The Genome Project - Write (also known as GP-Write) is a large-scale collaborative research project (an extension of

Genome Project Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus) and to annotate protein-coding genes and o ...

s, aimed at reading genomes since 1984) that focuses on the development of technologies for the synthesis and testing of genomes of many different species of microbes, plants, and animals, including the

human genome The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the ...

in a sub-project known as Human Genome Project-Write (HGP-Write). Formally announced on 2 June 2016, the project leverages two decades of work on

synthetic biology Synthetic biology (SynBio) is a multidisciplinary area of research that seeks to create new biological parts, devices, and systems, or to redesign systems that are already found in nature. It is a branch of science that encompasses a broad ran ...

and

artificial gene synthesis Artificial gene synthesis, or simply gene synthesis, refers to a group of methods that are used in synthetic biology to construct and assemble genes from nucleotides '' de novo''. Unlike DNA synthesis in living cells, artificial gene synthesis d ...

. The newly created GP-Write project will be managed by the Center of Excellence for Engineering Biology, an American nonprofit organization. Researchers expect that the ability to artificially synthesize large portions of many genomes will result in many scientific and medical advances.

Microbial Genome Projects - Write

Technologies for constructing and testing yeast artificial chromosomes (YACs), synthetic yeast genomes (Sc2.0), and virus/phage-resistant bacterial genomes have industrial, agricultural, and medical applications.

Human Genome Project-Write

A complete haploid copy of the human genome consists of at least three billion DNA

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecule ...

base pairs, which have been described in the Human Genome Project - Read program (95% completed as of 2004). Among the many goals of GP-Write are the making of cell lines resistant to all viruses and synthesis assembly lines to test

variants of unknown significance A variant of uncertain (or unknown) significance (VUS) is a genetic variant that has been identified through genetic testing but whose significance to the function or health of an organism is not known. Two related terms are "gene of uncertain sign ...

that arise in research and diagnostic sequencing of human genomes (which has been exponentially improving in cost, quality, and interpretation).

Microbial Genome Projects - Write

Human Genome Project-Write

See also

References

Further reading