This is a list of

estrogen ester An estrogen ester is an ester of an estrogen, most typically of estradiol but also of other estrogens such as estrone, estriol, and even nonsteroidal estrogens like diethylstilbestrol. Esterification renders estradiol into a prodrug of estradio ...

s, or

ester In chemistry, an ester is a compound derived from an oxoacid (organic or inorganic) in which at least one hydroxyl group () is replaced by an alkoxy group (), as in the substitution reaction of a carboxylic acid and an alcohol. Glycerides a ...

prodrugs of

estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal ac ...

s. It includes esters, as well as

ether In organic chemistry, ethers are a class of compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups. They have the general formula , where R and R′ represent the alkyl or aryl groups. Ethers can again be ...

s, of steroidal

s like

estradiol Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development o ...

estrone Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized ...

, and

estriol Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estrone. Levels of estriol in women who are not pregnant are almost ...

and of

nonsteroidal estrogen A nonsteroidal estrogen is an estrogen with a nonsteroidal chemical structure. The most well-known example is the stilbestrol estrogen diethylstilbestrol (DES). Although nonsteroidal estrogens formerly had an important place in medicine, they ha ...

s like the

stilbestrol Stilbestrol, or stilboestrol, also known as 4,4'-dihydroxystilbene or 4,4'-stilbenediol, is a stilbenoid nonsteroidal estrogen and the parent compound of a group of more potent nonsteroidal estrogen derivatives that includes, most notably, dieth ...

diethylstilbestrol Diethylstilbestrol (DES), also known as stilbestrol or stilboestrol, is a nonsteroidal estrogen medication, which is presently rarely used. In the past, it was widely used for a variety of indications, including pregnancy support for those with a ...

and

hexestrol Hexestrol, sold under the brand name Synestrol among others, is a nonsteroidal estrogen which was previously used for estrogen replacement therapy and in the treatment of certain hormone-dependent cancers as well as gynecological disorders but ...

Esters of steroidal estrogens

Estradiol esters

Marketed

Many esters of estradiol have been marketed, including the following major esters: *

Estradiol acetate Estradiol acetate (EA), sold under the brand names Femtrace, Femring, and Menoring, is an estrogen medication which is used in hormone therapy for the treatment of menopausal symptoms in women.https://www.accessdata.fda.gov/drugsatfda_docs/labe ...

(Femring, Femtrace, Menoring) *

Estradiol benzoate Estradiol benzoate (EB), sold under the brand name Progynon-B among others, is an estrogen medication which is used in hormone therapy for menopausal symptoms and low estrogen levels in women, in hormone therapy for transgender women, and in t ...

(Agofollin Depot, Progynon-B; Duogynon, Primosiston, Sistocyclin) *

Estradiol cypionate Estradiol cypionate (EC), sold under the brand name Depo-Estradiol among others, is an estrogen medication which is used in hormone therapy for menopausal symptoms and low estrogen levels in cis women, in hormone therapy for trans women, and in ...

(Depo-Estradiol, Depofemin, Estradep; Cyclofem, Lunelle) *

Estradiol dipropionate Estradiol dipropionate (EDP), sold under the brand names Agofollin, Di-Ovocylin, and Progynon DP among others, is an estrogen medication which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the ...

(Agofollin, Di-Ovocyclin, Progynon-DP; EP Hormone Depot) * Estradiol enantate (Perlutal, Topasel, Unalmes, Yectames) *

Estradiol undecylate Estradiol undecylate (EU or E2U), also known as estradiol undecanoate and formerly sold under the brand names Delestrec and Progynon Depot 100 among others, is an estrogen medication which has been used in the treatment of prostate cancer in men. ...

(Delestrec, Progynon Depot) *

Estradiol valerate Estradiol valerate (EV), sold for use by mouth under the brand name Progynova and Primiwal E4 and for use by injection under the brand names Delestrogen and Progynon Depot among others, is an estrogen medication. It is used in hormone therapy fo ...

(Delestrogen, Progynon Depot, Progynova; Gravibinon, Mesigyna, Mesygest) *

Polyestradiol phosphate Polyestradiol phosphate (PEP), sold under the brand name Estradurin, is an estrogen medication which is used primarily in the treatment of prostate cancer in men. It is also used in women to treat breast cancer, as a component of hormone thera ...

(Estradurin) (an estradiol ester in

polymer A polymer (; Greek '' poly-'', "many" + ''-mer'', "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic a ...

ic form) And the following less commonly used esters: * Cloxestradiol acetate (Genovul; diacetate ester of cloxestradiol, or estradiol 17β-chloral hemiacetal ether) * Estradiol benzoate butyrate (Redimen, Soluna, Unijab, Unimens) * Estradiol butyrylacetate (Follikoside) * Estradiol dibutyrate (Triormon Depositum) * Estradiol dienantate (Climacteron, Lactimex, Lactostat) *

Estradiol diundecylate Estradiol diundecylate (brand name Estrolent), or estradiol diundecanoate, also known as 17β-estradiol 3,17β-diundecylate, is an estrogen and an estrogen ester – specifically, the 3,17β-di undecylate ester of estradiol – which has been m ...

(Estrolent; Trioestrine Retard) *

Estradiol diundecylenate Estradiol diundecylenate (brand name Etrosteron), or estradiol diundecenoate, also known as 17β-estradiol 3,17β-diundec-10-enoate, is a semisynthetic steroidal estrogen and an estrogen ester – specifically, the 3,17β-di undecylenate ester ...

(Etrosteron) *

Estradiol furoate Estradiol furoate (EF), or estradiol 17β-furoate, sold under the brand name Di-Folliculine, is an estrogen medication and estrogen ester which is no longer marketed. It is the C17β furoate ester of estradiol. Estradiol benzoate has also be ...

(Di-Folliculine) * Estradiol hemisuccinate (Eutocol; Hosterona) *

Estradiol hexahydrobenzoate Estradiol hexahydrobenzoate (EHHB), sold under a number of brand names including Benzo-Ginoestril A.P., BenzoGynoestryl Retard, Ginestryl-15-Depot, Menodin, and Tardoginestryl, is an estrogen medication which was previously used for indications ...

(Benzo-Ginoestril A.P., BenzoGynoestryl Retard, Ginestryl-15-Depot, Menodin, Tardoginestryl) *

Estradiol palmitate Estradiol palmitate (brand name Esmopal), or estradiol monopalmitate, also known as estradiol 17β-hexadecanoate, is a naturally occurring steroidal estrogen and an estrogen ester – specifically, the C17β palmitate ester of estradiol. It occu ...

(Esmopal) *

Estradiol phenylpropionate Estradiol phenylpropionate (EPP), also known as estradiol 17β-phenylpropionate and sold under the brand name Menformon Prolongatum, is an estrogen which is no longer marketed. It is an estrogen ester, specifically the C17β phenylpropionate est ...

(Dimenformon Prolongatum; Estandron Prolongatum, Lynandron Prolongatum, Mixogen) *

Estradiol pivalate Estradiol pivalate, also known as estradiol trimethyl acetate (E2-TMA) and sold under the brand name Estrotate, is an estrogen medication and an estrogen ester; specifically, a pivalic acid (trimethylacetic acid) ester of estradiol. Literature so ...

(Estrotate; Estrotate with Progesterone) * Estradiol propionate (estradiol 17β-propionate) (Acrofollin, Akrofollin, Follhormon) * Estradiol propoxyphenylpropionate (Durovex) *

Estradiol stearate Estradiol stearate (E2-17-St), also known as estradiol octadecanoate and sold under the brand name Depofollan, is a naturally occurring estrogen and an estrogen ester – specifically, the C17β stearate ester of estradiol. It occurs in the body ...

(Depofollan) *

Estradiol sulfate Estradiol sulfate (E2S), or 17β-estradiol 3-sulfate, is a natural, endogenous steroid and an estrogen ester. E2S itself is biologically inactive, but it can be converted by steroid sulfatase (also called estrogen sulfatase) into estradiol, whi ...

(a minor constituent of

conjugated estrogens Conjugated estrogens (CEs), or conjugated equine estrogens (CEEs), sold under the brand name Premarin among others, is an estrogen medication which is used in menopausal hormone therapy and for various other indications. It is a mixture of the ...

(Premarin)) The following nitrogen mustard ester of estradiol is a cytostatic antineoplastic agent and has been marketed: * Estramustine phosphate (Emcyt, Estracyt; estradiol 3-normustine 17β-phosphate)

Never marketed

A number of other estradiol esters which have not been marketed include: *

Estradiol 3-furoate Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of ...

Estradiol 3-propionate Estradiol 3-propionate, or 3-propanoylestradiol, also known as estra-1,3,5(10)-triene-3,17β-diol 3-propionate, is a semisynthetic, steroidal estrogen that was never marketed. It is an estrogen ester, specifically, a propionic acid ester of es ...

(''not to be confused with estradiol monopropionate (estradiol 17β-propionate)'') * Estradiol 17β-(1-(4-(aminosulfonyl)benzoyl)--proline) (EC508)Nickisch, K., Santhamma, B., Ahmed, G., Meece, F., Elger, W., Wyrwa, R., & Nair, H. (2017). ''U.S. Patent No. 9,745,338.'' Washington, DC: U.S. Patent and Trademark Office. https://patents.google.com/patent/US9745338B2/en * Estradiol acetate benzoate * Estradiol 17β-acetate * Estradiol 17β-benzoate *

Estradiol acetylsalicylate Estradiol acetylsalicylate, or estradiol 3-acetylsalicylate, is a synthetic estrogen and estrogen ester – specifically, the C3 acetylsalicylic acid (aspirin) ester of estradiol – which was described in the late 1980s and was never marketed. I ...

(estradiol 3-acetylsalicylate) *

Estradiol anthranilate Estradiol anthranilate, or estradiol 3-anthranilate, is a synthetic estrogen and estrogen ester – specifically, the C3 anthranilic acid ester of estradiol – which was described in the late 1980s and was never marketed. In dogs, the oral bioav ...

(estradiol 3-anthranilate) * Estradiol arachidonate * Estradiol benzoate cyclooctenyl ether (estradiol 3-benzoate 17β-cyclooctenyl ether; EBCO) *

Estradiol caprylate Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of ...

(estradiol octanoate) *

Estradiol cyclooctyl acetate Estradiol cyclooctyl acetate (E2COA), or estradiol 17β-cyclooctylacetate, also known as estra-1,3,5(10)-triene-3,17β-diol 17β-cyclooctylacetate, is an estrogen medication and an estrogen ester – specifically, the 17β- cyclooctylacetate este ...

(E2CoA) * Estradiol decanoate (estradiol 17β-decanoate) * Estradiol diacetate *

Estradiol dibenzoate Estradiol dibenzoate (EDB), also known as estradiol 3,17β-dibenzoate, is an estrogen ester which was developed in the 1930s and was never marketed. It is the C3 and C17β benzoate diester of estradiol. Estradiol dibenzoate has a longer duration ...

* Estradiol dicypionate *

Estradiol dioleate Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous cycle, estrous and menstrual cycle, menstrual female reproductive cycles. Estradiol is resp ...

* Estradiol dipalmitate *

Estradiol distearate Estradiol distearate (EDS), also known as estradiol dioctadecanoate, is an estrogen and an estrogen ester which was never marketed. It is a long-acting prodrug of estradiol in the body. See also * Estradiol dienantate Estradiol dienantha ...

Estradiol disulfate Estradiol disulfate (also known as E2DS or estradiol 3,17β-disulfate) is an endogenous estrogen conjugate and metabolite of estradiol. It is related to estradiol 3-sulfate and estradiol 17β-sulfate. Estradiol disulfate has 0.0004% of the r ...

Estradiol glucuronide Estradiol glucuronide, or estradiol 17β-D-glucuronide, is a conjugated metabolite of estradiol. It is formed from estradiol in the liver by UDP-glucuronyltransferase via attachment of glucuronic acid and is eventually excreted in the urine ...

* Estradiol sulfate glucuronide *

Estradiol linoleate Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of ...

Estradiol oleate Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous cycle, estrous and menstrual cycle, menstrual female reproductive cycles. Estradiol is resp ...

Estradiol phosphate Estradiol phosphate, or estradiol 17β-phosphate, also known as estra-1,3,5(10)-triene-3,17β-diol 17β-(dihydrogen phosphate), is an estrogen which was never marketed. It is an estrogen ester, specifically an ester of estradiol with phosphoric ...

Estradiol salicylate Estradiol salicylate, or estradiol 3-salicylate, is a synthetic estrogen and estrogen ester – specifically, the C3 salicylic acid ester of estradiol – which was described in the late 1980s and was never marketed. It is a metabolite of estrad ...

(estradiol 3-salicylate) *

Estradiol sulfamate Estradiol sulfamate (E2MATE; developmental code names J995, PGL-2, PGL-2001, ZK-190628, others), or estradiol-3-''O''-sulfamate, is a steroid sulfatase (STS) inhibitor which is under development for the treatment of endometriosis. It is the C3 su ...

(E2MATE; J995, PGL-2, PGL-2001, ZK-190628; estradiol-3-O-sulfamate) *

Estradiol undecylenate Estradiol undecylenate (EUe; developmental code name SH-368) is an estrogen medication and estrogen ester which was never marketed. It is the C17β undecenoate (undecylenate) ester of estradiol. Following an intramuscular injection, EUe has a v ...

(SH-368) *

Estrapronicate Estrapronicate (), also known as estradiol nicotinate propionate is an estrogen medication and estrogen ester which was never marketed. It was studied as a component of the experimental tristeroid combination drug Trophobolene, which contained n ...

(estradiol 3-propionate 17β-nicotinate; Trophobolene, Trophoboline) *

Orestrate Orestrate (), also known as estradiol 3-propionate 17β-(1-cyclohexenyl) ether, is an estrogen medication and estrogen ester which was never marketed. It is the C3 propionate ester and C17β-(1- cyclohexenyl) ether of estradiol Estradiol (E2) ...

(estradiol 3-propionate 17β-(1-cyclohexenyl) ether) The following cytostatic antineoplastic nitrogen mustard esters of estradiol have not been marketed: *

Alestramustine Alestramustine (), also known as estradiol 3-(''bis''(2-chloroethyl)carbamate) 17β-(L-alaninate), is a cytostatic antineoplastic agent which was never marketed. It is the L-alanine ester of estramustine, which is a combination of the nitrogen ...

(estradiol 3-(bis(2-chloroethyl)carbamate), 17-ester with L-alanine) *

Atrimustine Atrimustine () (developmental code name KM-2210; former tentative brand name Kregan), also known as bestrabucil or busramustine, is a cytostatic antineoplastic agent which was under development in Japan by Kureha Chemicals (now Kureha Corporati ...

(KM-2210; bestrabucil, busramustine) * Estradiol mustard (NSC-112259; chlorphenacyl estradiol diester) *

Estramustine Estramustine (, , ) is an estrogen and cytostatic antineoplastic agent which was never marketed. It is an estrogen ester – specifically, the C3 normustine ester of estradiol – and acts in part as a prodrug of estradiol in the body. Estramus ...

(Leo 275; Ro 21-8837) *

Estromustine Estromustine (developmental code name Leo 271 f), also known as estrone 17β-3-N-bis(2-chloroethyl)carbamate or estrone–cytostatic complex, is a major active metabolite of the cytostatic antineoplastic agent and estrogen estramustine phospha ...

(Leo 271 f; estrone 17β-3-N-bis(2-chloroethyl)carbamate, estrone–cytostatic complex)

Estrone esters

Marketed

Esters of estrone that have been marketed include: * Estrone acetate (Hovigal) *

Estrone sulfate Estrone sulfate, also known as E1S, E1SO4 and estrone 3-sulfate, is a natural, endogenous steroid and an estrogen ester and conjugate. In addition to its role as a natural hormone, estrone sulfate is used as a medication, for instance in menop ...

(as the primary component of

(Premarin)) **

Estropipate Estropipate, also known as piperazine estrone sulfate and sold under the brand names Harmogen, Improvera, Ogen, Ortho-Est, and Sulestrex among others, is an estrogen medication which is used mainly in menopausal hormone therapy in the treatmen ...

(Ogen, Ortho-Est) (a salt of estrone sulfate and

piperazine Piperazine () is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste. The piperazines are a broad ...

) * Estrone tetraacetylglucoside (Glucovex, Glycovex)

Never marketed

Other estrone esters which are notable but have not been marketed include: * Estrone benzoate *

Estrone cyanate Estrone cyanate, or estrone 3-''O''-cyanate, also known as estrocyanate, is an estrogen and an estrogen ester – specifically, the 3-O-cyanate ester of estrone – which was investigated for potential use in birth control pills but was found to ...

Estrone enanthate Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are biosynthesis, ...

Estrone enanthate benzilic acid hydrazone Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized ...

Estrone glucuronide Estrone glucuronide, or estrone-3-D-glucuronide, is a conjugated metabolite of estrone. It is formed from estrone in the liver by UDP-glucuronyltransferase via attachment of glucuronic acid and is eventually excreted in the urine by the kidn ...

Estrone phosphate Estrone phosphate (E1P), or estrone 3-phosphate, is an estrogen and steroid sulfatase inhibitor which was never marketed. It has similar affinity for steroid sulfatase as estrone sulfate and acts as a competitive inhibitor of the enzyme. In contr ...

Estrone propionate Estrone (E1), also spelled oestrone, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major endogenous estrogens, the others being estradiol and estriol. Estrone, as well as the other estrogens, are synthesized ...

Estrone sulfamate Estrone sulfamate (EMATE; developmental code name J994), or estrone-3-''O''-sulfamate, is a steroid sulfatase (STS) inhibitor which has not yet been marketed. It is the C3 sulfamate ester of the estrogen estrone. Unlike other estrogen esters howe ...

(EMATE; J994; estrone-3-O-sulfamate) *

Estrone oleate Oleoyl-estrone (OE), or estrone 3-oleate, is a fatty acid ester of estrone. It is a naturally circulating hormone in animals, including humans. It was studied as a potential weight-loss drug, but failed to show benefit in clinical trials. It was ...

Estriol esters

Marketed

Esters of estriol that have been marketed include: *

Estriol 3-glucuronide Estriol 3-glucuronide, or oestriol 3-glucuronide, also known as estriol 3-β-D-glucosiduronic acid, is a natural, steroidal estrogen and a glucuronic acid (β-D-glucopyranuronic acid) conjugate of estriol. It is found in the urine of women as a ...

(as a component of

conjugated estriol Conjugated estriol, sold under the brand names Progynon and Emmenin, is an estrogen (medication), estrogen medication which was previously used for estrogen-type indications such as the treatment of menopausal symptoms in women. The term specifi ...

(Emmenin, Progynon)) *

Estriol acetate benzoate Estriol acetate benzoate () (brand name Holin-Depot), or oestriol diacetate benzoate (), is an estrogen medication. It is an estrogen ester An estrogen ester is an ester of an estrogen, most typically of estradiol but also of other estrogens ...

(Holin-Depot) *

Estriol glucuronide Estriol glucuronide (E3G), or oestriol glucuronide, also known as estriol monoglucuronide, as well as estriol 16α-β-D-glucosiduronic acid, is a natural, steroidal estrogen and the glucuronic acid (β-D-glucopyranuronic acid) conjugate of estri ...

(as a component of

(Emmenin, Progynon)) * Estriol succinate (Sinapause, Styptanon, Synapause) ** Estriol sodium succinate (Pausan, Styptanon) *

Estriol sulfate Estriol sulfate, or estriol 3-sulfate, is a conjugated metabolite of estriol that is present in high quantities during pregnancy. It is formed from estriol in the liver and is eventually excreted in the urine by the kidneys. It has much higher ...

(as a component of

(Emmenin, Progynon)) *

Estriol sulfate glucuronide Estriol sulfate glucuronide, or estriol 3-sulfate 16α-glucuronide, is an endogenous, naturally occurring diconjugated metabolite of estriol. It is generated in the liver from estriol sulfate by UDP-glucuronyltransferase and is eventually excret ...

(as a component of

(Emmenin, Progynon)) *

Estriol tripropionate Estriol tripropionate (brand name Estriel), or estriol tripropanoate, is an estrogen medication. It is an estrogen ester, specifically, an ester of estriol Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female ...

(Estriel) * Polyestriol phosphate (Gynäsan, Klimadurin, Triodurin) (an estriol ester in

ic form)

Never marketed

The following ester of estriol was never marketed: * Estriol dihexanoate * Estriol dipropionate *

Estriol phosphate Estriol phosphate (E3P), or estriol 17β-phosphate, also known as estra-1,3,5(10)-triene-3,16α,17β-triol 17β-(dihydrogen phosphate), is an estrogen which was never marketed. It is an estrogen ester, specifically an ester of estriol with phosp ...

(E3P) * Estriol sulfamate (E3MATE; J1034; estriol-3-O-sulfamate) * Estriol triacetate

Ethinylestradiol esters

Marketed

The following esters of

ethinylestradiol Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disord ...

exist and have been marketed: *

Ethinylestradiol sulfonate Ethinylestradiol sulfonate (EES), sold under the brand names Deposiston and Turisteron among others, is an estrogen (medication), estrogen medication which has been used in birth control pills for women and in the treatment of prostate cancer in ...

(Turisteron; ethinylestradiol 3-isopropylsulfonate)

Never marketed

* Ethinylestradiol benzoate – the 3-benzoate ester of

* Ethinylestradiol ''N'',''N''-diethylsulfamate (J271) – the 3-(''N'',''N''-diethyl)sulfamate ester of

Ethinylestradiol pyrrolidinosulfonate Ethinylestradiol (EE) is an estrogen medication which is used widely in birth control pills in combination with progestins. In the past, EE was widely used for various indications such as the treatment of menopausal symptoms, gynecological disor ...

(J272) – the 3-pyrrolidinosulfonate ester of

Ethinylestradiol sulfamate Ethinylestradiol sulfamate (developmental code name J1028), or 17α-ethynylestradiol 3-''O''-sulfamate, is a synthetic compound, synthetic estrogen (medication), estrogen and estrogen ester which was never marketed.Schwarz, S., Elger, W., Sieman ...

(J1028) – the 3-sulfamate ester of

Ethinylestradiol sulfate Ethinylestradiol sulfate (EE sulfate), also known as 17α-ethynylestradiol 3-sulfate, is an estrogen ester – specifically, the C3 sulfuric acid (sulfate) ester of the synthetic compound, synthetic estrogen (medication), estrogen ethinylestradi ...

Esters of other steroidal estrogens

Marketed

The following esters of other estrogens exist and have been marketed: * Hydroxyestrone diacetate (Colpoginon, Colpormon, Hormobion, Hormocervix) – the 3,16α-diacetate ester of 16α-hydroxyestrone

Ethers of steroidal estrogens

Marketed

A number of estrogen ''

s'' also exist and have been marketed, including: *

Clomestrone Clomestrone (brand names Arterolo, Atheran, Colesterel, Iposclerone, Liprotene, Persclerol, others; former developmental code name SC-8246), also known as 16α-chloroestrone 3-methyl ether, is a synthetic, steroidal, weak estrogen derived from e ...

(Arterolo, Atheran, Colesterel, Iposclerone, Liprotene, Persclerol) – the 3-methyl ether of 16α-chloroestrone * Cloxestradiol acetate (Genovul) – the ''O'',''O''-diacetate ester of cloxestradiol (estradiol 17β-chloral hemiacetal ether) * Mestranol (Devocin, Ovastol, Tranel) (component of Enovid, Enavid, Ortho-Novin, Femigen, Norbiogest) – the 3-methyl ether of

Moxestrol Moxestrol, sold under the brand name Surestryl, is an estrogen medication which has been used in Europe for the treatment of menopausal symptoms and menstrual disorders. It is taken by mouth. In addition to its use as a medication, moxestrol has ...

(Surestryl) – the 11β-methoxy derivative of

(and hence the 11β-methyl ether of the 11β-hydroxyl derivative of ethinylestradiol) * Nilestriol (Wei Ni An) – the 3-cyclopentyl ether of ethinylestriol * Promestriene (Colpotrofin, Colpotrophine, Delipoderm) – the 3-propyl and 17β-methyl diether of

* Quinestradol (Colpovis, Colpovister, Pentovis) – the 3-cyclopentyl ether of

Quinestrol Quinestrol, also known as ethinylestradiol cyclopentyl ether (EECPE), sold under the brand name Estrovis among others, is an estrogen medication which has been used in menopausal hormone therapy, hormonal birth control, and to treat breast cancer ...

(Agalacto-Quilea, Basaquines, Eston, Estrovis, Estrovister, Plestrovis, Qui-lea) – the 3-cyclopentyl ether of

Never marketed

A few other estrogen ethers which are notable but have not been marketed include: * Cloxestradiol – the 17β-chloral hemiacetal ether of

* Estradiol benzoate cyclooctenyl ether – the 17β-cyclooctenyl ether of estradiol 3-benzoate * Estradiol 3-saccharinylmethyl ether – the 3-(saccharinylmethyl) ether of

* Estradiol 3-tetrahydropyranyl ether – the 3-(tetrahydropyran-2-yl) ether of

* Estradiol 17β-tetrahydropyranyl ether – the 17β-(tetrahydropyran-2-yl) ether of

* Estrone methyl ether – the 3-methyl ether of

Mytatrienediol Mytatrienediol (developmental code name SC-6924; former tentative brand names Manvene, Anvene), also known as 16α-methyl-16β-epiestriol 3-methyl ether or 16β-hydroxy-16α-methylestradiol 3-methyl ether, is a synthetic steroidal estrogen medica ...

– the 3-methyl ether of 16α-methyl-16β-epiestriol *

– the 17β-(1-cyclohexenyl) ether of

estradiol 3-propionate Estradiol 3-propionate, or 3-propanoylestradiol, also known as estra-1,3,5(10)-triene-3,17β-diol 3-propionate, is a semisynthetic, steroidal estrogen that was never marketed. It is an estrogen ester, specifically, a propionic acid ester of es ...

Esters of nonsteroidal estrogens

Diethylstilbestrol esters

Marketed

Major esters of diethylstilbestrol include: *

Diethylstilbestrol dipropionate Diethylstilbestrol dipropionate (DESDP) (brand names Agostilben, Biokeral, Clinestrol, Cyclen, Estilbin, Estril, Neobenzoestrol, Orestol, Oroestrol, Ostregenin, Prostilbene, Stilbestriol DP, Stilboestrolum Dipropionicum, Stilboestrol, Synestrin, W ...

(Agostilben, Biokeral, Clinestrol, Cyclen, Estilbin, Estril, Neobenzoestrol, Orestol, Oroestrol, Ostregenin, Prostilbene, Stilbestriol DP, Stilboestrolum Dipropionicum, Stilboestrol, Synestrin, Willestrol) *

Fosfestrol Fosfestrol, sold under the brand name Honvan and also known as diethylstilbestrol diphosphate (DESDP), is an estrogen medication which is used in the treatment of prostate cancer in men. It is given by slow intravenous infusion once per day to on ...

(diethylstilbestrol diphosphate) (Honvan, Difostilben, Fosfostilben, Fostrolin, Stilbol, Stilphostrol, Vagestrol) Less commonly used esters of diethylstilbestrol include: * Diethylstilbestrol diacetate (Hormostilboral Stark) * Diethylstilbestrol dilaurate (Acnestrol-Lotion) * Diethylstilbestrol dipalmitate (stilpalmitate) (Palmestril, Stilpalmitate) *

Diethylstilbestrol disulfate Diethylstilbestrol disulfate (brand names Hydroestryl, Idroestril; former developmental code name M.G. 137) is a synthetic, nonsteroidal estrogen of the stilbestrol group and an ester of diethylstilbestrol Diethylstilbestrol (DES), also known a ...

(Hydroestryl, Idroestril)

Never marketed

* Diethylstilbestrol sulfate * Furostilbestrol (diethylstilbestrol difuroate) *

Polydiethylstilbestrol phosphate Polydiethylstilbestrol phosphate (PSP, PDSP) is an estrogen (medication), estrogen medication which has been used in scientific research and has been studied for use in veterinary medicine as a livestock growth promoter. It is a phosphate ester of ...

As well as the following nitrogen mustard ester: *

ICI-85966 ICI-85966 (former tentative brand name Stilbostat), also known as diethylstilbestrol (DES) bis(di(2-chloroethyl)carbamate), is a synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent of the stilbestrol group and a nitrogen mustard e ...

(Stilbostat; diethylstilbestrol bis(di(2-chloroethyl)carbamate))

Hexestrol esters

Marketed

Hexestrol diacetate Hexestrol diacetate ( JAN) (brand names Retalon Lingual, Robal, Sintestrol, Sintofolin) is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. It is an ester of hexestrol, and was discovered in 1939. See ...

(Retalon Lingual, Robal, Sintestrol, Sintofolin) * Hexestrol dicaprylate (dioctanoylhexestrol) (Taston) * Hexestrol diphosphate (Cytostesin, Pharmestrin, Retalon Aquosum) *

Hexestrol dipropionate Hexestrol dipropionate (brand name Hexanoestrol, Retalon Oleosum), or hexestrol dipropanoate, is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. It is an ester of hexestrol, and has been known since at ...

(Hexanoestrol, Retalon Oleosum) *

Hexestrol phosphate Hexestrol diphosphate (brand names Cytostatin, Cytostesin, Pharmestrin, Retalon Aquosum) is a Organic compound#Synthetic compounds, synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol and used as an estrogen and ...

(Retalon Aquosum)

Never marketed

The following nitrogen mustard ester of hexestrol was never marketed: *

Phenestrol Phenestrol, or fenestrol, also known as hexestrol bis -[bis(2-chloroethyl)aminohenylacetate, is a synthetic compound">synthetic, nonsteroidal estrogen and cytostatic antineoplastic agent (i.e., chemotherapy drug) and a chlorine, chlorphenyl group, ...

(fenestrol; hexestrol bis[4-[bis(2-chloroethyl)amino]phenylacetate)

Esters of other nonsteroidal estrogens

Marketed

* Dienestrol diacetate (Faragynol, Gynocyrol) * Methestrol dipropionate (promethestrol dipropionate, dimethylhexestrol dipropionate) (Meprane Dipropionate)

Ethers of nonsteroidal estrogens

Diethylstilbestrol

Marketed

* Diethylstilbestrol monobenzyl ether (benzelstilbestrol) (Monozol, Hypantin, Pituitrope) *

Dimestrol Dimestrol (brand names Depot-Cyren, Depot-Oestromon), also known as dianisylhexene, 4,4'-dimethoxy-α,α'-diethylstilbene, diethylstilbestrol dimethyl ether, and dimethoxydiethylstilbestrol, is a synthetic nonsteroidal estrogen of the stilbestr ...

(dianisylhexene, diethylstilbestrol dimethyl ether, dimethoxydiethylstilbestrol) (Depot-Ostromon, Synthila) *

Mestilbol Mestilbol (brand name Monomestro or Monomestrol), also known as diethylstilbestrol monomethyl ether, is a synthetic nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol. It was developed by Wallace & Tiernan Company, pat ...

(diethylstilbestrol monomethyl ether) (Monomestro or Monomestrol)

References

{{Estrogen receptor modulators Estrogen esters Estrogens Prodrugs