''Gemella'' is a genus of

Gram-positive In bacteriology, gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their type of cell wall. Gram-positive bacte ...

bacteria Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell. They constitute a large domain of prokaryotic microorganisms. Typically a few micrometres in length, bacteria were among ...

that thrive best at high

partial pressure In a mixture of gases, each constituent gas has a partial pressure which is the notional pressure of that constituent gas as if it alone occupied the entire volume of the original mixture at the same temperature. The total pressure of an ideal gas ...

of CO₂.

Description

A Gemella species was first described as Neisseria hemolysans in 1938. It was reclassified as a new genus in 1960 when strains were found to be distinct enough from Neisseria to require a new genus. The name was suggested based on the organism being a

diplococcus A diplococcus (plural diplococci) is a round bacterium (a coccus) that typically occurs in the form of two joined cells. Types Examples of gram-negative diplococci are '' Neisseria spp.'' and ''Moraxella catarrhalis.'' Examples of gram-positiv ...

and gemellus is the diminutive of geminus, which is Latin for twin. They are

facultatively anaerobic A facultative anaerobic organism is an organism that makes ATP by aerobic respiration if oxygen is present, but is capable of switching to fermentation if oxygen is absent. Some examples of facultatively anaerobic bacteria are ''Staphylococcus' ...

and give negative reactions to both

oxidase In biochemistry, an oxidase is an enzyme that catalyzes oxidation-reduction reactions, especially one involving dioxygen (O2) as the electron acceptor. In reactions involving donation of a hydrogen atom, oxygen is reduced to water (H2O) or hydro ...

and

catalase Catalase is a common enzyme found in nearly all living organisms exposed to oxygen (such as bacteria, plants, and animals) which catalyzes the decomposition of hydrogen peroxide to water and oxygen. It is a very important enzyme in protecting t ...

tests. They are obligately fermentative, producing either a mixture of acetic and lactic acids or an equimolar molar mixture of acetic acid and CO₂. For example, ''G. haemolysans'' ferments

glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, using ...

forming a mixture of acetic and lactic acids in the absence of

oxygen Oxygen is the chemical element with the symbol O and atomic number 8. It is a member of the chalcogen group in the periodic table, a highly reactive nonmetal, and an oxidizing agent that readily forms oxides with most elements as wel ...

, whereas when oxygen is present, it forms acetic acid and CO₂.

Clinical importance

''Gemella'' bacteria are primarily found in the

mucous membrane A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It is ...

s of humans and other animals, particularly in the

oral cavity In animal anatomy, the mouth, also known as the oral cavity, or in Latin cavum oris, is the opening through which many animals take in food and issue vocal sounds. It is also the cavity lying at the upper end of the alimentary canal, bounded on ...

and upper

digestive tract The gastrointestinal tract (GI tract, digestive tract, alimentary canal) is the tract or passageway of the digestive system that leads from the mouth to the anus. The GI tract contains all the major organs of the digestive system, in humans a ...

. ''Gemella haemolysans'' has been found to be involved in pulmonary exacerbations of

cystic fibrosis Cystic fibrosis (CF) is a rare genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. O ...

patients. As of the year 2000 it had been reported in 15 cases of human

endocarditis Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the ...

, mainly in men with underlying valvular disease and/or poor dentition or dental manipulation. Most cases were treated with a combination of penicillin and gentamicin with a favorable outcome. Additionally, ''Gemella asaccharolytica'' in bacterial vaginosis is associated with increase risk of HIV infection in unprotected sex.

References

Bacillales Bacteria genera {{Firmicutes-stub