Ethyl formate is an

ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides a ...

formed when

ethanol Ethanol (abbr. EtOH; also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound. It is an alcohol with the chemical formula . Its formula can be also written as or (an ethyl group linked to a ...

(an alcohol) reacts with formic acid (a carboxylic acid). Ethyl formate has the characteristic smell of

rum Rum is a liquor made by fermenting and then distilling sugarcane molasses or sugarcane juice. The distillate, a clear liquid, is usually aged in oak barrels. Rum is produced in nearly every sugar-producing region of the world, such as the Ph ...

and is also partially responsible for the flavor of

raspberries The raspberry is the edible fruit of a multitude of plant species in the genus ''Rubus'' of the rose family, most of which are in the subgenus '' Idaeobatus''. The name also applies to these plants themselves. Raspberries are perennial with ...

. It occurs naturally in the body of ants and in the stingers of bees.

Exposure

Ethyl formate is generally recognized as safe by the

U.S. Food and Drug Administration The United States Food and Drug Administration (FDA or US FDA) is a federal agency of the Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food ...

. According to the U.S Occupational Safety and Health Administration (OSHA), ethyl formate can irritate eyes, skin,

mucous membrane A mucous membrane or mucosa is a membrane that lines various cavities in the body of an organism and covers the surface of internal organs. It consists of one or more layers of epithelial cells overlying a layer of loose connective tissue. It i ...

s, and the

respiratory system The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants. The anatomy and physiology that make this happen varies ...

of humans and other animals; it is also a

central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...

depressant A depressant, or central depressant, is a drug that lowers neurotransmission levels, which is to depress or reduce arousal or stimulation, in various areas of the brain. Depressants are also colloquially referred to as downers as they lower the ...

. In industry, it is used as a solvent for

cellulose nitrate Nitrocellulose (also known as cellulose nitrate, flash paper, flash cotton, guncotton, pyroxylin and flash string, depending on form) is a highly flammable compound formed by nitrating cellulose through exposure to a mixture of nitric acid an ...

cellulose acetate In biochemistry, cellulose acetate refers to any acetate ester of cellulose, usually cellulose diacetate. It was first prepared in 1865. A bioplastic, cellulose acetate is used as a film base in photography, as a component in some coatings, and ...

, oils, and greases. It can be used as a substitute for

acetone Acetone (2-propanone or dimethyl ketone), is an organic compound with the formula . It is the simplest and smallest ketone (). It is a colorless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscib ...

; workers may also be exposed to it under the following circumstances: * during spray, brush, or dip applications of lacquers * during the manufacture of

safety glass Safety glass is glass with additional safety features that make it less likely to break, or less likely to pose a threat when broken. Common designs include toughened glass (also known as tempered glass), laminated glass, and wire mesh glass ...

* when fumigating tobacco, cereals, and

dried fruit Dried fruit is fruit from which the majority of the original water content has been removed either naturally, through sun drying, or through the use of specialized dryers or dehydrators. Dried fruit has a long tradition of use dating back to th ...

s (as an alternative to methyl bromide under the

U.S. Department of Agriculture The United States Department of Agriculture (USDA) is the federal executive department responsible for developing and executing federal laws related to farming, forestry, rural economic development, and food. It aims to meet the needs of comme ...

quarantine system) OSHA considers a time-weighted average of 100

parts per million In science and engineering, the parts-per notation is a set of pseudo-units to describe small values of miscellaneous dimensionless quantities, e.g. mole fraction or mass fraction. Since these fractions are quantity-per-quantity measures, th ...

(300 milligrams per cubic meter) over an eight-hour period as the

permissible exposure limit The permissible exposure limit (PEL or OSHA PEL) is a legal limit in the United States for exposure of an employee to a chemical substance or physical agent such as high level noise. Permissible exposure limits are established by the Occupational ...

. The

U.S. National Institute for Occupational Safety and Health The National Institute for Occupational Safety and Health (NIOSH, ) is the United States federal agency responsible for conducting research and making recommendations for the prevention of work-related injury and illness. NIOSH is part of the ...

(NIOSH) also considers a time-weighted average of 100 ppm over an eight-hour period as the

recommended exposure limit A recommended exposure limit (REL) is an occupational exposure limit that has been recommended by the United States National Institute for Occupational Safety and Health. The REL is a level that NIOSH believes would be protective of worker safet ...

.CDC - NIOSH Pocket Guide to Chemical Hazards
.

In space

Ethyl formate has been identified in dust clouds in an area of the Milky Way galaxy called

Sagittarius B2 Sagittarius B2 (Sgr B2) is a giant molecular cloud of gas and dust that is located about from the center of the Milky Way. This complex is the largest molecular cloud in the vicinity of the core and one of the largest in the galaxy, spanning a r ...

. It is among 50 molecular species identified using the 30 metre IRAM radiotelescope.

References

{{Molecules detected in outer space Ethyl esters Formate esters