George Quentin Daley is the Dean of the Faculty of Medicine, Caroline Shields Walker Professor of Medicine, and Professor of Biological Chemistry and Molecular Pharmacology at

Harvard Medical School Harvard Medical School (HMS) is the graduate medical school of Harvard University and is located in the Longwood Medical Area of Boston, Massachusetts. Founded in 1782, HMS is one of the oldest medical schools in the United States and is consi ...

. He was formerly the Robert A. Stranahan Professor of Pediatrics at Harvard Medical School, Director of the Stem Cell Transplantation Program at

Boston Children's Hospital Boston Children's Hospital formerly known as Children's Hospital Boston until 2012 is a nationally ranked, freestanding acute care children's hospital located in Boston, Massachusetts, adjacent both to its teaching affiliate, Harvard Medical Scho ...

, and an investigator of the Howard Hughes Medical Institute,Investigators, Howard Hughes Medical Institut

Retrieved 2010-08-30. Associate Director of Children's Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute.Principal Faculty, Harvard Stem Cell Institut

Retrieved 2010-08-30. He is a past president of the International Society for Stem Cell Research (2007–2008).Officers, Leadership, International Society for Stem Cell Researc

Retrieved 2010-08-30.

Early life and education

Daley was born in

Catskill, New York Catskill is a town in the southeastern section of Greene County, New York, United States. The population was 11,298 at the 2020 census, the largest town in the county. The western part of the town is in the Catskill Park. The town contains a v ...

. Daley received his Bachelor of Arts ''magna cum laude'' from

Harvard College Harvard College is the undergraduate college of Harvard University, an Ivy League research university in Cambridge, Massachusetts. Founded in 1636, Harvard College is the original school of Harvard University, the oldest institution of higher lea ...

(1982), his PhD in

biology Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary i ...

from

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the m ...

(1989), and his MD from

, where he was the twelfth individual in the school's history to be awarded the degree ''summa cum laude'' (1991). He served as Chief Resident in Internal Medicine at the Massachusetts General Hospital and is currently a staff physician in Hematology/Oncology at

and

Dana–Farber Cancer Institute Dana–Farber Cancer Institute is a comprehensive cancer treatment and research institution in Boston, Massachusetts. Dana–Farber is the founding member of Dana–Farber/Harvard Cancer Center, Harvard's Comprehensive Cancer Center designated by ...

.Specialists, Children's Hospital Bosto

Retrieved 2010-08-30. As a graduate student working with Nobelist Dr.

David Baltimore David Baltimore (born March 7, 1938) is an American biologist, university administrator, and 1975 Nobel laureate in Physiology or Medicine. He is President Emeritus and Distinguished Professor of Biology at the California Institute of Technol ...

, Dr. Daley demonstrated that the BCR/ABL oncogene induces

chronic myeloid leukemia Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells. It is a form of leukemia characterized by the increased and unregulated growth of myeloid cells in the bone marrow and the accumulati ...

(CML) in a mouse model,DALEY ''et al.'', SCIENCE 1990 which validated BCR/ABL as a target for drug blockade and encouraged the development of imatinib (Gleevec; Novartis), a magic-bullet chemotherapy that induces remissions in virtually every CML patient. Daley's studies have clarified mechanisms of Gleevec resistance and informed novel combination chemotherapeutic regimens.

Research

Daley's research seeks to translate insights in stem cell biology into improved therapies for genetic and malignant diseases. His laboratory has pioneered human cell culture-based and murine models of human blood disease and cancer.Biography, Stem Cell Program Leadership, Children's Hospital Bosto

Retrieved 2010-08-30. Important research contributions from his laboratory include the creation of customized stem cells to treat genetic immune deficiency in a mouse model (together with

Rudolf Jaenisch Rudolf Jaenisch (born April 22, 1942) is a Professor of Biology at MIT and a founding member of the Whitehead Institute for Biomedical Research. He is a pioneer of transgenic science, in which an animal’s genetic makeup is altered. Jaenisch ...

),RIDEOUT ET AL, CELL 2002 the differentiation of germ cells from embryonic stem cells (cited as a "Top Ten Breakthrough" by ''

Science Science is a systematic endeavor that Scientific method, builds and organizes knowledge in the form of Testability, testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earli ...

'' in 2003),Biography, 2004 Recipients, NIH Director's Pioneer Awar

Retrieved 2010-08-30.GEIJSEN ET AL., NATURE 2003/4 the generation of disease-specific pluripotent stem cells by direct reprogramming of human fibroblasts (cited in the "Breakthrough of the Year" issue of ''Science'' magazine in 2008),Bios, Team, MPM Capita

Retrieved 2010-08-30.PARK ET AL, CELL 2008 and demonstration of the role of the RNA-binding protein Lin28 in cancer and metabolic disease. He has been elected a fellow of the American Association for the Advancement of Science and the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

, and a member of the

Institute of Medicine of the National Academies The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...

American Society for Clinical Investigation The American Society for Clinical Investigation (ASCI), established in 1908, is one of the oldest and most respected medical honor societies in the United States. Organization and purpose The ASCI is an honorary society to which more than 2,800 ph ...

, American Association of Physicians and American Pediatric Societies. Daley was an inaugural winner of the NIH Director's Pioneer Award (2004), which provides a five-year unrestricted grant to pursue highly innovative research, and received the Judson Daland Prize from the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

for achievement in patient-oriented research,Recipients of the Judson Daland Prize, American Philosophical Societ

Retrieved 2010-08-30. the E. Mead Johnson Award from the

American Pediatric Society The American Pediatric Society (APS) is the first pediatric society established in North America. Created in 1888, the APS pursues a vision of an engaged, inclusive, and impactful community of pediatric thought leaders. The APS mission is to sha ...

for contributions to stem cell research,Member Information, Society for Pediatric Researc

Retrieved 2010-08-30. and the E. Donnall Thomas Prize from the

American Society of Hematology The American Society of Hematology (ASH) is a professional organization representing hematologists. It was founded in 1958. Its annual meeting is held in December of every year and has attracted more than 30,000 attendees. The society publishes t ...

for advances in induced pluripotent stem cell research, in addition to awards recognizing his contributions to medical research from the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late ...

,Meet the Scientists, National Heart Lunch and Blood Institute, National Institutes of Healt

Retrieved 2010-08-30. the New England Cancer Society, Harvard Medical School, and the Leukemia and Lymphoma Society of America. In addition to funding by the NIH, Dr. Daley's research has been supported by the National Science Foundation, Defense Advanced Research Projects Agency, American Cancer Society, Edward Mallinckrodt Jr. Foundation,

Burroughs Wellcome Fund The Burroughs Wellcome Fund (BWF) is an American non-profit medical research organization that provides funding for biomedical research, STEM education, and areas of career development for scientists. Since 1970, it has been headquartered in Nor ...

, Leukemia and Lymphoma Society of America, Roche Foundation for Anemia Research,

Alex's Lemonade Stand Alex's Lemonade Stand Foundation (previously known as Alex's Lemonade Stand and currently abbreviated as ALSF) is an American pediatric cancer charity founded by Alexandra "Alex" Scott (January 18, 1996 – August 1, 2004), who lived in Connecticu ...

, Ellison Medical Foundation, and Doris Duke Medical Foundation. Daley has been prominent in advocating for ethical oversight of human stem cell research. On behalf of the International Society for Stem Cell Research (ISSCR), he chaired the special international task force that formulated the ISSCR Guidelines for Human Embryonic Stem Cell Research (2006) and as president of the ISSCR empaneled and served on the special task force that wrote the ISSCR Guidelines for Clinical Translation of Stem Cells (2008),Information for Scientists, ISSCR Retrieved 2010-08-30. which have served as a roadmap for advancing stem cell science into clinical trials. Dr. Daley has testified six times before committees of the

United States Senate The United States Senate is the upper chamber of the United States Congress, with the House of Representatives being the lower chamber. Together they compose the national bicameral legislature of the United States. The composition and pow ...

and

United States House of Representatives The United States House of Representatives, often referred to as the House of Representatives, the U.S. House, or simply the House, is the lower chamber of the United States Congress, with the Senate being the upper chamber. Together they ...

to advocate for expanded governmental support for stem cell research. He has served on the scientific advisory board of the Massachusetts Life Sciences Center and on the editorial board of the journals ''Science'', ''Cell'', ''Cell Stem Cell'', ''Stem Cells'', and ''Blood''.

References

{{DEFAULTSORT:Daley, George Q. Scientists from New York (state) Harvard Medical School alumni Massachusetts Institute of Technology School of Science alumni Harvard Medical School faculty Living people Howard Hughes Medical Investigators Fellows of the American Academy of Arts and Sciences Year of birth missing (living people) Place of birth missing (living people) People from Boston Fellows of the AACR Academy Members of the National Academy of Medicine