György Buzsáki
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György Buzsáki (; born November 24, 1949, Kaposvár, Hungary) is the Biggs Professor of Neuroscience at
New York University School of Medicine NYU Grossman School of Medicine is a medical school of New York University, a private research university in New York City. It was founded in 1841 and is one of two medical schools of the university, with the other being the Long Island School of ...
.


Education

Buzsáki completed his M.D. in 1974 at the
University of Pécs The University of Pécs (UP; Hungarian: ''Pécsi Tudományegyetem''; PTE) is an institution of higher education in Hungary. The modern university was established in 1912 but has its roots in the medieval university founded in Pécs in 1367 by ...
in Hungary, and obtained his PhD in neuroscience under the supervision of Endre Grastyán.


Work

Buzsáki's primary interests is "neural syntax", i.e., how segmentation of neural information is organized by the numerous brain rhythms to support
cognitive function Cognitive skills, also called cognitive functions, cognitive abilities or cognitive capacities, are brain-based skills which are needed in acquisition of knowledge, manipulation of information and reasoning. They have more to do with the mechanisms ...
s. He identified the cellular-synaptic basis of
hippocampal The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, an ...
theta Theta (, ; uppercase: Θ or ; lowercase: θ or ; grc, ''thē̂ta'' ; Modern: ''thī́ta'' ) is the eighth letter of the Greek alphabet, derived from the Phoenician letter Teth . In the system of Greek numerals, it has a value of 9. Gr ...
, gamma oscillations and sharp waves with associated fast oscillations, their relationship to each other and to behavior and
sleep Sleep is a sedentary state of mind and body. It is characterized by altered consciousness, relatively inhibited sensory activity, reduced muscle activity and reduced interactions with surroundings. It is distinguished from wakefulness by a de ...
. He was the first to demonstrate the role of GABAergic interneurons in network oscillations. Buzsáki's recognition of the importance hierarchical organization of brain rhythms of different frequencies and their cross-frequency coupling has opened up opportunities for the dissection of cognitive mechanisms in health and disease. His most influential work, the two-stage model of memory trace consolidation, demonstrates how the
neocortex The neocortex, also called the neopallium, isocortex, or the six-layered cortex, is a set of layers of the mammalian cerebral cortex involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, sp ...
-mediated information during learning transiently modifies
hippocampal The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, an ...
networks, followed by reactivation and consolidation of these memory traces during sharp wave-ripple patterns of sleep. Buzsáki's demonstration that in the absence of changing environmental signals, cortical circuits continuously generate self-organized cell assembly sequences is an important link to the neuronal assembly basis of cognitive functions. His experiments demonstrated how skewed distribution of firing rates supports robustness, sensitivity,
plasticity Plasticity may refer to: Science * Plasticity (physics), in engineering and physics, the propensity of a solid material to undergo permanent deformation under load * Neuroplasticity, in neuroscience, how entire brain structures, and the brain it ...
and stability in neuronal networks. He has pioneered numerous technical innovations, including large-scale recording methods using silicon chips and the
NeuroGrid Neurogrid is a piece of computer hardware that is designed specifically for simulation of biological brains. It uses analog computation to emulate ion channel activity, and digital communication to softwire structured connectivity patterns. Neurog ...
, an organic, conformable electrode system used in both animal and patients.


Memberships and honors

He is a member of the National Academy of Sciences USA, Fellow of the American Association for the Advancement of Science and the Academiae Europaeae and an external member of the Hungarian Academy of Sciences. Buzsáki received honoris causa from Université Aix-Marseille, France, University of Kaposvár, Hungary and University of Pécs, Hungary. He was the winner of the inaugural Brain Prize in 2011 together with Tamás Freund and Péter Somogyi for their work describing organization of neurons in the
hippocampus The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, a ...
and the
cortex Cortex or cortical may refer to: Biology * Cortex (anatomy), the outermost layer of an organ ** Cerebral cortex, the outer layer of the vertebrate cerebrum, part of which is the ''forebrain'' *** Motor cortex, the regions of the cerebral cortex i ...
. He is the 2020 recipient of the Ralph Gerard Prize, the highest honor from the Society for Neuroscience, USA. Also in 2011 he was awarded a Senior Fellowship of the Zukunftskolleg at the
University of Konstanz The University of Konstanz (german: Universität Konstanz) is a university in the city of Konstanz in Baden-Württemberg, Germany. Its main campus was opened on the Gießberg in 1972 after being founded in 1966. The university is Germany's ...
.


Books and scientific papers

He is the author of ''Rhythms of the Brain'' (
Oxford University Press Oxford University Press (OUP) is the university press of the University of Oxford. It is the largest university press in the world, and its printing history dates back to the 1480s. Having been officially granted the legal right to print books ...
, 2006), a book detailing the current neuroscientific understanding of brain rhythms, and of more than 300 peer reviewed papers. He is among the top 1% most-cited neuroscientists ("highly cited") by
Thomson Reuters Thomson Reuters Corporation ( ) is a Canadian multinational media conglomerate. The company was founded in Toronto, Ontario, Canada, where it is headquartered at the Bay Adelaide Centre. Thomson Reuters was created by the Thomson Corpora ...
. He has released a book titled ''The Brain from Inside Out'' in 2019, which proposes a new framework of thinking of the brain as an explorer constantly controlling the body to test hypotheses and not as an information absorbing coding device.


Selected works

*Buzsáki, G. (2019). ''The Brain From Inside Out''. New York: Oxford University Press. * *Buzsaki, G. (2006). ''Rhythms of the Brain''. New York: Oxford University Press. *Buzsáki, G., & Draguhn, A. (2004). Neuronal oscillations in cortical networks. ''Science'', 304(5679), 1926-1929. * *


References


External links


Buzsaki Lab web page

Google Scholar citations
{{DEFAULTSORT:Buzsaki, Gyorgy 1949 births Hungarian neuroscientists Hungarian scientists Living people