Giuseppe Sanarelli (24 September 1865 – 6 April 1940) was an Italian bacteriologist who incorrectly identified the cause of

yellow fever Yellow fever is a viral disease of typically short duration. In most cases, symptoms include fever, chills, loss of appetite, nausea, muscle pains – particularly in the back – and headaches. Symptoms typically improve within five days. In ...

as a

bacterium Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...

. It was however found later by

Walter Reed Walter Reed (September 13, 1851 – November 22, 1902) was a U.S. Army physician who in 1901 led the team that confirmed the theory of Cuban doctor Carlos Finlay that yellow fever is transmitted by a particular mosquito species rather than b ...

that the bacterium ''Bacillus icterioides'' was a secondary infection. In 1897 he triggered the first major public debate on medical ethics when he injected yellow fever bacteria into five patients without consent, three of whom died. He also served as a senator of the Kingdom of Italy from 1920 to 1940.

Life and work

Sanarelli was born at

Monte San Savino Monte San Savino is a town and comune in the province of Arezzo, Tuscany (Italy). It is located on the Essa stream in the Valdichiana. Several of its frazioni occupy higher hills, like Gargonza at and Palazzuolo, at an elevation of . History M ...

Arezzo Arezzo ( , , ) , also ; ett, 𐌀𐌓𐌉𐌕𐌉𐌌, Aritim. is a city and ''comune'' in Italy and the capital of the province of the same name located in Tuscany. Arezzo is about southeast of Florence at an elevation of above sea level. ...

to Guglielmo and Veniglia Veltroni Poderetti. He studied medicine at the Universities of Siena and

Pavia Pavia (, , , ; la, Ticinum; Medieval Latin: ) is a town and comune of south-western Lombardy in northern Italy, south of Milan on the lower Ticino river near its confluence with the Po. It has a population of c. 73,086. The city was the capit ...

, working under

Camillo Golgi Camillo Golgi (; 7 July 184321 January 1926) was an Italian biologist and pathologist known for his works on the central nervous system. He studied medicine at the University of Pavia (where he later spent most of his professional career) betwee ...

. He then studied under Max Pettenkofer in Munich and in 1892 under

Louis Pasteur Louis Pasteur (, ; 27 December 1822 – 28 September 1895) was a French chemist and microbiologist renowned for his discoveries of the principles of vaccination, microbial fermentation and pasteurization, the latter of which was named afte ...

Emile Roux Emil or Emile may refer to: Literature *''Emile, or On Education'' (1762), a treatise on education by Jean-Jacques Rousseau * ''Émile'' (novel) (1827), an autobiographical novel based on Émile de Girardin's early life *''Emil and the Detective ...

and

Ilya Metchnikoff Ilya, Iliya, Ilia, Ilja, or Ilija (russian: Илья́, Il'ja, , or russian: Илия́, Ilija, ; uk, Ілля́, Illia, ; be, Ілья́, Iĺja ) is the East Slavic form of the male Hebrew name Eliyahu (Eliahu), meaning "My God is Yahu/ Jah." ...

at Paris on cholera. He became a professor of pathology at Siena in 1889. In 1896 he moved to

Montevideo Montevideo () is the Capital city, capital and List of cities in Uruguay, largest city of Uruguay. According to the 2011 census, the city proper has a population of 1,319,108 (about one-third of the country's total population) in an area of . M ...

, Uruguay to head a newly founded hygiene institution. His studies on pathogenesis led to the identification of rabbit

myxomatosis Myxomatosis is a disease caused by ''Myxoma virus'', a poxvirus in the genus ''Leporipoxvirus''. The natural hosts are tapeti (''Sylvilagus brasiliensis'') in South and Central America, and brush rabbits (''Sylvilagus bachmani'') in North Ame ...

, caused by a filterable agent that Benjamin Lipschütz named as ''Sanarellia cuniculi'' in 1927. In 1897, while studying yellow fever, he injected bacterial preparations into five patients without their consent. Three of them died, and this led to a major debate on medical ethics led mainly by

William Osler Sir William Osler, 1st Baronet, (; July 12, 1849 – December 29, 1919) was a Canadian physician and one of the "Big Four" founding professors of Johns Hopkins Hospital. Osler created the first Residency (medicine), residency program for spec ...

. Sanarelli noted that bacteria injected intravenously could result in severe hemorrhage. Gregory Shwartzman found that just the toxins of bacteria could cause a similar reaction and since the reactions are similar, the term Sanarelli-

Shwartzman phenomenon Shwartzman phenomenon is a rare reaction of a body to particular types of toxins, called endotoxins, which cause thrombosis in the affected tissue. A clearing of the thrombosis results in a reticuloendothelial blockade, which prevents re-clearin ...

has been used. This is a known risk in certain forms of vaccines injected intravenously but more generic terms like

Disseminated intravascular coagulation Disseminated intravascular coagulation (DIC) is a condition in which blood clots form throughout the body, blocking small blood vessels. Symptoms may include chest pain, shortness of breath, leg pain, problems speaking, or problems moving parts o ...

and

cytokine storm A cytokine storm, also called hypercytokinemia, is a physiological reaction in humans and other animals in which the innate immune system causes an uncontrolled and excessive release of pro-inflammatory signaling molecules called cytokines. Norma ...

have largely replaced the term. Sanarelli married Maria Carmen Pons in Montevideo in 1898. In 1901, he became chair of hygiene at the

University of Bologna The University of Bologna ( it, Alma Mater Studiorum – Università di Bologna, UNIBO) is a public research university in Bologna, Italy. Founded in 1088 by an organised guild of students (''studiorum''), it is the oldest university in continuo ...

. He served in the Ministry of Agriculture, Industry and Commerce from 1906 to 1909 dealing with issues related to colonialism, the colonies, and diseases. In 1915 he moved to the University of Rome and became a rector of the University in 1922. He became a senator to the Kingdom of Italy in 1920 and became politically active, opposing reforms and standing in defense of anti-fascist students in 1925 and later signed the manifesto of anti-fascist intellectuals. He however became less active and later limited himself to not joining the fascist party. He died in 1940 at Rome from appendicitis.

References

{{DEFAULTSORT:Sanarelli, Giuseppe Italian bacteriologists 1865 births 1940 deaths Anti-fascists People from Monte San Savino