General transcription factor IIH subunit 4 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''GTF2H4''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
Interactions
GTF2H4 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
GTF2F1
General transcription factor IIF subunit 1 is a protein that in humans is encoded by the ''GTF2F1'' gene.
Interactions
GTF2F1 has been shown to interact with:
* CTDP1,
* GTF2H4,
* HNRPU,
* MED21,
* POLR2A,
* Serum response factor
* T ...
,
[
* ]MED21
Mediator of RNA polymerase II transcription subunit 21 is an enzyme that in humans is encoded by the ''MED21'' gene.
Interactions
MED21 has been shown to interact with:
* BRCA1,
* CDK8,
* GTF2F1,
* GTF2H4,
* MED6, and
* POLR2A
DNA-directed ...
,POLR2A
DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the ''POLR2A'' gene.
Function
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing me ...
,[
* ]TATA binding protein
The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 30 base pairs upstream of the transcription start site in some eukaryotic gene p ...
,[
* ]Transcription Factor II B
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and pro ...
,[ and
* ]XPB
XPB (xeroderma pigmentosum type B) is an ATP-dependent DNA helicase in humans that is a part of the TFIIH transcription factor complex.
Structure
The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. Jo ...
.
See also
* Transcription Factor II H
Transcription factor II Human (transcription factor II H; TFIIH) is an important protein complex, having roles in transcription of various protein-coding genes and DNA nucleotide excision repair (NER) pathways. TFIIH first came to light in 1989 ...
References
Further reading
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External links
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Transcription factors
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