested that its origin may be in Iran or more generally the Near East . It has diverged to at least seven distinct clades i.e. branches I1–I7, dated between 16–6.8 thousand years . The hypothesis about its Near Eastern origin is based on the fact that all haplogroup I clades, especially those from Late Glacial period (I1, I4, I5, and I6), include mitogenomes from the Near East . The age estimates and dispersal of some subclades (I1, I2’3, I5) are similar to those of major subclades of the mtDNA haplogroups
J and
T, indicating possible dispersal of the I haplogroup into Europe during the Late Glacial period (c. 18–12 kya) and postglacial period (c. 10–11 kya), several millennia before the European Neolithic period. Some subclades (I1a1, I2, I1c1, I3) show signs of the Neolithic diffusion of agriculture and pastoralism within Europe .
A similar view puts more emphasis on the
Persian Gulf
The Persian Gulf ( fa, خلیج فارس, translit=xalij-e fârs, lit=Gulf of Persis, Fars, ), sometimes called the ( ar, اَلْخَلِيْجُ ٱلْعَرَبِيُّ, Al-Khalīj al-ˁArabī), is a Mediterranean sea (oceanography), me ...
region of the Near East .
Distribution
Haplogroup I is found at moderate to low frequencies in
East Africa
East Africa, Eastern Africa, or East of Africa, is the eastern subregion of the African continent. In the United Nations Statistics Division scheme of geographic regions, 10-11-(16*) territories make up Eastern Africa:
Due to the historical ...
,
Europe
Europe is a large peninsula conventionally considered a continent in its own right because of its great physical size and the weight of its history and traditions. Europe is also considered a Continent#Subcontinents, subcontinent of Eurasia ...
,
West Asia
Western Asia, West Asia, or Southwest Asia, is the westernmost subregion of the larger geographical region of Asia, as defined by some academics, UN bodies and other institutions. It is almost entirely a part of the Middle East, and includes Ana ...
and
South Asia
South Asia is the southern subregion of Asia, which is defined in both geographical and ethno-cultural terms. The region consists of the countries of Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka.;;;;;;;; ...
. In addition to the confirmed seven clades, the rare basal/paraphyletic clade I* has been observed in three individuals; two from
Somalia
Somalia, , Osmanya script: 𐒈𐒝𐒑𐒛𐒐𐒘𐒕𐒖; ar, الصومال, aṣ-Ṣūmāl officially the Federal Republic of SomaliaThe ''Federal Republic of Somalia'' is the country's name per Article 1 of thProvisional Constituti ...
and one from
Iran
Iran, officially the Islamic Republic of Iran, and also called Persia, is a country located in Western Asia. It is bordered by Iraq and Turkey to the west, by Azerbaijan and Armenia to the northwest, by the Caspian Sea and Turkmeni ...
.
Africa
The highest frequencies of mitochondrial haplogroup I observed so far appear in the
Cushitic
The Cushitic languages are a branch of the Afroasiatic language family. They are spoken primarily in the Horn of Africa, with minorities speaking Cushitic languages to the north in Egypt and the Sudan, and to the south in Kenya and Tanzania. As o ...
-speaking
El Molo
The El Molo, also known as Elmolo, Dehes, Fura-Pawa and Ldes, are an ethnic group mainly inhabiting the northern Eastern Province of Kenya. They historically spoke the El Molo language as a mother tongue, an Afro-Asiatic language of the Cushitic ...
(23%) and
Rendille (>17%) in northern Kenya . The clade is also found at comparable frequencies among the
Soqotri (~22%).
Asia
Haplogroup I is present across West Asia and Central Asia, and is also found at trace frequencies in South Asia. Its highest frequency area is perhaps in northern Iran (9.7%). Terreros 2011 notes that it also has high diversity there and reiterates past studies that have suggested that this may be its place of origin. Found in Svan population from Georgia(Caucasus) I* 4.2%."Sequence polymorphisms of the mtDNA control region in a human isolate: the Georgians from Swanetia."Alfonso-Sánchez MA1, Martínez-Bouzas C, Castro A, Peña JA, Fernández-Fernández I, Herrera RJ, de Pancorbo MM. The table below shows some of the populations where it has been detected.
Europe
Western Europe
In Western Europe, haplogroup I is most common in Northwestern Europe (Norway, the Isle of Skye, and the British Isles). The frequency in these areas is between 2 and 5 percent. Its highest frequency in Brittany, France where it is over 9 percent of the population in
Finistère
Finistère (, ; br, Penn-ar-Bed ) is a department of France in the extreme west of Brittany. In 2019, it had a population of 915,090. . It is uncommon and sometimes absent in other parts of Western Europe (Iberia, South-West France, and parts of Italy).
Eastern Europe
In Eastern Europe, the frequency of haplogroup I is generally lower than in Western Europe (1 to 3 percent), but its frequency is more consistent between populations with fewer places of extreme highs or lows. There are two notable exceptions. Nikitin 2009 found that
Lemkos
Lemkos ( rue, Лeмкы, translit= Lemkŷ; pl, Łemkowie; uk, Лемки, translit=Lemky) are an ethnic group inhabiting the Lemko Region ( rue, Лемковина, translit=Lemkovyna; uk, Лемківщина, translit=Lemkivshchyna) of Car ...
(a sub- or co-ethnic group of
Rusyns
Rusyns (), also known as Carpatho-Rusyns (), or Rusnaks (), are an East Slavs, East Slavic ethnic group from the Carpathian Rus', Eastern Carpathians in Central Europe. They speak Rusyn language, Rusyn, an East Slavic languages, East Slavi ...
) in the
Carpathian mountains
The Carpathian Mountains or Carpathians () are a range of mountains forming an arc across Central Europe. Roughly long, it is the third-longest European mountain range after the Urals at and the Scandinavian Mountains at . The range stretches ...
have the "highest frequency of haplogroup I (11.3%) in Europe, identical to that of the population of
Krk
Krk (; it, Veglia; ruo, Krk; dlm, label= Vegliot Dalmatian, Vikla; la, Curicta; grc-gre, Κύρικον, Kyrikon) is a Croatian island in the northern Adriatic Sea, located near Rijeka in the Bay of Kvarner and part of Primorje-Gorski Kot ...
Island (Croatia) in the Adriatic Sea".
[Nikitin 2009: 6/53 in Lemkos]
''"Lemkos shared the highest frequency of haplogroup I ever reported and the highest frequency of haplogroup M* in the region."''[: 15/133]
Historic and Pre-Historic Samples
Haplogroup I has until recently been absent from ancient European samples found in Paleolithic and Mesolithic grave sites. In 2017, in a site on Italian island of
Sardinia
Sardinia ( ; it, Sardegna, label=Italian, Corsican and Tabarchino ; sc, Sardigna , sdc, Sardhigna; french: Sardaigne; sdn, Saldigna; ca, Sardenya, label=Algherese and Catalan) is the second-largest island in the Mediterranean Sea, after ...
was found a sample with the subclade I3 dated to 9124–7851 BC , while in the Near East, in Levant was found a sample with yet-not-defined subclade dated 8850–8750 BC, while in Iran was found a younger sample with subclade I1c dated to 3972–3800 BC . In Neolithic Spain (c. 6090–5960 BC in
Paternanbidea,
Navarre
Navarre (; es, Navarra ; eu, Nafarroa ), officially the Chartered Community of Navarre ( es, Comunidad Foral de Navarra, links=no ; eu, Nafarroako Foru Komunitatea, links=no ), is a foral autonomous community and province in northern Spain, ...
) was found a sample with yet-not-defined subclade . Haplogroup I displays a strong connection with the
Indo-European migrations
The Indo-European migrations were hypothesized migrations of Proto-Indo-European language (PIE) speakers, and subsequent migrations of people speaking derived Indo-European languages, which took place approx. 4000 to 1000 BCE, potentially expla ...
; especially its I1, I1a1 and I3a subclades, which have been found in
Poltavka and
Srubnaya cultures in
Russia
Russia (, , ), or the Russian Federation, is a List of transcontinental countries, transcontinental country spanning Eastern Europe and North Asia, Northern Asia. It is the List of countries and dependencies by area, largest country in the ...
(Mathieson 2015), among ancient
Scythia
Scythia (Scythian: ; Old Persian: ; Ancient Greek: ; Latin: ) or Scythica (Ancient Greek: ; Latin: ), also known as Pontic Scythia, was a kingdom created by the Scythians during the 6th to 3rd centuries BC in the Pontic–Caspian steppe.
Hi ...
ns (Der Sarkissian 2011), and in
Corded Ware
The Corded Ware culture comprises a broad archaeological horizon of Europe between ca. 3000 BC – 2350 BC, thus from the late Neolithic, through the Chalcolithic, Copper Age, and ending in the early Bronze Age. Corded Ware culture en ...
and
Unetice Culture
The Únětice culture or Aunjetitz culture ( cs, Únětická kultura, german: Aunjetitzer Kultur, pl, Kultura unietycka) is an archaeological culture at the start of the Central European Bronze Age, dated roughly to about 2300–1600BC. The epon ...
burials in Saxony ().I3a has also been found in the Unetice Culture in Lubingine, Germany 2,200 B.C. to 1,800 B.C. courtesy article on Unetice Culture Wikipedia of 2 Skeletons that were DNA tested. Haplogroup I (with undetermined subclades) has also been noted at significant frequencies in more recent historic grave sites ( and ).
In 2013, ''
Nature
Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...
'' announced the publication of the first genetic study utilizing
next-generation sequencing Massive parallel sequencing or massively parallel sequencing is any of several high-throughput approaches to DNA sequencing using the concept of massively parallel processing; it is also called next-generation sequencing (NGS) or second-generation s ...
to ascertain the ancestral lineage of an
Ancient Egyptian individual. The research was led by Carsten Pusch of the
University of Tübingen
The University of Tübingen, officially the Eberhard Karl University of Tübingen (german: Eberhard Karls Universität Tübingen; la, Universitas Eberhardina Carolina), is a public research university located in the city of Tübingen, Baden-Wü ...
in
Germany
Germany,, officially the Federal Republic of Germany, is a country in Central Europe. It is the second most populous country in Europe after Russia, and the most populous member state of the European Union. Germany is situated betwe ...
and Rabab Khairat, who released their findings in the ''Journal of Applied Genetics''. DNA was extracted from the heads of five Egyptian mummies that were housed at the institution. All the specimens were dated to between 806 BC and 124 AD, a time frame corresponding with the
Late Dynastic and
Ptolemaic Ptolemaic is the adjective formed from the name Ptolemy, and may refer to:
Pertaining to the Ptolemaic dynasty
* Ptolemaic dynasty, the Macedonian Greek dynasty that ruled Egypt founded in 305 BC by Ptolemy I Soter
* Ptolemaic Kingdom
Pertaining ...
periods. The researchers observed that one of the mummified individuals likely belonged to the I2 subclade. Haplogroup I has also been found among
ancient Egyptian mummies excavated at the
Abusir el-Meleq archaeological site in Middle Egypt, which date from the Pre-Ptolemaic/late
New Kingdom
New is an adjective referring to something recently made, discovered, or created.
New or NEW may refer to:
Music
* New, singer of K-pop group The Boyz
Albums and EPs
* ''New'' (album), by Paul McCartney, 2013
* ''New'' (EP), by Regurgitator, ...
,
Ptolemaic Ptolemaic is the adjective formed from the name Ptolemy, and may refer to:
Pertaining to the Ptolemaic dynasty
* Ptolemaic dynasty, the Macedonian Greek dynasty that ruled Egypt founded in 305 BC by Ptolemy I Soter
* Ptolemaic Kingdom
Pertaining ...
, and
Roman
Roman or Romans most often refers to:
*Rome, the capital city of Italy
*Ancient Rome, Roman civilization from 8th century BC to 5th century AD
*Roman people, the people of ancient Rome
*''Epistle to the Romans'', shortened to ''Romans'', a letter ...
periods.
Haplogroup I5 has also been observed among specimens at the mainland cemetery in
Kulubnarti Kulubnarti ("Kulb island") is a long island in northern Sudan. Located on the Nile, around south of the Egyptian border, it is part of the village of Kulb.
Until the fifteenth century, Kulubnarti was a remote area. It was one of the last known r ...
,
Sudan
Sudan ( or ; ar, السودان, as-Sūdān, officially the Republic of the Sudan ( ar, جمهورية السودان, link=no, Jumhūriyyat as-Sūdān), is a country in Northeast Africa. It shares borders with the Central African Republic t ...
, which date from the
Early Christian
Early Christianity (up to the First Council of Nicaea in 325) spread from the Levant, across the Roman Empire, and beyond. Originally, this progression was closely connected to already established Jewish centers in the Holy Land and the Jewish d ...
period (AD 550–800).
Samples with determined subclades
Samples with unknown subclades
The frequency of haplogroup I may have undergone a reduction in Europe following the Middle Ages. An overall frequency of 13% was found in ancient Danish samples from the Iron Age to the Medieval Age (including
Vikings
Vikings ; non, víkingr is the modern name given to seafaring people originally from Scandinavia (present-day Denmark, Norway and Sweden),
who from the late 8th to the late 11th centuries raided, pirated, traded and se ...
) from
Denmark
)
, song = ( en, "King Christian stood by the lofty mast")
, song_type = National and royal anthem
, image_map = EU-Denmark.svg
, map_caption =
, subdivision_type = Sovereign state
, subdivision_name = Danish Realm, Kingdom of Denmark
...
and
Scandinavia
Scandinavia; Sámi languages: /. ( ) is a subregion#Europe, subregion in Northern Europe, with strong historical, cultural, and linguistic ties between its constituent peoples. In English usage, ''Scandinavia'' most commonly refers to Denmark, ...
compared to only 2.5% in modern samples. As haplogroup I is not observed in any ancient Italian, Spanish
ontradicted by the recent research as have been found in pre-Neolithic Italy as well Neolithic Spain British, central European populations, early central European farmers and Neolithic samples, according to the authors "Haplogroup I could, therefore, have been an ancient Southern Scandinavian type "diluted" by later immigration events" .
Subclades
Tree
This phylogenetic tree of haplogroup I subclades with time estimates is based on the paper and published research .
Distribution
I1
It formed during the Last Glacial pre-warming period. It is found mainly in Europe, Near East, occasionally in North Africa and the Caucasus.
It is the most frequent clade of the haplogroup .
=I1a
=
The subclade frequency peaks (circa 2.8%) are mostly located in North-Eastern Europe .
I1a1
I1a1a
I1a1b
I1a1c
I1a1d
=I1b
=
=I1c
=
I2'3
It is the common root clade for subclades I2 and I3. There's a sample from Tanzania with which I2'3 shares a variant at position 152 from the root node of haplogroup I, and this "node 152" could be upstream I2'3s clade . Both I2 and I3 might have formed during the Holocene period, and most of their subclades are from Europe, only few from the Near East . Examples of this ancestral branch have not been documented.
=I2
=
I2a
I2a1
I2b
I2c
I2d
I2e
=I3
=
I3a
I3a1
I3b
I4
The clade splits into subclades I4a and newly defined I4b, with samples found in Europe, the Near East and the Caucasus .
=I4a
=
I5
Is the second most frequent clade of the haplogroup. Its subclades are found in Europe, e.g. I5a1, and the Near East, e.g. I5a2a and I5b .
=I5a
=
I5a1
I6
The subclade is very rare, found until July 2013 only in four samples from the Near East .
=I6a
=
I7
It is the rarest defined subclade, until July 2013 found only in two samples from the Near East and the Caucasus .
See also
Genetics
Backbone mtDNA Tree
References
Footnotes
Works Cited
Journals
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Websites
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Further reading
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External links
*General
**Ian Logan'
Mitochondrial DNA Site**Mannis van Oven'
*Haplogroup I
Family Tree DNA – mtDNA Haplogroup I Project
{{DEFAULTSORT:Haplogroup I (Mtdna)
I