Folin's reagent or sodium 1,2-naphthoquinone-4-sulfonate is a chemical reagent used as a
derivatizing agent to measure levels of
amines and
amino acids. The reagent reacts with them in
alkaline
In chemistry, an alkali (; from ar, القلوي, al-qaly, lit=ashes of the saltwort) is a base (chemistry), basic, ionic compound, ionic salt (chemistry), salt of an alkali metal or an alkaline earth metal. An alkali can also be defined as ...
solution to produce a
fluorescent material that can be easily detected.

This should not be confused with
Folin-Ciocalteu reagent, that is used to detect
phenolic compounds.
The Folin reagent can be used with an acidic secondary reagent to distinguish
MDMA and related compounds from
PMMA and related compounds.
See also
*
Pill testing
*
Sullivan reaction
Sullivan may refer to:
People
Characters
* Chloe Sullivan, from the television series ''Smallville''
* Colin Sullivan, a character in the film ''The Departed'', played by Matt Damon
* Harry Sullivan (''Doctor Who''), from the British science f ...
*
Dille–Koppanyi reagent
*
Froehde reagent
*
Liebermann reagent
*
Mandelin reagent
*
Marquis reagent
*
Mecke reagent
The Mecke reagent is used as a simple spot-test to presumptively identify alkaloids as well as other compounds. It is composed of a mixture of selenous acid and concentrated sulfuric acid, which is dripped onto the substance being tested.
The Unit ...
*
Simon's reagent
*
Zwikker reagent
References
{{reflist
Biochemistry detection reactions
Chemical tests
Drug testing reagents
1,2-Naphthoquinones
Naphthalenesulfonates