Francis Allan Plummer (2 December 1952 – 4 February 2020) was a Canadian scientist, academic and

HIV The human immunodeficiency viruses (HIV) are two species of ''Lentivirus'' (a subgroup of retrovirus) that infect humans. Over time, they cause acquired immunodeficiency syndrome (AIDS), a condition in which progressive failure of the immune ...

AIDS Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual m ...

researcher. He was "a recognized specialist in infectious diseases whose work influenced public health policy in Canada and abroad". He was Distinguished Professor Emeritus of Medicine and Medical Microbiology at the

University of Manitoba The University of Manitoba (U of M, UManitoba, or UM) is a Canadian public research university in the province of Manitoba.National Microbiology Laboratory The National Microbiology Laboratory (NML) is part of the Public Health Agency of Canada (PHAC), the agency of the Government of Canada that is responsible for public health, health emergency preparedness and response, and infectious and chronic d ...

Life and career

Plummer was born in

Winnipeg Winnipeg () is the capital and largest city of the province of Manitoba in Canada. It is centred on the confluence of the Red and Assiniboine rivers, near the longitudinal centre of North America. , Winnipeg had a city population of 749,6 ...

. He studied medicine at the University of Manitoba, where he specialized in infectious diseases. In 1980, he went to

Kenya ) , national_anthem = "Ee Mungu Nguvu Yetu"() , image_map = , map_caption = , image_map2 = , capital = Nairobi , coordinates = , largest_city = Nairobi , ...

in response to a request from the

University of Nairobi , mottoeng = In unity and work , image = Uon emblem.gif , image_size = 210px , caption = Coat of Arms of the University , type = Public , endowment ...

for assistance in managing an outbreak of

chancroid Chancroid ( ) is a bacterial sexually transmitted infection characterized by painful sores on the genitalia. Chancroid is known to spread from one individual to another solely through sexual contact. However, there have been reports of accidenta ...

. While there, in 1982 he began studying AIDS transmission in 1982, and beginning in 1984 was part of a research collaboration in

Nairobi Nairobi ( ) is the capital and largest city of Kenya. The name is derived from the Maasai phrase ''Enkare Nairobi'', which translates to "place of cool waters", a reference to the Nairobi River which flows through the city. The city proper ha ...

between the University of Manitoba and the University of Nairobi studying sexually transmitted infections. His research described the heterosexual epidemiology of HIV, the increased risk of HIV infection in men associated with previous chancroid infection and of male circumcision in reducing such risk, and identified immunological and genetic features shared by a group of female sex workers who demonstrated immunity to HIV. On returning to Canada in 1999, he became senior scientific advisor to the

Public Health Agency of Canada The Public Health Agency of Canada (PHAC; french: Agence de la santé publique du Canada, ASPC) is an agency of the Government of Canada that is responsible for public health, emergency preparedness and response, and infectious and chronic diseas ...

, director general of the Centre for Infectious Disease Prevention and Control, and scientific director general of the National Microbiology Laboratory, where he remained for 13 years, leading the Canadian laboratory response to

SARS Severe acute respiratory syndrome (SARS) is a viral respiratory disease of zoonotic origin caused by the severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1), the first identified strain of the SARS coronavirus species, ''sever ...

and the

H1N1 pandemic The 2009 swine flu pandemic, caused by the H1N1 influenza virus and declared by the World Health Organization (WHO) from June 2009 to August 2010, is the third recent flu pandemic involving the H1N1 virus (the first being the 1918–1920 Span ...

and overseeing the development of the successful VSV EBOV vaccine for Ebola viral hemorrhagic fever. Among his other research, Plummer discovered a human

parvovirus Parvoviruses are a family of animal viruses that constitute the family ''Parvoviridae''. They have linear, single-stranded DNA (ssDNA) genomes that typically contain two genes encoding for a replication initiator protein, called NS1, and the pr ...

that causes a disease resembling

erythema infectiosum Erythema infectiosum, fifth disease, or slapped cheek syndrome is one of several possible manifestations of infection by parvovirus B19. Fifth disease typically presents as a rash and is more common in children. While parvovirus B19 can affect h ...

, which has played an important role in development of

adeno-associated virus Adeno-associated viruses (AAV) are small viruses that infect humans and some other primate species. They belong to the genus ''Dependoparvovirus'', which in turn belongs to the family ''Parvoviridae''. They are small (approximately 26 nm in di ...

gene therapy Gene therapy is a medical field which focuses on the genetic modification of cells to produce a therapeutic effect or the treatment of disease by repairing or reconstructing defective genetic material. The first attempt at modifying human DN ...

. At the time of his death, he was working to develop an HIV vaccine.

Honours

In 2006, Plummer was made an Officer of the

Order of Canada The Order of Canada (french: Ordre du Canada; abbreviated as OC) is a Canadian state order and the second-highest honour for merit in the system of orders, decorations, and medals of Canada, after the Order of Merit. To coincide with the ...

. In 2009, he was made a Member of the

Order of Manitoba The Order of Manitoba (french: Ordre du Manitoba) is a civilian honour for merit in the Canadian province of Manitoba. Instituted in 1999 when Lieutenant Governor Peter Liba granted Royal Assent to The Order of Manitoba Act, the order is administe ...

in recognition for being "an internationally renowned physician-scientist and expert in infectious diseases who has significantly contributed to global health". In 2014, he was awarded the

Killam Prize The Izaak Walton Killam Memorial Prize was established according to the will of Dorothy J. Killam to honour the memory of her husband Izaak Walton Killam. Five Killam Prizes, each having a value of $100,000, are annually awarded by the Canada Cou ...

for AIDS research. In 2012, he was awarded the

Royal Society of Canada The Royal Society of Canada (RSC; french: Société royale du Canada, SRC), also known as the Academies of Arts, Humanities and Sciences of Canada (French: ''Académies des arts, des lettres et des sciences du Canada''), is the senior national, bil ...

's McLaughlin Medal, awarded "for important research of sustained excellence in medical science". He was the recipient of the Canada Gairdner Wightman Award in 2016. Plummer had honorary degrees from the

University of Calgary The University of Calgary (U of C or UCalgary) is a public research university located in Calgary, Alberta, Canada. The University of Calgary started in 1944 as the Calgary branch of the University of Alberta, founded in 1908, prior to being ins ...

McMaster University McMaster University (McMaster or Mac) is a public research university in Hamilton, Ontario, Canada. The main McMaster campus is on of land near the residential neighbourhoods of Ainslie Wood and Westdale, adjacent to the Royal Botanical Ga ...

, and the

University of Windsor , mottoeng = Goodness, Discipline and Knowledge , established = , academic_affiliations = CARL, COU, Universities Canada , former_names = Assumption College (1857-1956)Assumption University of Windsor (1956-1963) , type = Public universit ...

Private life and death

Plummer was married to Dr. Jo Kennelly; he had three stepchildren and three daughters, and lived in

Toronto Toronto ( ; or ) is the capital city of the Canadian province of Ontario. With a recorded population of 2,794,356 in 2021, it is the most populous city in Canada and the fourth most populous city in North America. The city is the ancho ...

. In 2012, Plummer developed liver failure due to alcoholism; he underwent a liver transplant and as part of an experimental trial was the first recipient in North America of

deep brain stimulation Deep brain stimulation (DBS) is a neurosurgical procedure involving the placement of a medical device called a neurostimulator, which sends electrical impulses, through implanted electrodes, to specific targets in the brain (the brain nucleu ...

for alcohol-use disorder, in December 2018. He died of a heart attack on 4 February 2020, while visiting Nairobi for the 40th anniversary of the HIV research collaboration.

References

{{DEFAULTSORT:Plummer, Frank 1952 births 2020 deaths Fellows of the Royal Society of Canada HIV/AIDS researchers Members of the Order of Manitoba Officers of the Order of Canada University of Manitoba faculty Canadian microbiologists 20th-century Canadian biologists 21st-century Canadian biologists