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Enrico Fermi (; 29 September 1901 – 28 November 1954) was an Italian (later naturalized American) physicist and the creator of the world's first nuclear reactor, the Chicago Pile-1. He has been called the "architect of the nuclear age" and the "architect of the atomic bomb". He was one of very few physicists to excel in both theoretical physics and experimental physics. Fermi was awarded the 1938 Nobel Prize in Physics for his work on induced radioactivity by neutron bombardment and for the discovery of transuranium elements. With his colleagues, Fermi filed several patents related to the use of nuclear power, all of which were taken over by the US government. He made significant contributions to the development of statistical mechanics, quantum theory, and nuclear and particle physics.

Fermi's first major contribution involved the field of statistical mechanics. After Wolfgang Pauli formulated his exclusion principle in 1925, Fermi followed with a paper in which he applied the principle to an ideal gas, employing a statistical formulation now known as Fermi–Dirac statistics. Today, particles that obey the exclusion principle are called "fermions". Pauli later postulated the existence of an uncharged invisible particle emitted along with an electron during beta decay, to satisfy the law of conservation of energy. Fermi took up this idea, developing a model that incorporated the postulated particle, which he named the "neutrino". His theory, later referred to as Fermi's interaction and now called weak interaction, described one of the four fundamental interactions in nature. Through experiments inducing radioactivity with the recently discovered neutron, Fermi discovered that slow neutrons were more easily captured by atomic nuclei than fast ones, and he developed the Fermi age equation to describe this. After bombarding thorium and uranium with slow neutrons, he concluded that he had created new elements. Although he was awarded the Nobel Prize for this discovery, the new elements were later revealed to be nuclear fission products.

Fermi left Italy in 1938 to escape new Italian racial laws that affected his Jewish wife, Laura Capon. He emigrated to the United States, where he worked on the Manhattan Project during World War II. Fermi led the team at the University of Chicago that designed and built Chicago Pile-1, which went critical on 2 December 1942, demonstrating the first human-created, self-sustaining nuclear chain reaction. He was on hand when the X-10 Graphite Reactor at Oak Ridge, Tennessee, went critical in 1943, and when the B Reactor at the Hanford Site did so the next year. At Los Alamos, he headed F Division, part of which worked on Edward Teller's thermonuclear "Super" bomb. He was present at the Trinity test on 16 July 1945, where he used his Fermi method to estimate the bomb's yield.

After the war, Fermi served under J. Robert Oppenheimer on the General Advisory Committee, which advised the Atomic Energy Commission on nuclear matters. After the detonation of the first Soviet fission bomb in August 1949, he strongly opposed the development of a hydrogen bomb on both moral and technical grounds. He was among the scientists who testified on Oppenheimer's behalf at the 1954 hearing that resulted in the denial of Oppenheimer's security clearance. Fermi did important work in particle physics, especially related to pions and muons, and he speculated that cosmic rays arose when material was accelerated by magnetic fields in interstellar space. Many awards, concepts, and institutions are named after Fermi, including the Enrico Fermi Award, the Enrico Fermi Institute, the Fermi National Accelerator Laboratory (Fermilab), the Fermi Gamma-ray Space Telescope, and the synthetic element fermium, making him one of 16 scientists who have elements named after them. Fermi tutored or directly influenced no fewer than eight young researchers who went on to win Nobel Prizes.

Early life

Enrico Fermi was born in Rome, Italy, on 29 September 1901. He was the third child of Alberto Fermi, a division head in the Ministry of Railways, and Ida de Gattis, an elementary school teacher. His sister, Maria, was two years older, his brother Giulio a year older. After the two boys were sent to a rural community to be wet nursed, Enrico rejoined his family in Rome when he was two and a half. Although he was baptized a Roman Catholic in accordance with his grandparents' wishes, his family was not particularly religious; Enrico was an agnostic throughout his adult life. As a young boy, he shared the same interests as his brother Giulio, building electric motors and playing with electrical and mechanical toys. Giulio died during an operation on a throat abscess in 1915 and Maria died in an airplane crash near Milan in 1959.

At a local market in Campo de' Fiori Fermi found a physics book, the 900-page ''Elementorum physicae mathematicae''. Written in Latin by Jesuit Father , a professor at the Collegio Romano, it presented mathematics, classical mechanics, astronomy, optics, and acoustics as they were understood at the time of its 1840 publication. With a scientifically inclined friend, Enrico Persico, Fermi pursued projects such as building gyroscopes and measuring the acceleration of Earth's gravity.

In 1914, Fermi, who used to often meet with his father in front of the office after work, met a colleague of his father called Adolfo Amidei, who would walk part of the way home with Alberto. Enrico had learned that Adolfo was interested in mathematics and physics and took the opportunity to ask Adolfo a question about geometry. Adolfo understood that the young Fermi was referring to projective geometry and then proceeded to give him a book on the subject written by Theodor Reye. Two months later, Fermi returned the book, having solved all the problems proposed at the end of the book, some of which Adolfo considered difficult. Upon verifying this, Adolfo felt that Fermi was "a prodigy, at least with respect to geometry", and further mentored the boy, providing him with more books on physics and mathematics. Adolfo noted that Fermi had a very good memory and thus could return the books after having read them because he could remember their content very well.

''Scuola Normale Superiore'' in Pisa

Fermi graduated from high school in July 1918, having skipped the third year entirely. At Amidei's urging, Fermi learned German to be able to read the many scientific papers that were published in that language at the time, and he applied to the ''Scuola Normale Superiore'' in Pisa. Amidei felt that the Scuola would provide better conditions for Fermi's development than the Sapienza University of Rome could at the time. Having lost one son, Fermi's parents only reluctantly allowed him to live in the school's lodgings away from Rome for four years. Fermi took first place in the difficult entrance exam, which included an essay on the theme of "Specific characteristics of Sounds"; the 17-year-old Fermi chose to use Fourier analysis to derive and solve the partial differential equation for a vibrating rod, and after interviewing Fermi the examiner declared he would become an outstanding physicist.

At the ''Scuola Normale Superiore'', Fermi played pranks with fellow student Franco Rasetti; the two became close friends and collaborators. Fermi was advised by Luigi Puccianti, director of the physics laboratory, who said there was little he could teach Fermi and often asked Fermi to teach him something instead. Fermi's knowledge of quantum physics was such that Puccianti asked him to organize seminars on the topic. During this time Fermi learned tensor calculus, a technique key to general relativity. Fermi initially chose mathematics as his major, but soon switched to physics. He remained largely self-taught, studying general relativity, quantum mechanics, and atomic physics.

In September 1920, Fermi was admitted to the Physics department. Since there were only three students in the department—Fermi, Rasetti, and Nello Carrara—Puccianti let them freely use the laboratory for whatever purposes they chose. Fermi decided that they should research X-ray crystallography, and the three worked to produce a Laue photograph—an X-ray photograph of a crystal. During 1921, his third year at the university, Fermi published his first scientific works in the Italian journal ''Nuovo Cimento''. The first was entitled "On the dynamics of a rigid system of electrical charges in translational motion" ('). A sign of things to come was that the mass was expressed as a tensor—a mathematical construct commonly used to describe something moving and changing in three-dimensional space. In classical mechanics, mass is a scalar quantity, but in relativity, it changes with velocity. The second paper was "On the electrostatics of a uniform gravitational field of electromagnetic charges and on the weight of electromagnetic charges" ('). Using general relativity, Fermi showed that a charge has a weight equal to U/c², where U was the electrostatic energy of the system, and c is the speed of light.

The first paper seemed to point out a contradiction between the electrodynamic theory and the relativistic one concerning the calculation of the electromagnetic masses, as the former predicted a value of 4/3 U/c². Fermi addressed this the next year in a paper "Concerning a contradiction between electrodynamic and the relativistic theory of electromagnetic mass" in which he showed that the apparent contradiction was a consequence of relativity. This paper was sufficiently well-regarded that it was translated into German and published in the German scientific journal '' Physikalische Zeitschrift'' in 1922. That year, Fermi submitted his article "On the phenomena occurring near a world line" (') to the Italian journal '. In this article he examined the Principle of Equivalence, and introduced the so-called "Fermi coordinates". He proved that on a world line close to the timeline, space behaves as if it were a Euclidean space.

Fermi submitted his thesis, "A theorem on probability and some of its applications" ('), to the ''Scuola Normale Superiore'' in July 1922, and received his laurea at the unusually young age of 20. The thesis was on X-ray diffraction images. Theoretical physics was not yet considered a discipline in Italy, and the only thesis that would have been accepted was experimental physics. For this reason, Italian physicists were slow in embracing the new ideas like relativity coming from Germany. Since Fermi was quite at home in the lab doing experimental work, this did not pose insurmountable problems for him.

While writing the appendix for the Italian edition of the book ''Fundamentals of Einstein Relativity'' by August Kopff in 1923, Fermi was the first to point out that hidden inside the Einstein equation () was an enormous amount of nuclear potential energy to be exploited. "It does not seem possible, at least in the near future", he wrote, "to find a way to release these dreadful amounts of energy—which is all to the good because the first effect of an explosion of such a dreadful amount of energy would be to smash into smithereens the physicist who had the misfortune to find a way to do it."

In 1924, Fermi was initiated into the Masonic Lodge "Adriano Lemmi" of the Grand Orient of Italy.

In 1923–1924, Fermi spent a semester studying under Max Born at the University of Göttingen, where he met Werner Heisenberg and Pascual Jordan. Fermi then studied in Leiden with Paul Ehrenfest from September to December 1924 on a fellowship from the Rockefeller Foundation obtained through the intercession of the mathematician Vito Volterra. Here Fermi met Hendrik Lorentz and Albert Einstein, and became friends with Samuel Goudsmit and Jan Tinbergen. From January 1925 to late 1926, Fermi taught mathematical physics and theoretical mechanics at the University of Florence, where he teamed up with Rasetti to conduct a series of experiments on the effects of magnetic fields on mercury vapor. He also participated in seminars at the Sapienza University of Rome, giving lectures on quantum mechanics and solid state physics. While giving lectures on the new quantum mechanics based on the remarkable accuracy of predictions of the Schrödinger equation, Fermi would often say, "It has no business to fit so well!"

After Wolfgang Pauli announced his exclusion principle in 1925, Fermi responded with a paper "On the quantization of the perfect monoatomic gas" ('), in which he applied the exclusion principle to an ideal gas. The paper was especially notable for Fermi's statistical formulation, which describes the distribution of particles in systems of many identical particles that obey the exclusion principle. This was independently developed soon after by the British physicist Paul Dirac, who also showed how it was related to the Bose–Einstein statistics. Accordingly, it is now known as Fermi–Dirac statistics. After Dirac, particles that obey the exclusion principle are today called "fermions", while those that do not are called " bosons".

Professor in Rome

Professorships in Italy were granted by competition (') for a vacant chair, the applicants being rated on their publications by a committee of professors. Fermi applied for a chair of mathematical physics at the University of Cagliari on Sardinia, but was narrowly passed over in favor of Giovanni Giorgi. In 1926, at the age of 24, he applied for a professorship at the Sapienza University of Rome. This was a new chair, one of the first three in theoretical physics in Italy, that had been created by the Minister of Education at the urging of Professor Orso Mario Corbino, who was the university's professor of experimental physics, the Director of the Institute of Physics, and a member of Benito Mussolini's cabinet. Corbino, who also chaired the selection committee, hoped that the new chair would raise the standard and reputation of physics in Italy. The committee chose Fermi ahead of Enrico Persico and Aldo Pontremoli, and Corbino helped Fermi recruit his team, which was soon joined by notable students such as Edoardo Amaldi, Bruno Pontecorvo, Ettore Majorana and Emilio Segrè, and by Franco Rasetti, whom Fermi had appointed as his assistant. They soon nicknamed the " Via Panisperna boys" after the street where the Institute of Physics was located.

Fermi married Laura Capon, a science student at the university, on 19 July 1928. They had two children: Nella, born in January 1931, and Giulio, born in February 1936. On 18 March 1929, Fermi was appointed a member of the Royal Academy of Italy by Mussolini, and on 27 April he joined the Fascist Party. He later opposed Fascism when the 1938 racial laws were promulgated by Mussolini in order to bring Italian Fascism ideologically closer to German Nazism. These laws threatened Laura, who was Jewish, and put many of Fermi's research assistants out of work.

During their time in Rome, Fermi and his group made important contributions to many practical and theoretical aspects of physics. In 1928, he published his ''Introduction to Atomic Physics'' ('), which provided Italian university students with an up-to-date and accessible text. Fermi also conducted public lectures and wrote popular articles for scientists and teachers in order to spread knowledge of the new physics as widely as possible. Part of his teaching method was to gather his colleagues and graduate students together at the end of the day and go over a problem, often from his own research. A sign of success was that foreign students now began to come to Italy. The most notable of these was the German physicist Hans Bethe, who came to Rome as a Rockefeller Foundation fellow, and collaborated with Fermi on a 1932 paper "On the Interaction between Two Electrons" ().

At this time, physicists were puzzled by beta decay, in which an electron was emitted from the atomic nucleus. To satisfy the law of conservation of energy, Pauli postulated the existence of an invisible particle with no charge and little or no mass that was also emitted at the same time. Fermi took up this idea, which he developed in a tentative paper in 1933, and then a longer paper the next year that incorporated the postulated particle, which Fermi called a "neutrino". His theory, later referred to as Fermi's interaction, and still later as the theory of the weak interaction, described one of the four fundamental forces of nature. The neutrino was detected after his death, and his interaction theory showed why it was so difficult to detect. When he submitted his paper to the British journal '' Nature'', that journal's editor turned it down because it contained speculations which were "too remote from physical reality to be of interest to readers". Thus Fermi saw the theory published in Italian and German before it was published in English.

In the introduction to the 1968 English translation, physicist Fred L. Wilson noted that:

In January 1934, Irène Joliot-Curie and Frédéric Joliot announced that they had bombarded elements with alpha particles and induced radioactivity in them. By March, Fermi's assistant Gian-Carlo Wick had provided a theoretical explanation using Fermi's theory of beta decay. Fermi decided to switch to experimental physics, using the neutron, which James Chadwick had discovered in 1932. In March 1934, Fermi wanted to see if he could induce radioactivity with Rasetti's polonium- beryllium neutron source. Neutrons had no electric charge, and so would not be deflected by the positively charged nucleus. This meant that they needed much less energy to penetrate the nucleus than charged particles, and so would not require a particle accelerator, which the Via Panisperna boys did not have.

Fermi had the idea to resort to replacing the polonium-beryllium neutron source with a radon-beryllium one, which he created by filling a glass bulb with beryllium powder, evacuating the air, and then adding 50 m Ci of radon gas, supplied by Giulio Cesare Trabacchi. This created a much stronger neutron source, the effectiveness of which declined with the 3.8-day half-life of radon. He knew that this source would also emit gamma rays, but, on the basis of his theory, he believed that this would not affect the results of the experiment. He started by bombarding platinum, an element with a high atomic number that was readily available, without success. He turned to aluminium, which emitted an alpha particle and produced sodium, which then decayed into magnesium by beta particle emission. He tried lead, without success, and then fluorine in the form of calcium fluoride, which emitted an alpha particle and produced nitrogen, decaying into oxygen by beta particle emission. In all, he induced radioactivity in 22 different elements. Fermi rapidly reported the discovery of neutron-induced radioactivity in the Italian journal ''La Ricerca Scientifica'' on 25 March 1934.

The natural radioactivity of thorium and uranium made it hard to determine what was happening when these elements were bombarded with neutrons but, after correctly eliminating the presence of elements lighter than uranium but heavier than lead, Fermi concluded that they had created new elements, which he called hesperium and ausonium. The chemist Ida Noddack suggested that some of the experiments could have produced lighter elements than lead rather than new, heavier elements. Her suggestion was not taken seriously at the time because her team had not carried out any experiments with uranium or built the theoretical basis for this possibility. At that time, fission was thought to be improbable if not impossible on theoretical grounds. While physicists expected elements with higher atomic numbers to form from neutron bombardment of lighter elements, nobody expected neutrons to have enough energy to split a heavier atom into two light element fragments in the manner that Noddack suggested.

The Via Panisperna boys also noticed some unexplained effects. The experiment seemed to work better on a wooden table than a marble tabletop. Fermi remembered that Joliot-Curie and Chadwick had noted that paraffin wax was effective at slowing neutrons, so he decided to try that. When neutrons were passed through paraffin wax, they induced a hundred times as much radioactivity in silver compared with when it was bombarded without the paraffin. Fermi guessed that this was due to the hydrogen atoms in the paraffin. Those in wood similarly explained the difference between the wooden and the marble tabletops. This was confirmed by repeating the effect with water. He concluded that collisions with hydrogen atoms slowed the neutrons. The lower the atomic number of the nucleus it collides with, the more energy a neutron loses per collision, and therefore the fewer collisions that are required to slow a neutron down by a given amount. Fermi realised that this induced more radioactivity because slow neutrons were more easily captured than fast ones. He developed a diffusion equation to describe this, which became known as the Fermi age equation.

In 1938, Fermi received the Nobel Prize in Physics at the age of 37 for his "demonstrations of the existence of new radioactive elements produced by neutron irradiation, and for his related discovery of nuclear reactions brought about by slow neutrons". After Fermi received the prize in Stockholm, he did not return home to Italy but rather continued to New York City with his family in December 1938, where they applied for permanent residency. The decision to move to America and become US citizens was due primarily to the racial laws in Italy.

Manhattan Project

Fermi arrived in New York City on 2 January 1939. He was immediately offered positions at five universities, and accepted one at Columbia University, where he had already given summer lectures in 1936. He received the news that in December 1938, the German chemists Otto Hahn and Fritz Strassmann had detected the element barium after bombarding uranium with neutrons, which Lise Meitner and her nephew Otto Frisch correctly interpreted as the result of nuclear fission. Frisch confirmed this experimentally on 13 January 1939. The news of Meitner and Frisch's interpretation of Hahn and Strassmann's discovery crossed the Atlantic with Niels Bohr, who was to lecture at Princeton University. Isidor Isaac Rabi and Willis Lamb, two Columbia University physicists working at Princeton, found out about it and carried it back to Columbia. Rabi said he told Enrico Fermi, but Fermi later gave the credit to Lamb:

Noddack was proven right after all. Fermi had dismissed the possibility of fission on the basis of his calculations, but he had not taken into account the binding energy that would appear when a nuclide with an odd number of neutrons absorbed an extra neutron. For Fermi, the news came as a profound embarrassment, as the transuranic elements that he had partly been awarded the Nobel Prize for discovering had not been transuranic elements at all, but fission products. He added a footnote to this effect to his Nobel Prize acceptance speech.

The scientists at Columbia decided that they should try to detect the energy released in the nuclear fission of uranium when bombarded by neutrons. On 25 January 1939, in the basement of Pupin Hall at Columbia, an experimental team including Fermi conducted the first nuclear fission experiment in the United States. The other members of the team were Herbert L. Anderson, Eugene T. Booth, John R. Dunning, G. Norris Glasoe, and Francis G. Slack. The next day, the Fifth Washington Conference on Theoretical Physics began in Washington, D.C. under the joint auspices of George Washington University and the Carnegie Institution of Washington. There, the news on nuclear fission was spread even further, fostering many more experimental demonstrations.

French scientists Hans von Halban, Lew Kowarski, and Frédéric Joliot-Curie had demonstrated that uranium bombarded by neutrons emitted more neutrons than it absorbed, suggesting the possibility of a chain reaction. Fermi and Anderson did so too a few weeks later. Leó Szilárd obtained of uranium oxide from Canadian radium producer Eldorado Gold Mines Limited, allowing Fermi and Anderson to conduct experiments with fission on a much larger scale. Fermi and Szilárd collaborated on a design of a device to achieve a self-sustaining nuclear reaction—a nuclear reactor. Owing to the rate of absorption of neutrons by the hydrogen in water, it was unlikely that a self-sustaining reaction could be achieved with natural uranium and water as a neutron moderator. Fermi suggested, based on his work with neutrons, that the reaction could be achieved with uranium oxide blocks and graphite as a moderator instead of water. This would reduce the neutron capture rate, and in theory make a self-sustaining chain reaction possible. Szilárd came up with a workable design: a pile of uranium oxide blocks interspersed with graphite bricks. Szilárd, Anderson, and Fermi published a paper on "Neutron Production in Uranium". But their work habits and personalities were different, and Fermi had trouble working with Szilárd.

Fermi was among the first to warn military leaders about the potential impact of nuclear energy, giving a lecture on the subject at the Navy Department on 18 March 1939. The response fell short of what he had hoped for, although the Navy agreed to provide $1,500 towards further research at Columbia. Later that year, Szilárd, Eugene Wigner, and Edward Teller sent the letter signed by Einstein to US president Franklin D. Roosevelt, warning that Nazi Germany was likely to build an atomic bomb. In response, Roosevelt formed the Advisory Committee on Uranium to investigate the matter.

The Advisory Committee on Uranium provided money for Fermi to buy graphite, and he built a pile of graphite bricks on the seventh floor of the Pupin Hall laboratory. By August 1941, he had six tons of uranium oxide and thirty tons of graphite, which he used to build a still larger pile in Schermerhorn Hall at Columbia.

The S-1 Section of the Office of Scientific Research and Development, as the Advisory Committee on Uranium was now known, met on 18 December 1941, with the US now engaged in World War II, making its work urgent. Most of the effort sponsored by the committee had been directed at producing enriched uranium, but Committee member Arthur Compton determined that a feasible alternative was plutonium, which could be mass-produced in nuclear reactors by the end of 1944. He decided to concentrate the plutonium work at the University of Chicago. Fermi reluctantly moved, and his team became part of the new Metallurgical Laboratory there.

The possible results of a self-sustaining nuclear reaction were unknown, so it seemed inadvisable to build the first nuclear reactor on the University of Chicago campus in the middle of the city. Compton found a location in the Argonne Woods Forest Preserve, about from Chicago. Stone & Webster was contracted to develop the site, but the work was halted by an industrial dispute. Fermi then persuaded Compton that he could build the reactor in the squash court under the stands of the University of Chicago's Stagg Field. Construction of the pile began on 6 November 1942, and Chicago Pile-1 went critical on 2 December. The shape of the pile was intended to be roughly spherical, but as work proceeded Fermi calculated that criticality could be achieved without finishing the entire pile as planned.

This experiment was a landmark in the quest for energy, and it was typical of Fermi's approach. Every step was carefully planned, every calculation was meticulously done. When the first self-sustained nuclear chain reaction was achieved, Compton made a coded phone call to James B. Conant, the chairman of the National Defense Research Committee.

To continue the research where it would not pose a public health hazard, the reactor was disassembled and moved to the Argonne Woods site. There Fermi directed experiments on nuclear reactions, reveling in the opportunities provided by the reactor's abundant production of free neutrons. The laboratory soon branched out from physics and engineering into using the reactor for biological and medical research. Initially, Argonne was run by Fermi as part of the University of Chicago, but it became a separate entity with Fermi as its director in May 1944.

When the air-cooled X-10 Graphite Reactor at Oak Ridge went critical on 4 November 1943, Fermi was on hand just in case something went wrong. The technicians woke him early so that he could see it happen. Getting X-10 operational was another milestone in the plutonium project. It provided data on reactor design, training for DuPont staff in reactor operation, and produced the first small quantities of reactor-bred plutonium. Fermi became an American citizen in July 1944, the earliest date the law allowed.

In September 1944, Fermi inserted the first uranium fuel slug into the B Reactor at the Hanford Site, the production reactor designed to breed plutonium in large quantities. Like X-10, it had been designed by Fermi's team at the Metallurgical Laboratory and built by DuPont, but it was much larger and was water-cooled. Over the next few days, 838 tubes were loaded, and the reactor went critical. Shortly after midnight on 27 September, the operators began to withdraw the control rods to initiate production. At first, all appeared to be well, but around 03:00, the power level started to drop and by 06:30 the reactor had shut down completely. The Army and DuPont turned to Fermi's team for answers. The cooling water was investigated to see if there was a leak or contamination. The next day the reactor suddenly started up again, only to shut down once more a few hours later. The problem was traced to neutron poisoning from xenon-135 or Xe-135, a fission product with a half-life of 9.1 to 9.4 hours. Fermi and John Wheeler both deduced that Xe-135 was responsible for absorbing neutrons in the reactor, thereby sabotaging the fission process. Fermi was recommended by colleague Emilio Segrè to ask Chien-Shiung Wu, as she prepared a printed draft on this topic to be published by the Physical Review. Upon reading the draft, Fermi and the scientists confirmed their suspicions: Xe-135 indeed absorbed neutrons, in fact it had a huge neutron cross-section. DuPont had deviated from the Metallurgical Laboratory's original design in which the reactor had 1,500 tubes arranged in a circle, and had added 504 tubes to fill in the corners. The scientists had originally considered this over-engineering a waste of time and money, but Fermi realized that if all 2,004 tubes were loaded, the reactor could reach the required power level and efficiently produce plutonium.

In April 1943, Fermi raised with Robert Oppenheimer the possibility of using the radioactive byproducts from enrichment to contaminate the German food supply. The background was fear that the German atomic bomb project was already at an advanced stage, and Fermi was also skeptical at the time that an atomic bomb could be developed quickly enough. Oppenheimer discussed the "promising" proposal with Edward Teller, who suggested the use of strontium-90. James B. Conant and Leslie Groves were also briefed, but Oppenheimer wanted to proceed with the plan only if enough food could be contaminated with the weapon to kill half a million people.

In mid-1944, Oppenheimer persuaded Fermi to join his Project Y at Los Alamos, New Mexico. Arriving in September, Fermi was appointed an associate director of the laboratory, with broad responsibility for nuclear and theoretical physics, and was placed in charge of F Division, which was named after him. F Division had four branches: F-1 Super and General Theory under Teller, which investigated the "Super" (thermonuclear) bomb; F-2 Water Boiler under L. D. P. King, which looked after the "water boiler" aqueous homogeneous research reactor; F-3 Super Experimentation under Egon Bretscher; and F-4 Fission Studies under Anderson. Fermi observed the Trinity test on 16 July 1945 and conducted an experiment to estimate the bomb's yield by dropping strips of paper into the blast wave. He paced off the distance they were blown by the explosion, and calculated the yield as ten kilotons of TNT; the actual yield was about 18.6 kilotons.

Along with Oppenheimer, Compton, and Ernest Lawrence, Fermi was part of the scientific panel that advised the Interim Committee on target selection. The panel agreed with the committee that atomic bombs would be used without warning against an industrial target. Like others at the Los Alamos Laboratory, Fermi found out about the atomic bombings of Hiroshima and Nagasaki from the public address system in the technical area. Fermi did not believe that atomic bombs would deter nations from starting wars, nor did he think that the time was ripe for world government. He therefore did not join the Association of Los Alamos Scientists.

Postwar work

Fermi became the Charles H. Swift Distinguished Professor of Physics at the University of Chicago on 1 July 1945, although he did not depart the Los Alamos Laboratory with his family until 31 December 1945. He was elected a member of the US National Academy of Sciences in 1945. The Metallurgical Laboratory became the Argonne National Laboratory on 1 July 1946, the first of the national laboratories established by the Manhattan Project. The short distance between Chicago and Argonne allowed Fermi to work at both places. At Argonne he continued experimental physics, investigating neutron scattering with Leona Marshall. He also discussed theoretical physics with Maria Mayer, helping her develop insights into spin–orbit coupling that would lead to her receiving the Nobel Prize.

The Manhattan Project was replaced by the Atomic Energy Commission (AEC) on 1 January 1947. Fermi served on the AEC General Advisory Committee, an influential scientific committee chaired by Robert Oppenheimer. He also liked to spend a few weeks of each year at the Los Alamos National Laboratory, where he collaborated with Nicholas Metropolis, and with John von Neumann on Rayleigh–Taylor instability, the science of what occurs at the border between two fluids of different densities.

After the detonation of the first Soviet fission bomb in August 1949, Fermi, along with Isidor Rabi, wrote a strongly worded report for the committee, opposing the development of a hydrogen bomb on moral and technical grounds. Nonetheless, Fermi continued to participate in work on the hydrogen bomb at Los Alamos as a consultant. Along with Stanislaw Ulam, he calculated that not only would the amount of tritium needed for Teller's model of a thermonuclear weapon be prohibitive, but a fusion reaction could still not be assured to propagate even with this large quantity of tritium. Fermi was among the scientists who testified on Oppenheimer's behalf at the Oppenheimer security hearing in 1954 that resulted in denial of Oppenheimer's security clearance.

In his later years, Fermi continued teaching at the University of Chicago, where he was a founder of what later became the Enrico Fermi Institute. His PhD students in the postwar period included Owen Chamberlain, Geoffrey Chew, Jerome Friedman, Marvin Goldberger, Tsung-Dao Lee, Arthur Rosenfeld and Sam Treiman. including the Nobel Lecture, 12 December 1938 ''Artificial Radioactivity Produced by Neutron Bombardment'' Jack Steinberger was a graduate student, and Mildred Dresselhaus was highly influenced by Fermi during the year she overlapped with him as a PhD student. Fermi conducted important research in particle physics, especially related to pions and muons. He made the first predictions of pion- nucleon resonance, relying on statistical methods, since he reasoned that exact answers were not required when the theory was wrong anyway. In a paper coauthored with Chen Ning Yang, he speculated that pions might actually be composite particles. The idea was elaborated by Shoichi Sakata. It has since been supplanted by the quark model, in which the pion is made up of quarks, which completed Fermi's model, and vindicated his approach.

Fermi wrote a paper "On the Origin of Cosmic Radiation" in which he proposed that cosmic rays arose through material being accelerated by magnetic fields in interstellar space, which led to a difference of opinion with Teller. Fermi examined the issues surrounding magnetic fields in the arms of a spiral galaxy

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