Guido Banti
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Guido Banti (8 June 1852 – 8 January 1925) was an Italian
physician A physician (American English), medical practitioner (Commonwealth English), medical doctor, or simply doctor, is a health professional who practices medicine, which is concerned with promoting, maintaining or restoring health through th ...
and
pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...
. He also performed innovative studies on the heart, infectious diseases and
bacteriology Bacteriology is the branch and specialty of biology that studies the morphology, ecology, genetics and biochemistry of bacteria as well as many other aspects related to them. This subdivision of microbiology involves the identification, classificat ...
,
splenomegaly Splenomegaly is an enlargement of the spleen. The spleen usually lies in the left upper quadrant (LUQ) of the human abdomen. Splenomegaly is one of the four cardinal signs of ''hypersplenism'' which include: some reduction in number of circulating ...
,
nephrology Nephrology (from Greek'' nephros'' "kidney", combined with the suffix ''-logy'', "the study of") is a specialty of adult internal medicine and pediatric medicine that concerns the study of the kidneys, specifically normal kidney function (ren ...
, lung disease,
leukaemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
and
motor aphasia Expressive aphasia, also known as Broca's aphasia, is a type of aphasia characterized by partial loss of the ability to produce language ( spoken, manual, or written), although comprehension generally remains intact. A person with expressive aphas ...
. He gave his name to Banti’s disease.


Biography

Banti was born in Montebichieri in
Tuscany Tuscany ( ; it, Toscana ) is a Regions of Italy, region in central Italy with an area of about and a population of about 3.8 million inhabitants. The regional capital is Florence (''Firenze''). Tuscany is known for its landscapes, history, art ...
. His father was a physician. He studied medicine at the
University of Pisa The University of Pisa ( it, Università di Pisa, UniPi), officially founded in 1343, is one of the oldest universities in Europe. History The Origins The University of Pisa was officially founded in 1343, although various scholars place ...
and later the Medical School in
Florence Florence ( ; it, Firenze ) is a city in Central Italy and the capital city of the Tuscany region. It is the most populated city in Tuscany, with 383,083 inhabitants in 2016, and over 1,520,000 in its metropolitan area.Bilancio demografico an ...
where he graduated in 1877. He was appointed to an assistant’s position at the local
Hospital of Santa Maria Nuova The Hospital of Santa Maria Nuova (i.e. ''Ospedale di Santa Maria Nuova'' in Italian) is the oldest hospital still active in Florence, Italy. History and artistic profile Origins The hospital was founded in 1288 by Folco Portinari, the father ...
and concurrently, as an assistant at the Laboratory of Pathological Anatomy. The ability to observe patients in bed and then carry out post mortem examination was to prove fundamental in parts of his work. Working under the guidance of Celso Pellizzari by 1882 he was chief of medical services. In 1895, after a 5-year spell in a temporary post, he was appointed Ordinary Professor of Pathological Anatomy in the medical school in Florence. He remained in this post for 29 years until his retirement and death a year later in 1925.


Work

Banti’s lifetime’s work ranged across several specialties. He published the first textbook in Italy on the techniques of bacteriology; ''Manuale di Tecnica Batteriologica,'' (Florence, 1885). In 1886, he undertook a study of heart enlargement, and at the same time as an
anatomist Anatomy () is the branch of biology concerned with the study of the structure of organisms and their parts. Anatomy is a branch of natural science that deals with the structural organization of living things. It is an old science, having its ...
he studied the causes of
aphasia Aphasia is an inability to comprehend or formulate language because of damage to specific brain regions. The major causes are stroke and head trauma; prevalence is hard to determine but aphasia due to stroke is estimated to be 0.1–0.4% in th ...
, confuting the contemporary theory of
Pierre Marie Pierre Marie (9 September 1853 – 13 April 1940) was a French neurologist and political journalist close to the SFIO. Medical Career After finishing medical school, he served as an interne (1878), working as an assistant to neurologist Jean- ...
with a publication ''A proposito de recenti sulle afasie'' (Florence, 1907), followed in 1898 by a study of hyperplastic
gastritis Gastritis is inflammation of the lining of the stomach. It may occur as a short episode or may be of a long duration. There may be no symptoms but, when symptoms are present, the most common is upper abdominal pain (see dyspepsia). Other possi ...
. He spent time studying cancer cells in 1890–93. 1894 he published a study of
typhoid fever Typhoid fever, also known as typhoid, is a disease caused by '' Salmonella'' serotype Typhi bacteria. Symptoms vary from mild to severe, and usually begin six to 30 days after exposure. Often there is a gradual onset of a high fever over several ...
, ''Le setticemie tifiche'' (Florence). In 1895 he wrote about
endocarditis Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the ...
and
nephritis Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue surrounding the glomeruli and tubules. It is one of several different types of nephropathy. Types * Glomerulonephritis is inflammation of th ...
, ''Endocarditis e nefriti''. (Florence) describing various forms of endocarditis and
atherosclerosis Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheroma, atheromatous plaque. At onset there are usu ...
of the
kidney The kidneys are two reddish-brown bean-shaped organs found in vertebrates. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood ...
. From 1882 to 1914 he studied various forms of splenomegaly, enlargement of the spleen, with neither infection nor degeneration. He described one form that was characterized by progressive
anaemia Anemia or anaemia (British English) is a blood disorder in which the blood has a reduced ability to carry oxygen due to a lower than normal number of red blood cells, or a reduction in the amount of hemoglobin. When anemia comes on slowly, th ...
in adults, and from his earliest studies he described a new form of enlarged spleen which led to
cirrhosis Cirrhosis, also known as liver cirrhosis or hepatic cirrhosis, and end-stage liver disease, is the impaired liver function caused by the formation of scar tissue known as fibrosis due to damage caused by liver disease. Damage causes tissue repai ...
of the liver with
ascites Ascites is the abnormal build-up of fluid in the abdomen. Technically, it is more than 25 ml of fluid in the peritoneal cavity, although volumes greater than one liter may occur. Symptoms may include increased abdominal size, increased weight, ab ...
and eventual death. This work resulted in two papers, ''Dell’anemia splenica'' and ''Archivo di anatomica patologica'' (1882) describing the condition that would be known as Banti’s disease. Banti proposed that the enlarged spleen was the cause of red cell destruction which led to anemia and that only removal of the spleen could stop this process. On his advice the first
splenectomy A splenectomy is the surgical procedure that partially or completely removes the spleen. The spleen is an important organ in regard to immunological function due to its ability to efficiently destroy encapsulated bacteria. Therefore, removal of ...
for haemolytic jaundice was carried out in Florence in 1903. Banti’s name is associated closely with leukaemia. He asserted in 1903 that “All leukaemias belong to the
sarcoma A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sarcom ...
toses”, this was contrary to the existing opinions of
Artur Pappenheim Artur Pappenheim (13 December 1870 in Berlin – 31 December 1916) was a German physician and hematologist, remembered for his pioneer efforts in stem cell research. Biography Of Jewish origins, initially he studied mathematics and philosophy, b ...
and Carl von Sternberg. Banti continued with further observations and in 1913 decided that the leukaemias are systematic diseases arising from the haemopoietic structures,
bone marrow Bone marrow is a semi-solid tissue found within the spongy (also known as cancellous) portions of bones. In birds and mammals, bone marrow is the primary site of new blood cell production (or haematopoiesis). It is composed of hematopoietic ce ...
and
lymph glands A lymph node, or lymph gland, is a kidney-shaped organ of the lymphatic system and the adaptive immune system. A large number of lymph nodes are linked throughout the body by the lymphatic vessels. They are major sites of lymphocytes that include ...
, and that they are the result of the uncontrolled proliferation of staminal blood cells. This definition accords closely with the modern definition. Banti was a municipal advisor and consultant to the sanitary services in Florence from 1907 to 1909.


References


External links


English translation of Italian Encyclopedia
{{DEFAULTSORT:Banti, Guido 19th-century Italian physicians 1852 births 1925 deaths 20th-century Italian physicians Italian healthcare managers