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Myxomatosis
Myxomatosis is a disease caused by ''Myxoma virus'', a poxvirus in the genus ''Leporipoxvirus''. The natural hosts are tapeti (''Sylvilagus brasiliensis'') in South and Central America, and brush rabbits (''Sylvilagus bachmani'') in North America. The myxoma virus causes only a mild disease in these species, but causes a severe and usually fatal disease in European rabbits (''Oryctolagus cuniculus''). Myxomatosis is an excellent example of what occurs when a virus jumps from a species adapted to it to a naive host, and has been extensively studied for this reason. The virus was intentionally introduced in Australia, France, and Chile in the 1950s to control wild European rabbit populations. Cause ''Myxoma virus'' is in the genus ''Leporipoxvirus'' (family ''Poxviridae''; subfamily ''Chordopoxvirinae''). Like other poxviruses, myxoma viruses are large DNA viruses with linear double-stranded DNA. Virus replication occurs in the cytoplasm of the cell. The natural hosts are tapet ...
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Myxomatosis In A Pet Rabbit
Myxomatosis is a disease caused by ''Myxoma virus'', a poxvirus ''Poxviridae'' is a family of double-stranded DNA viruses. Vertebrates and arthropods serve as natural hosts. There are currently 83 species in this family, divided among 22 genera, which are divided into two subfamilies. Diseases associated wit ... in the genus ''Leporipoxvirus''. The natural hosts are tapeti (''Sylvilagus brasiliensis'') in South and Central America, and brush rabbits (''Sylvilagus bachmani'') in North America. The myxoma virus causes only a mild disease in these species, but causes a severe and usually fatal disease in European rabbits (''Oryctolagus cuniculus''). Myxomatosis is an excellent example of what occurs when a virus jumps from a species adapted to it to a naive host, and has been extensively studied for this reason. The virus was intentionally introduced in Australia, France, and Chile in the 1950s to control wild European rabbit populations. Cause ''Myxoma virus'' is in the genu ...
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European Rabbit
The European rabbit (''Oryctolagus cuniculus'') or coney is a species of rabbit native to the Iberian Peninsula (including Spain, Portugal, and southwestern France), western France, and the northern Atlas Mountains in northwest Africa. It has been widely introduced elsewhere, often with devastating effects on local biodiversity. Its decline in its native range due to myxomatosis, rabbit calicivirus, overhunting and habitat loss has caused the decline of the Iberian lynx (''Lynx pardinus'') and Spanish imperial eagle (''Aquila adalberti''). It is known as an invasive species because it has been introduced to countries on all continents with the exception of Antarctica, and has caused many problems within the environment and ecosystems; in particular, European rabbits in Australia have had a devastating impact, due in part to the lack of natural predators there. The European rabbit is well known for digging networks of burrows, called warrens, where it spends most of its tim ...
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Rabbit With Myxomatosis 1(RLH)
Rabbits, also known as bunnies or bunny rabbits, are small mammals in the family Leporidae (which also contains the hares) of the order Lagomorpha (which also contains the pikas). ''Oryctolagus cuniculus'' includes the European rabbit species and its descendants, the world's 305 breeds of domestic rabbit. ''Sylvilagus'' includes 13 wild rabbit species, among them the seven types of cottontail. The European rabbit, which has been introduced on every continent except Antarctica, is familiar throughout the world as a wild prey animal and as a domesticated form of livestock and pet. With its widespread effect on ecologies and cultures, the rabbit is, in many areas of the world, a part of daily life—as food, clothing, a companion, and a source of artistic inspiration. Although once considered rodents, lagomorphs like rabbits have been discovered to have diverged separately and earlier than their rodent cousins and have a number of traits rodents lack, like two extra incisors ...
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Myxoma Virus
''Myxoma virus'' is a poxvirus in the genus ''Leporipoxvirus''. The two broad geographic types of ''myxoma virus'' are Californian and South American. Californian ''myxoma virus'' is found on the West Coast of the United States, the Baja Peninsula of Mexico, and the southwest coast of Canada. South American or Brazilian ''myxoma virus'' is found in South and Central America. South American'' myxoma virus ''circulates in the jungle rabbit or tapeti (''Sylvilagus brasiliensis''), whereas Californian ''myxoma virus'' circulates in the brush rabbit (''Sylvilagus bachmani''). In their native hosts, the viruses cause the formation of benign cutaneous fibromas rather than systemic disease. Transmission ''Myxoma virus'' is passively transmitted on the mouth parts of mosquitoes, (such as '' Aedes aegyptii'') or fleas, and presumably other biting arthropods. It can also be spread through direct contact and contaminated fomites. Myxomatosis Myxomatosis is the name of the lethal dissemina ...
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Leporipoxvirus
''Leporipoxvirus'' is a genus of viruses, in the family ''Poxviridae'', in the subfamily ''Chordopoxvirinae''. Lagomorphs and squirrels serve as natural hosts. There are four species in this genus. Diseases associated with this genus include: myxomatosis. Taxonomy The genus contains the following species: * '' Hare fibroma virus'' * ''Myxoma virus ''Myxoma virus'' is a poxvirus in the genus ''Leporipoxvirus''. The two broad geographic types of ''myxoma virus'' are Californian and South American. Californian ''myxoma virus'' is found on the West Coast of the United States, the Baja Penins ...'' * '' Rabbit fibroma virus'' * '' Squirrel fibroma virus'' Structure Viruses in ''Leporipoxvirus'' are enveloped, with brick-shaped geometries. Genomes are linear, around 160kb in length. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the h ...
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Tapeti
The common tapeti (''Sylvilagus brasiliensis''), also known as the Brazilian cottontail, forest cottontail, or (formerly) simply tapeti is a species of cottontail rabbit. It is small to medium-sized with a small, dark tail, short hind feet, and short ears. As traditionally defined, its range extends from southern Mexico to northern Argentina, but this includes several distinctive population that have since been split into separate species. Under this narrower definition, the true tapeti only occurs in the Atlantic Rainforest of coastal northeastern Brazil and it is classified as "Endangered" by the IUCN. The American Society of Mammalogists concurs, but also tentatively classifies several distinct populations that have not yet received proper species names into ''S. brasiliensis'', and thus considers it to range from Venezuela south to Argentina. Taxonomy The species was first described scientifically by Carl Linnaeus in the 10th edition of Systema Naturae, published in 1753. Th ...
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Brush Rabbits
The brush rabbit (''Sylvilagus bachmani''), or western brush rabbit, or Californian brush rabbit, is a species of cottontail rabbit found in western coastal regions of North America, from the Columbia River in Oregon to the southern tip of the Baja California Peninsula. Its range extends as far east as the eastern sides of the Sierra Nevada and Cascade mountain ranges. Description and taxonomy The brush rabbit is a small rabbit with short legs and a short tail. It is dark gray on the sides and back, and pale gray on the belly and the underside of the tail. The whiskers are mostly black, although some have white tips. Adult rabbits measure anywhere from in length, and range in weight from . Large numbers of geographically defined subspecies have been proposed, including in Oregon, ''ubericolor''; in California, ''cinerascens'', ''mariposae'', ''riparius'', ''tehamae'' and ''trowbridgii''; and in Baja California, ''cerrosensis'', ''exiguus'', ''howelli'', ''peninsularis'' and ...
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Necropsy
An autopsy (post-mortem examination, obduction, necropsy, or autopsia cadaverum) is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any disease or injury that may be present for research or educational purposes. (The term "necropsy" is generally reserved for non-human animals). Autopsies are usually performed by a specialized medical doctor called a pathologist. In most cases, a medical examiner or coroner can determine the cause of death. However, only a small portion of deaths require an autopsy to be performed, under certain circumstances. Purposes of performance Autopsies are performed for either legal or medical purposes. Autopsies can be performed when any of the following information is desired: * Determine if death was natural or unnatural * Injury source and extent on the corpse * Manner of death must be determined * Post mortem interval * Determining the decease ...
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Purulent
Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during bacterial or fungal infection. An accumulation of pus in an enclosed tissue space is known as an abscess, whereas a visible collection of pus within or beneath the epidermis is known as a pustule, pimple or ''spot''. Description Pus consists of a thin, protein-rich fluid (historically known as ''liquor puris'') and dead leukocytes from the body's immune response (mostly neutrophils). During infection, macrophages release cytokines, which trigger neutrophils to seek the site of infection by chemotaxis. There, the neutrophils release granules, which destroy the bacteria. The bacteria resist the immune response by releasing toxins called leukocidins.Madigan, Michael T. and Martin, John M. Brock Biology of Microorganisms 11th ed. Pearson Prentice Hall. US. 2006: 734 As the neutrophils die off from toxins and old age, they are destroyed by macrophages, forming the viscous ...
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Blepharoconjunctivitis
Conjunctivitis, also known as pink eye, is inflammation of the outermost layer of the white part of the eye and the inner surface of the eyelid. It makes the eye appear pink or reddish. Pain, burning, scratchiness, or itchiness may occur. The affected eye may have increased tears or be "stuck shut" in the morning. Swelling of the white part of the eye may also occur. Itching is more common in cases due to allergies. Conjunctivitis can affect one or both eyes. The most common infectious causes are viral followed by bacterial. The viral infection may occur along with other symptoms of a common cold. Both viral and bacterial cases are easily spread between people. Allergies to pollen or animal hair are also a common cause. Diagnosis is often based on signs and symptoms. Occasionally, a sample of the discharge is sent for culture. Prevention is partly by handwashing. Treatment depends on the underlying cause. In the majority of viral cases, there is no specific treatment. Most ...
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Histopathology
Histopathology (compound of three Greek words: ''histos'' "tissue", πάθος ''pathos'' "suffering", and -λογία '' -logia'' "study of") refers to the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or surgical specimen by a pathologist, after the specimen has been processed and histological sections have been placed onto glass slides. In contrast, cytopathology examines free cells or tissue micro-fragments (as "cell blocks"). Collection of tissues Histopathological examination of tissues starts with surgery, biopsy, or autopsy. The tissue is removed from the body or plant, and then, often following expert dissection in the fresh state, placed in a fixative which stabilizes the tissues to prevent decay. The most common fixative is 10% neutral buffered formalin (corresponding to 3.7% w/v formaldehyde in neutral buffered water, such as phosphate buf ...
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Virus Isolation
Viral culture is a laboratory technique in which samples of a virus are placed to different cell lines which the virus being tested for its ability to infect. If the cells show changes, known as cytopathic effects, then the culture is positive. Traditional viral culture has been generally superseded by shell vial culture, in which the sample is centrifuged onto a single layer of cells and viral growth is measured by antigen detection methods. This greatly reduces the time to detection for slow growing viruses such as cytomegalovirus, for which the method was developed. In addition, the centrifugation step in shell vial culture enhances the sensitivity of this method because after centrifugation, the viral particles of the sample are in close proximity to the cells. Human and monkey cells are used in both traditional viral culture and shell vial culture. Human virus types that can be identified by viral culture include adenovirus, cytomegalovirus, enteroviruses, herpes simp ...
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