The endocardial tubes are paired regions in the

embryo An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male spe ...

that appear in its ventral pole by the middle of the third week of gestation and consist of precursor cells for the development of the

embryonic heart Heart development, also known as cardiogenesis, refers to the prenatal development of the heart. This begins with the formation of two endocardial tubes which merge to form the tubular heart, also called the primitive heart tube. The heart is t ...

. The endocardial heart tubes derive from the visceral mesoderm and initially are formed by a confluence of

angioblast Angioblasts (or vasoformative cells) are embryonic cells from which the endothelium of blood vessels arises. They are derived from embryonic mesoderm. Blood vessels first make their appearance in several scattered vascular areas that are develope ...

ic blood vessels on either side of the embryonic midline. The endocardial tubes have an intimate proximity to the foregut or pharyngeal

endoderm Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gast ...

. As folding of the embryo in the horizontal plane initiates in the 4th week of gestation, the endocardial tubes meet in the midline to form the

primitive heart tube The tubular heart or primitive heart tube is the earliest stage of heart development. From the inflow to the outflow, it consists of sinus venosus, primitive atrium, the primitive ventricle, the bulbus cordis, and truncus arteriosus. It forms pri ...

, which will eventually develop into the histologically definitive

endocardium The endocardium is the innermost layer of tissue that lines the chambers of the heart. Its cells are embryologically and biologically similar to the endothelial cells that line blood vessels. The endocardium also provides protection to the va ...

. The

myocardium Cardiac muscle (also called heart muscle, myocardium, cardiomyocytes and cardiac myocytes) is one of three types of vertebrate muscle tissues, with the other two being skeletal muscle and smooth muscle. It is an involuntary, striated muscle that ...

forms from mesoderm cells surrounding the heart tube, while the

epicardium The pericardium, also called pericardial sac, is a double-walled sac containing the heart and the roots of the great vessels. It has two layers, an outer layer made of strong connective tissue (fibrous pericardium), and an inner layer made of ...

develops from other cells, most likely from

neural crest Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, per ...

cells.

References

External links

* * {{Development of circulatory system Embryology of cardiovascular system