Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein (1009 aa) encoded by the ''GRID1'' gene. A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.

Function

This gene encodes a subunit of

glutamate receptor Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells. Glutamate (the conjugate base of glutamic acid) is abundant in the human body, but particularly in the nervous system ...

ligand-gated ion channel Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in res ...

. Most of these channels mediate fast excitatory synaptic transmission in the central nervous system. GluD1 is expressed in the central nervous system and is important in

synaptic plasticity In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuit ...

Clinical significance

Several genetic epidemiology studies have shown a strong association between several variants of the ''GRID1'' gene and increased risk of developing

schizophrenia Schizophrenia is a mental disorder characterized by continuous or relapsing episodes of psychosis. Major symptoms include hallucinations (typically hearing voices), delusions, and disorganized thinking. Other symptoms include social withdra ...

Function

Clinical significance

See also

References

Further reading