H. Hugh Fudenberg
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Herman Hugh Fudenberg (October 24, 1928March 15, 2014) was an American clinical immunologist and the sole identified member of the Neuro Immuno Therapeutics Research Foundation (NITRF). Fudenberg was a proponent of the discredited hypothesis that there was a connection between the
MMR vaccine The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles), abbreviated as ''MMR''. The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, ...
and
autism The autism spectrum, often referred to as just autism or in the context of a professional diagnosis autism spectrum disorder (ASD) or autism spectrum condition (ASC), is a neurodevelopmental condition (or conditions) characterized by difficulti ...
. In 1995 Fudenberg's medical license was suspended for improperly obtaining
controlled substances A controlled substance is generally a drug or chemical whose manufacture, possession and use is regulated by a government, such as illicitly used drugs or prescription medications that are designated by law. Some treaties, notably the Single C ...
.


Education

He received his A.B. from
UCLA The University of California, Los Angeles (UCLA) is a public land-grant research university in Los Angeles, California. UCLA's academic roots were established in 1881 as a teachers college then known as the southern branch of the California St ...
in 1949 and his MD from the
University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...
in 1953. Fudenberg received his M.A. in immunochemistry from
Boston University Boston University (BU) is a private research university in Boston, Massachusetts. The university is nonsectarian, but has a historical affiliation with the United Methodist Church. It was founded in 1839 by Methodists with its original campu ...
in 1957.


Career

The areas of his research, conducted primarily in the 1960s and 1970s, included research into
immunoglobulin An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses. The antibody recognizes a unique molecule of the ...
and receptors for this molecule in human
monocyte Monocytes are a type of leukocyte or white blood cell. They are the largest type of leukocyte in blood and can differentiate into macrophages and conventional dendritic cells. As a part of the vertebrate innate immune system monocytes also inf ...
s, as well as the ability of red blood cells to, in vitro, form "rosette" formations around peripheral blood lymphocytes. Fudenberg was hired by the Special Projects Unit of the Council for Tobacco Research in 1972, to study whether some people are genetically predisposed to
emphysema Emphysema, or pulmonary emphysema, is a lower respiratory tract disease, characterised by air-filled spaces ( pneumatoses) in the lungs, that can vary in size and may be very large. The spaces are caused by the breakdown of the walls of the alve ...
. He initially found that up to 10% might be, and was planning on warning such people not to smoke tobacco, but his funding was cut off without explanation before he could do so. "They may have cut me off because it would have been negative for them," Fudenberg suggested. He trained from 1954 to 1956 under
William Dameshek William Dameshek (1900 in Voronezh – 1969) was an American hematologist. He graduated from Harvard College and Harvard Medical School and spent the early part of his career at Beth Israel Hospital (now Beth Israel Deaconess Medical Center). He ...
, former editor of ''
Blood Blood is a body fluid in the circulatory system of humans and other vertebrates that delivers necessary substances such as nutrients and oxygen to the cells, and transports metabolic waste products away from those same cells. Blood in the c ...
'' and completed a residency at Peter Bent Brigham Hospital from 1956 to 1958. Fudenberg was a professor of medicine for 15 years (first associate, and later full) at
University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...
, as well as associate professor of immunology at the
University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...
. He was editor of the journal ''Clinical Immunology and Immunopathology'' for 15 years and developed the
Rosette test Erythrocyte rosetting or E-rosetting is a phenomenon seen through a microscope where red blood cells ''(erythrocytes)'' are arranged around a central cell to form a cluster that looks like a flower. The red blood cells surrounding the cell form the ...
as well. Additionally, Fudenberg sat on the
World Health Organization The World Health Organization (WHO) is a specialized agency of the United Nations responsible for international public health. The WHO Constitution states its main objective as "the attainment by all peoples of the highest possible level of h ...
's expert committee on immunology for 20 years. In 1974, he relocated to South Carolina, specifically the
Medical University of South Carolina The Medical University of South Carolina (MUSC) is a public medical school in South Carolina. It opened in 1824 in Charleston as a small private college aimed at training physicians and has since established hospitals and medical facilities acr ...
, where he remained as a professor until 1989.


MMR vaccine and autism

In the 1980s Fudenberg began claiming that the MMR vaccine causes autism. The scientific consensus says that no evidence links the vaccine to the development of autism and that the vaccine's benefits greatly outweigh its risks. Fudenberg published his research in the fringe journal ''Biotherapy'' (now discontinued) in 1996, concluding that "Fifteen of the rue Autismpatients developed symptoms within a week after immunization with the MRvaccine"; further asserting that "Fudenberg healed children, with a quarter 'fully normalised'." This paper was cited by Andrew Wakefield's fraudulent 1998 Lancet paper. The proposal of a vaccine-autism link has been called "the most damaging medical hoax of the last 100 years". Fudenberg claimed in a 2004 interview with
Brian Deer Brian Deer is a British investigative reporter, best known for inquiries into the drug industry, medicine and social issues for ''The Sunday Times''. Deer's investigative nonfiction book, ''The Doctor Who Fooled the World,'' was published in Se ...
that he was able to cure autistic children using his own
bone marrow Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It is composed of hematopoietic ce ...
. Fudenberg was a co-inventor of the autism "treatments" Wakefield obtained a patent for in 1997, and Wakefield stated the same year in a letter to the bursary of Royal Free Hospital's School of Medicine that he was waiting on a business plan from NITRF.


Flu vaccine claims

In a 2005 episode of '' Larry King Live'' in which
Bill Maher William Maher (; born January 20, 1956) is an American comedian, writer, producer, political commentator, actor, and television host. He is known for the HBO political talk show ''Real Time with Bill Maher'' (2003–present) and the similar la ...
was being interviewed by Larry King, Maher argued that "if you have a flu shot for more than five years in a row, there's ten times the likelihood that you'll get Alzheimer's disease." This claim has been traced by
David Gorski David Henry Gorski is an American surgical oncologist, professor of surgery at Wayne State University School of Medicine, and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery. He is an out ...
back to Fudenberg; Gorski noted that it appeared on what he called an "über-crank" web-site. Specifically, it appears Fudenberg made the claim when speaking at the 1st annual International Public Conference on Vaccination, held by the
National Vaccine Information Center The National Vaccine Information Center (NVIC), founded under the name Dissatisfied Parents Together (DPT) in 1982, is an American 501(c)(3) organization that has been widely criticized as a leading source of fearmongering and misinformation a ...
in
Arlington, Virginia Arlington County is a county in the Commonwealth of Virginia. The county is situated in Northern Virginia on the southwestern bank of the Potomac River directly across from the District of Columbia, of which it was once a part. The county is ...
in 1997. The origin of the claim is unknown, as there is no study published in a peer-reviewed journal making such a claim. Furthermore, one study found that past exposure to influenza vaccines is associated with lower risk for Alzheimer's disease.


License revocation

In 1995 Fudenberg's medical license was revoked. The
Casewatch Quackwatch is a United States-based website, self-described as a "network of people" founded by Stephen Barrett, which aims to "combat health-related frauds, myths, fads, fallacies, and misconduct" and to focus on "quackery-related information tha ...
website states: "the South Carolina medical board found Fudenberg "guilty of engaging in dishonorable, unethical, or unprofessional conduct," fined him $10,000, ordered him to surrender his license to prescribe controlled substances (narcotic drugs), and placed his license on indefinite suspension." The board found that:
The Respondent admitted that he has on numerous occasions obtained controlled substances and legend drugs, namely,
prosom Estazolam, sold under the brand name Prosom among others, is a tranquilizer medication of the triazolobenzodiazepine (TBZD) class, which are benzodiazepines (BZDs) fused with a triazole ring . It possesses anxiolytic, anticonvulsant, hypnotic, ...
, ambien,
lasix Furosemide is a loop diuretic medication used to treat edema, fluid build-up due to heart failure, hepatic cirrhosis, liver scarring, or kidney disease. It may also be used for the treatment of hypertension, high blood pressure. It can be take ...
, and
potassium Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosphe ...
from a member of his office staff and others, and that he has unlawfully obtained these controlled substances for his own use, and has, in fact, used these medications.
In an interview with ''
The Post and Courier ''The Post and Courier'' is the main daily newspaper in Charleston, South Carolina. It traces its ancestry to three newspapers, the ''Charleston Courier'', founded in 1803, the ''Charleston Daily News'', founded 1865, and ''The Evening Post'', f ...
'', Fudenberg contended that "
alcohol Alcohol most commonly refers to: * Alcohol (chemistry), an organic compound in which a hydroxyl group is bound to a carbon atom * Alcohol (drug), an intoxicant found in alcoholic drinks Alcohol may also refer to: Chemicals * Ethanol, one of sev ...
and
opiate An opiate, in classical pharmacology, is a substance derived from opium. In more modern usage, the term ''opioid'' is used to designate all substances, both natural and synthetic, that bind to opioid receptors in the brain (including antagonis ...
charges are completely false" and tried to attribute many of the problems to a former staff member at NITRF.


Death

On March 15, 2014, Fudenberg died at the age of 85. He was survived by his four sons; including the economist
Drew Fudenberg Drew Fudenberg (born March 2, 1957) is a Professor of Economics at MIT. His extensive research spans many aspects of game theory, including equilibrium theory, learning in games, evolutionary game theory, and many applications to other fields. ...
.


References


External links


Neuro Immuno Therapeutics Research Foundation
homepage {{DEFAULTSORT:Fudenberg, H. Hugh 1928 births 2014 deaths American immunologists Boston University alumni University of California, San Francisco faculty Medical University of South Carolina faculty University of California, Berkeley faculty Pritzker School of Medicine alumni University of California, Los Angeles alumni American anti-vaccination activists People from Inman, South Carolina