Glutamate-5-semialdehyde is a non-proteinogenic amino acid involved in both the biosynthesis and degradation of
proline
Proline (symbol Pro or P) is an organic acid classed as a proteinogenic amino acid (used in the biosynthesis of proteins), although it does not contain the amino group but is rather a secondary amine. The secondary amine nitrogen is in the prot ...
and
arginine
Arginine is the amino acid with the formula (H2N)(HN)CN(H)(CH2)3CH(NH2)CO2H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO2−) and both the am ...
(via
ornithine
Ornithine is a non-proteinogenic amino acid that plays a role in the urea cycle. Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency. The radical is ornithyl.
Role in urea cycle
L-Ornithine is one of the produ ...
),
as well as in the biosynthesis of antibiotics, such as
carbapenem
Carbapenems are a class of very effective antibiotic agents most commonly used for the treatment of severe bacterial infections. This class of antibiotics is usually reserved for known or suspected multidrug-resistant (MDR) bacterial infections. ...
s. It is synthesized by the reduction of
glutamyl-5-phosphate by
glutamate-5-semialdehyde dehydrogenase
In enzymology, a glutamate-5-semialdehyde dehydrogenase () is an enzyme that catalyzes the chemical reaction
:L-glutamate 5-semialdehyde + phosphate + NADP+ \rightleftharpoons L-glutamyl 5-phosphate + NADPH + H+
The 3 substrates of this enzyme ...
.
See also
*
Glutamate-1-semialdehyde
Glutamate-1-semialdehyde is a molecule formed from by the reduction of tRNA bound glutamate, catalyzed by glutamyl-tRNA reductase. It is isomerized by glutamate-1-semialdehyde 2,1-aminomutase to give aminolevulinic acid in the biosynthesis of por ...
References
{{Amino acid metabolism intermediates
Amino acids
Aldehydes
Aldehydic acids