Fan Wang is a neuroscientist and professor in the

MIT Department of Brain and Cognitive Sciences The Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology, Cambridge, Massachusetts, United States, engages in fundamental research in the areas of brain and neural systems, and cognitive processes. The department ...

. She is an investigator at the

McGovern Institute for Brain Research The McGovern Institute for Brain Research is a research institute within MIT. Its mission is to understand how the brain works and to discover new ways to prevent or treat brain disorders. The institute was founded in 2000 by Patrick McGovern ...

. Wang is known for her work identifying neural circuits underlying

touch In physiology, the somatosensory system is the network of neural structures in the brain and body that produce the perception of touch (haptic perception), as well as temperature (thermoception), body position (proprioception), and pain. It is ...

pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ...

, and

anesthesia Anesthesia is a state of controlled, temporary loss of sensation or awareness that is induced for medical or veterinary purposes. It may include some or all of analgesia (relief from or prevention of pain), paralysis (muscle relaxation), ...

; and the development of a technique for capturing activated neuronal ensembles (CANE) to label and manipulate neurons activated by stimuli or behavioral paradigms.

Education and career

Wang received her PhD in 1998 from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

. Her thesis, titled ''Molecular genetic analysis of the olfactory sensory projections'', was advised by

Richard Axel Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won hi ...

. She did postdoctoral research with

Marc Tessier-Lavigne Marc Trevor Tessier-Lavigne (born December 18, 1959) is a Canadian-American neuroscientist who is the 11th and current president of Stanford University. Previously, he was a professor at the University of California, San Francisco and then pre ...

Stanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...

before joining the faculty at

Duke University School of Medicine The Duke University School of Medicine, commonly known as Duke Med, is the medical school of Duke University. It is located in the Collegiate Gothic-style West Campus of Duke University in Durham, North Carolina. The School of Medicine, along wit ...

in 2003 with appointments in neurobiology and cell biology. She was promoted to associate professor in 2013 and full professor in 2017. Wang was named Morris N. Broad Distinguished Professor of Neurobiology in 2018. In 2021, Wang joined the faculty at

MIT The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of the mo ...

as a professor in the

department of brain and cognitive sciences The Department of Brain and Cognitive Sciences at the Massachusetts Institute of Technology, Cambridge, Massachusetts, United States, engages in fundamental research in the areas of brain and neural systems, and cognitive processes. The department ...

and investigator at the

, maintaining an affiliation with the Duke Regeneration Center and adjunct professorship in neurobiology at Duke.

Research

The Wang lab uses molecular, genetic, and electrophysiological methods to understand how neural circuits enable or suppress touch, pain, and other senses or behaviors. Towards the creation of new tools for neuroscience, the Wang lab developed a technique for ''C''apturing ''A''ctivated ''N''euronal ''E''nsembles (CANE) by engineering mice to transiently co-express the TVA receptor when the

immediate early gene Immediate early genes (IEGs) are genes which are activated transiently and rapidly in response to a wide variety of cellular stimuli. They represent a standing response mechanism that is activated at the transcription level in the first round of ...

c-Fos Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the ''FOS'' gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkin ...

'' is expressed in response to neuronal activity, thereby enabling EnvA- pseudotyped viruses to specifically infect activated cells and drive stable expression of a desired transgene. This technique has been used to identify circuits involved in social vocalization, affective pain, sleep, anesthesia, and social fear. Using CANE, the Wang lab has identified anesthesia-activated neurons (AANs) whose activity promotes slow-wave sleep and extends general anesthesia. Wang has continued to investigate the

neural correlates of consciousness The neural correlates of consciousness (NCC) refer to the relationships between mental states and neural states and constitute the minimal set of neuronal events and mechanisms sufficient for a specific conscious percept. Neuroscientists use empi ...

in collaboration with

Kafui Dzirasa Kafui Dzirasa (born 1978) is an American psychiatrist and Associate Professor at Duke University. He looks to understand the relationship between neural circuit malfunction and mental illness. He was a 2019 AAAS Leshner Fellow and was elected ...

. In 2020, the Wang lab identified a key ensemble of mouse

GABAergic In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter GABA. For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A ...

neurons in the

central nucleus of the amygdala The central nucleus of the amygdala (CeA or aCeN) is a nucleus within the amygdala. It "serves as the major output nucleus of the amygdala and participates in receiving and processing pain information." CeA "connects with brainstem areas that con ...

(CeA_GA) that are activated by the

general anesthesia General anaesthesia (UK) or general anesthesia (US) is a medically induced loss of consciousness that renders the patient unarousable even with painful stimuli. This effect is achieved by administering either intravenous or inhalational general ...

drugs

isoflurane Isoflurane, sold under the brand name Forane among others, is a general anesthetic. It can be used to start or maintain anesthesia; however, other medications are often used to start anesthesia rather than isoflurane, due to airway irritation w ...

and

ketamine Ketamine is a dissociative anesthetic used medically for induction and maintenance of anesthesia. It is also used as a recreational drug. It is one of the safest anesthetics, as, in contrast with opiates, ether, and propofol, it suppresses ne ...

Optogenetic Optogenetics is a biological technique to control the activity of neurons or other cell types with light. This is achieved by expression of light-sensitive ion channels, pumps or enzymes specifically in the target cells. On the level of individ ...

activation of these neurons suppressed pain-elicited behaviors, whereas inhibition enhanced aversion and blocked the

analgesic An analgesic drug, also called simply an analgesic (American English), analgaesic (British English), pain reliever, or painkiller, is any member of the group of drugs used to achieve relief from pain (that is, analgesia or pain management). It ...

effect of ketamine. CeA_GA neurons directly project to many brain regions associated with

affective Affect, in psychology, refers to the underlying experience of feeling, emotion or mood. History The modern conception of affect developed in the 19th century with Wilhelm Wundt. The word comes from the German ''Gefühl'', meaning "feeling." ...

pain processing such as the

prefrontal cortex In mammalian brain anatomy, the prefrontal cortex (PFC) covers the front part of the frontal lobe of the cerebral cortex. The PFC contains the Brodmann areas BA8, BA9, BA10, BA11, BA12, BA13, BA14, BA24, BA25, BA32, BA44, BA45, BA46, ...

(pre-limbic and cingulate),

nucleus accumbens The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the ''nucleus accumbens septi'', Latin for "nucleus adjacent to the septum") is a region in the basal forebrain rostral to the preoptic area of the hypotha ...

, dorsal medial

striatum The striatum, or corpus striatum (also called the striate nucleus), is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain. The striatum is a critical component of the motor and reward systems; receives glutamate ...

insular cortex The insular cortex (also insula and insular lobe) is a portion of the cerebral cortex folded deep within the lateral sulcus (the fissure separating the temporal lobe from the parietal and frontal lobes) within each hemisphere of the mammalian bra ...

, bed nucleus of stria terminalis,

basolateral amygdala The basolateral amygdala, or basolateral complex, consists of the lateral, basal and accessory-basal nuclei of the amygdala. The lateral nuclei receives the majority of sensory information, which arrives directly from the temporal lobe structures, ...

subthalamus The subthalamus or prethalamus is a part of the diencephalon. Its most prominent structure is the subthalamic nucleus. The subthalamus connects to the globus pallidus, a basal nucleus of the telencephalon. Structure The subthalamus is locate ...

and perithalamus,

thalamic reticular nucleus The thalamic reticular nucleus is part of the ventral thalamus that forms a capsule around the thalamus laterally. However, recent evidence from mice and fish question this statement and define it as a dorsal thalamic structure. It is separated fro ...

intralaminar nuclei of thalamus The intralaminar thalamic nuclei (ITN) are collections of neurons in the internal medullary lamina of the thalamus that are generally divided in two groups as follows:Mancall, E., Brock, D. & Gray, H. (2011). Gray's clinical neuroanatomy the anatom ...

parabrachial nuclei The parabrachial nuclei, also known as the parabrachial complex, are a group of nuclei in the dorsolateral pons that surrounds the superior cerebellar peduncle as it enters the brainstem from the cerebellum. They are named from the Latin term for ...

, and

periaqueductal gray The periaqueductal gray (PAG, also known as the central gray) is a brain region that plays a critical role in autonomic function, motivated behavior and behavioural responses to threatening stimuli. PAG is also the primary control center for d ...

. These findings in mice may lay the foundation for future pain therapeutics in humans. The Wang lab also studies how neuronal circuits contribute to the complex phenomenon of

addiction Addiction is a neuropsychological disorder characterized by a persistent and intense urge to engage in certain behaviors, one of which is the usage of a drug, despite substantial harm and other negative consequences. Repetitive drug use o ...

, in which the drug-craving brain state may be analogous to that underlying affective pain. Her lab has mapped circuits that are activated or inhibited by

morphine Morphine is a strong opiate that is found naturally in opium, a dark brown resin in poppies (''Papaver somniferum''). It is mainly used as a analgesic, pain medication, and is also commonly used recreational drug, recreationally, or to make ...

and is testing whether reactivating inhibited neurons can reduce drug-seeking behavior.

Awards and honors

* 2020 Elected Member,

American Academy of Arts & Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States of America, United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bow ...

* 2016 Scientific Innovations Award, Brain Research Foundation * 2016 Keck Foundation Award, in collaboration with

* 2014 Elected Fellow, Section on Neuroscience,

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

* 2013

National Institutes of Health Director's Pioneer Award National Institutes of Health Director's Pioneer Award is a research initiative first announced in 2004 designed to support individual scientists' biomedical research. The focus is specifically on "pioneering" research that is highly innovative ...

* 2004

Sloan Research Fellowship The Sloan Research Fellowships are awarded annually by the Alfred P. Sloan Foundation since 1955 to "provide support and recognition to early-career scientists and scholars". This program is one of the oldest of its kind in the United States. ...

Alfred P. Sloan Foundation The Alfred P. Sloan Foundation is an American philanthropic nonprofit organization. It was established in 1934 by Alfred P. Sloan Jr., then-president and chief executive officer of General Motors. The Sloan Foundation makes grants to support or ...

References

{{Authority control Living people Columbia University alumni Chinese women neuroscientists Massachusetts Institute of Technology School of Science faculty Year of birth missing (living people)