FL3 is a synthetic

flavagline Flavaglines are a family of natural products that are found in plants of the genus ''Aglaia'' (Meliaceae). These compounds are characterized by a cyclopenta 'b''enzofuran skeleton. In 1982 King and colleagues discovered the first member of this ...

that displays potent anticancer and cardioprotectant activities. This compound induces the death of cancer cells by an original mechanism that involves the

apoptosis-inducing factor Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein. It al ...

and

caspase 12 Caspase 12 is a protein that in humans is encoded by the ''CASP12'' gene. The protein belongs to a family of enzymes called caspases which cleave their Substrate (biochemistry), substrates at C-terminal aspartic acid residues. It is closely rela ...

, suggesting that it may improve the efficacy of cancer chemotherapies. It was also shown that FL3 may enhance the efficacy of one of the most widely used anticancer agents, doxorubicin, and alleviate its main adverse effect, cardiac damage.

References

Diols Benzofuran ethers at the benzene ring Organobromides {{organic-compound-stub